This Week in Virology

Host: Vincent Racaniello Guest: Katherine A. High Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders. This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology. Links for this episode Katherine A. High, MD AAV gene therapy for congenital blindness (Sci Trans Med) Gene therapy for hemophilia (Hematol) AAV capsid decoys (Sci Trans Med) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea. Links for this episode Social media specialist position at ASM WHO dismisses Catholic church on vaccine safety U of T Dean resigns over anti-vaccine course (Tor Star) Vaccine Adverse Event Reporting System (VAERS) Countering anti-vaccination attitudes (PNAS) Designer ribosome (Nature) rVSV-EBOV preliminary report (NEJM) rVSV-EBOV phase III interim report (pdf, Lancet) World on verge of Ebolavirus vaccine (WHO) Ebolavirus vaccine in Africa (virology blog) Letters read on TWiV 349 11:55 This episode is sponsored by ASM GAP Weekly Science Picks Alan - Above and BeyondRich - DSCOVR (Dark moon side crossing Earth)Vincent - Stuxnet virus (Wired, YouTube) Listener Pick of the Week Konrad - Stated Clearly Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses. Links for this episode Virology tenure-track position at NCI (pdf) ASM Agar Art Contest Nigeria on brink of polio eradication (Nature) Dengue in Africa (Tyler Sharp) Permissive vaccines and virulence (PLoS Biol) Marek's disease vaccines and virulence (Ed Yong) Image credit Letters read on TWiV 348 This episode is sponsored by ASM GAP Weekly Science Picks Rich - Swan-Ganz catheter (Wiki, video)Vincent - Mobile DNA III Listener Pick of the Week Kevin - Synthetic prions Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus. Links for this episode Virology tenure-track position at NIH (pdf) 7:00 Voinnet investigation is a Swiss Federal secret (twitter) 12:25 Rose rosette disease in Ft. Worth (Star Telegram) 29:35 Rose rosette virus discovered (J Gen Virol) 34:25 Emeravirus (ViralZone) 33:55 Eriophyid mites (MI Botanical Garden) 32:40 Mite vector of rose rosette disease (U Florida) 34:55 Image credit Squirrel bornavirus associated with human encephalitis (NEJM) 38:40 Poll: How do you consume podcasts? 1:21:40 Letters read on TWiV 347 8:10, 59:40 This episode is sponsored by ASM GAP and ICAAC/ICC Time stamps by Jennifer. Thanks! Weekly Science Picks 1:17:05 Alan - National Immunization Awareness Month (Twitter campaign)Rich - Rosie Revere, Engineer by Andrea BeatyVincent - iPhone owns podcasts (9to5Mac) Listener Pick of the Week Sandra - World Zoonoses Day graphicPeter - Mammal-carnivorous plant mutualism (bat and shrew) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Joan Steitz This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation. Links for this episode ASV annual meeting, Western University Steitz Laboratory at Yale University Steitz Laboratory on Twitter Panoramic photo of ASV TWiV by Matt Evans Photos of ASV2015 (Facebook) Video of this episode - view at YouTube Weekly Science Picks Kathy - Charity HallRich - Ribosome binding sites of phage R17 mRNAVincent - Pluto flyby Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy. Links for this episode Virology faculty position, University of Toledo Weather and West Nile virus disease (AJTMH) B cell depletion benefits ME/CFS patients (PLoS One) Antibodies to influenza nucleoprotein cause narcolepsy (Science Transl Med) Letters read on TWiV 345 This episode is sponsored by ASM GAP - turn your science into a company Weekly Science Picks Dickson - Algal DMS releasing enzymeAlan - Science of beer agingKathy - The Art of Science winnersVincent - The future of Lego plastics Listener Pick of the Week Eric - Economics in One Lesson by Henry HazzilitStephen - The Martian by Andy Weir (audiobook) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Ruth Jarrett, Glen Nemerow, and Esther Schnettler At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts. Links for this episode Glasgow Science Festival microTALKS Hodgkin lymphoma (Histopath) HHV-6 and Hodgkin lymphoma (PLoS One) Adenovirus entry (PLoS Path) Adenovirus membrane penetration (Virology) Mosquito pathways that limit CHIK replication (PLoS Negl Trop Dis) Tick antiviral RNAi (Nucl Acids Res) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants. Links for this episode Prions in plants (Cell Rep) 11:35 Global influenza virus circulation (Nature) 20:40 Rough patch for plant RNA silencing (Lab Times) 29:50 Role of Argonaute proteins in plant viral defense (PLoS Path) 32:15 Rub-inoculation (YouTube) 42:45 Image credit Letters read on TWiV 343 4:00, 1:11:45 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:41:45 Dickson - Global rainfall and snowfall map and A Week in the Life of RainAlan - Automated patch clampKathy - More Women in Science mini LegosRich - The Martian trailerVincent - It's a bug's life Listener Pick of the Week May - p53 by Sue Armstrong Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime. Links for this episode Virus with A-form DNA (Science) Viruses in the extreme (virology blog) Sequelae of Ebolavirus infection (Lancet Inf Dis) Long term Ebolavirus effects (virology blog) Take the chili ME challenge Serological profiling of human viral infections (Science) Your viral past (virology blog) Letters read on TWiV 342 Timestamps by Jennifer. Thank you! Weekly Science Picks Dickson - Incredible photosAlan - Alone in a room full of science writersKathy - Calico cats and Siamese catsRich - Missing link in evolutionVincent - Podcasts saving NPR and Podcasting blossoms Listener Pick of the Week Jenny - What Bill Gates is afraid ofNeva - The Kardashian Index Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Adam Kucharski, Gillian Slack, and Emma Thomson Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa. Links for this episode Tribute to Richard Elliott Donate to mesothelioma research for Richard Elliott CVR science blog Photos of our visit Ceilidh goes viral! Video of this episode - view below or at YouTube Timestamps by Jennifer. Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv