Healthcare Unfiltered
The Science of Sequencing: When and Why
Oct 8, 2024
Dr. Joe Lennerz, Chief Scientific Officer of BostonGene and an expert in gastrointestinal and liver pathology, simplifies next-generation sequencing (NGS) for listeners. He discusses who benefits from NGS and its implications for treatment, including the challenges surrounding minimal residual disease (MRD) detection and liquid biopsies. The conversation also delves into the future of multi-cancer early detection technologies and the necessity for regulatory oversight in this fast-evolving field of healthcare innovation.
44:20
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Quick takeaways
- Next Generation Sequencing (NGS) significantly enhances cancer diagnostics by revealing genetic alterations, yet access remains limited due to various barriers.
- Minimal Residual Disease (MRD) testing is vital for monitoring treatment responses in cancers, especially in hematologic cases, but requires further research for solid tumors.
Deep dives
Understanding Next Generation Sequencing (NGS)
Next Generation Sequencing (NGS) is a revolutionary technology that allows for the rapid sequencing of genetic material, fundamentally changing cancer diagnostics and treatment. By deciphering the genetic code of cancers, NGS facilitates a better understanding of the genetic alterations that underlie tumor growth and can reveal vulnerabilities in certain cancer types. This technology has enabled researchers to make significant discoveries, linking specific genetic mutations to breast and lung cancers, which helps tailor targeted therapies. However, while the potential of NGS is substantial, it is crucial to recognize that most cancers have unique genetic characteristics that necessitate carefully designed treatment strategies.
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