Healthcare Unfiltered

Chadi is joined by Drs. Rana McKay and Petros Grivas to discuss the latest genitourinary oncology research updates from the 2024 ASCO Annual Meeting, covering topics such as the prognostic ability of KIM-1 in kidney cancer, patient-reported outcomes from enfortumab vedotin/pembrolizumab treatment, and the final overall survival update from the JAVELIN Renal 101 trial. The conversation also delves into studies on IO/TKI biomarkers, adaptive trials with ctDNA, and the latest findings from trials like KEYNOTE-426, CLEAR, PSMAfore, and SURE-01. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

In this exclusive interview, Chadi welcomes Dr. Patrick Soon-Shiong, a Chinese immigrant who grew up under apartheid in South Africa and rose to become one of the world's most successful physician executives. Now the CEO of ImmunityBio, Dr. Soon-Shiong opens up about his remarkable journey. He shares what inspired him to pursue medicine, his entrepreneurial ventures, his move to the United States, and the story of his first investment. He discusses creating the groundbreaking chemotherapy drug Abraxane, which led to the formation of Abraxis, later acquired by Celgene, now part of BMS. He also expounds on his most recent FDA-approved drug, Anktiva, for bladder cancer. With complete candidness, Dr. Soon-Shiong reflects on his challenging upbringing, the discrimination he faced, and how he overcame these obstacles to achieve great success. He and Chadi explore life lessons, leadership styles, and a range of topics including Kobe Bryant, Gavin Newsom, COVID-19, the first pancreatic transplant, the acquisition of the Los Angeles Times, and his public feud with his brother. This 2024 podcast episode offers an unparalleled glimpse into the life of a highly public and inspiring figure and is one you’ll want to listen to more than once and share with everyone you know. Read more about Dr. Soon-Shiong. https://immunitybio.com/our-founder/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Drs. Balazs Halmos and Lecia Sequist delve into the groundbreaking updates from the 2024 ASCO Annual Meeting. With Chadi, they reveal game-changing insights on EGFR-mutated lung cancer from the LAURA trial, small-cell lung cancer upgrades from the ADRIATIC trial, important revelations in ALK mutation research, innovative combination therapies, ctDNA results from the ADAURA trial, and conclude with the relevance of the KRYSTAL-12 study. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Vivek Subbiah, MD, Chief of Early-Phase Drug Development at Sarah Cannon Research Institute, kicks off his new series on Healthcare Unfiltered, “VIVEK’S TAKES,” in which he will provide his expert feedback on the importance and lasting effects of research presented at the top medical conferences in the world. In response to the 2024 ASCO Annual Meeting, Dr. Subbiah shares the themes he sees being developed in multiple cancer subspecialties, including breast, lung, and pancreatic, as well as the research-driven benefits of receiving care on clinical trials and early palliative care via telemedicine. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is joined by Kate Dilligan, Founder and CEO of Cooler Heads Care, the manufacturer of a portable scalp cooling system authorized for adults 21 and older undergoing chemotherapy for a solid tumor. Kate shares her personal journey from being diagnosed with breast cancer to becoming an entrepreneur driven by a mission to help women undergoing chemotherapy mitigate the side effect of hair loss. Kate discusses the science behind the scalp cooling system and its effectiveness in preserving hair. She also delves into her innovative business model that supports infusion centers in remaining profitable, her journey in securing investors, and the future goals of Cooler Heads Care. Find out more about Cooler Heads. https://coolerheads.com/ Read Kate’s profile in Forbes. https://www.forbes.com/sites/maggiemcgrath/2022/12/28/meet-the-entrepreneur-helping-women-undergoing-chemo-keep-their-hair/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with David Krissman, a journalist and filmmaker whose passionate advocacy for kidney transplant and dialysis patients led him to create the groundbreaking podcast documentary series, "The Great Social Experiment." Krissman shares the harrowing personal story that inspired his film script, website, and podcast, exposing the stark financial incentives driving the U.S. healthcare system's approach to kidney transplantation and dialysis. Designed specifically for patients, his work offers crucial insights to help them navigate the often perilous landscape. The conversation broadens to address the challenges of routine clinical care, contrasting the U.S. system with those of other countries, providing a comprehensive look at the ongoing struggle for better, more equitable healthcare. Find out more about The Great Social Experiment. https://www.thegreatsocialexperiment.net/ Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Ronald Chapman, LLM, Shareholder and Chairperson of White Collar Defense & Government Investigations at Chapman Law Group, delves into the intricate intersections of law and daily life, highlighting the subspecialized nature of healthcare law and his primary areas of focus within this field. He offers insights into his strategic choices between judge and jury trials, providing a nuanced perspective on opioid prescriptions, and delineates the fine line between lawful and unlawful practices. Ronald also unpacks the complex legal nuances involved in cases of unlawful opioid prescriptions, offering listeners a deep dive into the legal challenges and considerations in these critical issues. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Shaalan Beg, MD, MBA, FASCO, and Noelle K. LoConte, MD, FASCO, join Chadi to delve into the contentious relationship between alcohol consumption and cancer. Drawing from their expertise and insights, they navigate through the complexities of discerning causation from association in this context, shedding light on why a randomized controlled trial might never conclusively prove this link. From deciphering the threshold of alcohol intake that elevates the risk of 7 types of cancer to addressing the challenge of convincing the public to heed the data, Drs. Beg and LoConte explore the nuances of risk assessment and drinking in social situations, including medical conferences. Read more about this topic. https://connection.asco.org/blogs/examining-controversy-surrounding-alcohol-promotion-oncology-events-virtue-signaling-or-cancer Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi is rejoined by special guest Dr. Pamela Kunz, Editor in Chief of the groundbreaking new publication, JCO Oncology Advances. Dr. Kunz, known for her expertise in gastrointestinal cancers, shares the story of how she landed the prestigious role, offering insights into the rigorous interview process. She discusses her innovative approach to generating interest in the peer-review process and outlines the journal's ambitious goals to promote open-access publishing and collaborate closely with the esteemed Journal of Clinical Oncology. With a wealth of experience, Dr. Kunz reveals the type of individuals who will comprise the journal's Editorial Advisory Board as well as the proposed new journal sections that are novel to medical publishing. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Chadi sits down with Dr. Chandana Banerjee, a trailblazer in palliative and hospice care, serving as the Dean, Director, and Designated Institutional Official of Graduate Medical Education at the City of Hope Comprehensive Cancer Center. With a remarkable career dedicated to improving end-of-life care, Dr. Banerjee shares insights on how to infuse every aspect of patient care with the same passion and hope found in palliative settings. From navigating the challenges of funding and visibility in the medical community to offering fellowship opportunities emphasizing communication nuances in this critical stage of care, Dr. Banerjee provides invaluable perspectives. Together, they shed light on common pitfalls healthcare professionals face in end-of-life care, strategies for breaking through patient denial, and much more. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/ Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA