Conan chats with miner Brad about mine design, Conan burying himself deep, and mining positions. They discuss efficient mining, depth challenges, and Conan's potential in the mining industry.

Comedian and actor Paul Scheer joins Conan O'Brien to discuss his new memoir, awkward celebrity encounters, and incorporating a celebrity impersonator into his wedding. They banter about owning a fake video store, childhood dreams, and hilarious celebrity confrontations. The episode is filled with humor and entertaining anecdotes.

Conan chats with Anthony, a phlebotomist who sings in a metal band, about blood extraction, unique biology, struggles with veins, and his role as a scream vocalist. They also discuss the challenges of microphone sensitivity, Monopoly Go enhancements, T-Mobile coverage, musical misinformation, and a Samsung TV channel dedicated to Conan.

Tiffany Haddish joins Conan O’Brien to chat about her new memoir, South Central LA investments, scandalous Face/Off association, and background work. They share funny anecdotes, including a debrief on McDonald's fries, NASA shenanigans, childhood misconceptions, and authenticity in comedy. The episode covers decluttering, rage rooms, community impact, and phone number exchanges.

Dr. Arroyo discusses unique patient encounters outside Mayo Clinic, benefits of Car Shield and T-Mobile network, financial strategies with Robinhood and LinkedIn networking, confidentiality in medical practice, and comical incidents with high-profile clients.

Conan talks to Brian Setzer about his rockabilly and big band music blend. They discuss the inspirations behind his songs, from Eddie Cochran to The Beatles. They delve into TV theme songs influencing music culture and reminisce about iconic tunes. Setzer reflects on his rebellious influences like Gene Vincent and Cliff Gallup, and shares anecdotes of encounters with music legends like Chad Atkins and Les Paul. The conversation also touches on financial investments and the challenges of traveling as a musician.

Comedian Taylor Tomlinson chats with Conan O’Brien about hosting a late-night show, reading off a teleprompter, advice from Stephen Colbert, and the workaholic nature of the entertainment field. Conan shares behind-the-scenes of his Hot Ones experience, while Sona and Matt hunt for their cars on the streets.

Conan chats with Margaret about intuitive music composition, childhood creativity, and a personalized musical motif. They discuss California adventures, Canva presentations, and the age-old debate of Ding Dongs vs. Ring Dings.

Comedian Jimmy Carr chats with Conan O'Brien about stand-up in the current era, crafting jokes on the road, and the origins of comedy according to Dunbar's number. They also discuss late-night rivalries, the evolution of podcasts, and navigating fame and social dynamics in the comedy world.

Conan O'Brien compiles fan interactions from his international fans, who ended up being part of his new travel show. Topics include funny conversations, dating preferences, listener numbers for a radio show, and a medical student's aspirations.