This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation. Links for this episode Richard Elliott on TWiV 177 MERS-CoV outbreak, South Korea (ProMedMail) MERS-CoV serosurvey (Lancet Inf Dis) Biolabs in your backyard (USA Today) Constraints on measles virus antigenic variation (Cell Rep) Selection bias and bombers (John D. Cook) Virology (journal) Image credit: Cameron Moll Letters read on TWiV 340 Weekly Science Picks Dickson - Singapore Flower Dome and Cloud ForestAlan - Rescuing biomedical researchKathy - The value of basic researchRich - Virology 60th Anniversary IssueVincent - Careers in virology: Science writing and journalism Listener Pick of the Week Pritesh - How T cells kill cancer cellsRamon - The power of herd immunity Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination. Links for this episode Searching for Steamer in the oceans Lassa fever death in NJ (CDC and NYTimes) Transgenic mouse model for MERS-CoV (J Virol) First West Nile virus disease case in Texas Herpesvirus disrupts host transcription termination (Nat Comm) Sashimi plots Broad benefits of measles virus immunization (TWiM #104) Avian influenza outbreak (NPR) The virome in health and disease (Immunity) Image credit Letters read on TWiV 339 Weekly Science Picks Alan - Fooling millions into thinking chocolate helps weight lossKathy - Approaching PlutoVincent - ASM Agar art contest Listener Pick of the Week Daniel - FB pages you need to stop sharing from (one and two)Ken - Bird box science (canceled) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Kathy Spindler Guest: Laura Newcomb Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection. Links for this episode Neuron-specific mosquito antiviral mechanism (PLoS Path) Letters read on TWiV 338 Photos of our visit Video of this episode - view at YouTube Weekly Science Picks Laura - NP siRNA inhibits different influenza viruses (Antiviral Res)Kathy - Time-lapse miningVincent - Does the public trust science? Listener Pick of the Week Paul - Degree-Off XKCDPeter - Ebola containment, Hans Rosling, eLife podcast, Naked Scientists Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Michael Metzger and Steve Goff Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome. Links for this episode Hemocytic leukemia in soft shell clam (Sci Total Environ) Activation of Steamer in neoplastic hemocytes (PNAS) Transmission of clonal cancer cells in clams (Cell) Steve Goff on TWiV #76 Image credit Timestamps by Jennifer. Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids. This episode is sponsored by @ASM Conferences and ASM Microbe Links for this episode Life threatening influenza and IRF7 deficiency (Science) Whole exome sequencing (Wikipedia) Herpes encephalitis in children with Trif deficiency (TWiV 175) Avian influenza in the US (USDA, ProMedMail, CDC) Ebola eye (NEJM, NYTimes) Viral persistence (Virology lectures, pdf) Uveitis (National Eye Institute) Image credit Stability of Ebolavirus on surfaces (EID) Ignorance with Stuart Firestein (TWiV Special) Letters read on TWiV Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - Winogradsky time-lapseRich - Missing link in evolution of complex cellsKathy - GrantomeDickson - National Geographic Landscape Photo of the DayVincent - PyMol and Chimera Listener Pick of the Week Mauricio - Vax!

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants. This episode is sponsored by ASM Microbe and ICAAC/ICC Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine protects primates (Science) Biologically contained Ebolaviruses (PNAS) Ebolavirus is evolving but not changing (Virology) Ebolavirus not undergoing rapid evolution (Science) Letters read on TWiV 335 Timestamps by Jennifer. Thank you! Weekly Science Picks Alan - PinboardRich - Academic medicine investment in medical researchKathy - Tissue paper stop motion animationDickson - Do peer review panels select best science proposals?Vincent - MMR and autism: Still no association Listener Pick of the Week Ramon - Autism by MMR vaccine statusMehul - Ebolavirus disease courseJustin - Molecular Biology of Bacterial Viruses by Gunther S. Stent Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget. This episode is sponsored by SciMed Solutions and ASM Education. Links for this episode Pinot noir and viruses (Wine Spectator) 35:00 Endogenous florendoviruses (Nat Commun) 35:30 Sex and Ebolavirus transmission (WHO, CDC, NYTimes) 54:10 Ebolavirus waiting (NYTimes) 57:35 Canine influenza outbreak (ProMed, NorthStarVets) 1:01:10 Dr. Oz under fire (NYTimes) 1:06:20 TV doctors (Brit Med J) 1:09:50 Double the NIH budget (NYTimes) 1:11:45 Image credit: Grapes and Caulimovirus Letters read on TWiV 334 6:10 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:17:05 Alan - NIH RFI: How do we fix this mess?Rich - Editing embryos (PopSci, Prot Cell)Kathy - Creative class presentations (one, two, three, four)Dickson - The most tornadoesVincent - Apollo 13, 45 years later (Ars, IEEE, Farewell) Listener Pick of the Week Johnye - Rudolf and Leopold Blaschka Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program. Links for this episode MTGR1 and intestinal secretory lineage allocation (Faseb J) Coronaviruses induce macropinocytosis (mBio) PD-1 and respiratory virus reinfection (J Immunol) Vanderbilt MSTP on Facebook Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Seth Bordenstein, James Crowe, and Mark Denison Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses. Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two) 56:35 Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video of this episode: view at YouTube Timestamps by Jennifer. Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease. This episode is sponsored by SciMed Solutions and ASM Education. Links for this episode Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 Enterovirus D68 in Norway (Euro Surveill) 1:12:00 Unknown enemy (Nature) 1:10:40 Enterovirus D68 on TWiV 302 Letters read on TWiV 331 8:00, 1:23:50 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:53:50 Alan - OU0POLIO ham radio special event station (on air reports)Rich - Crane building itself (YouTube)Kathy - Vaccine heroes LEGO projectDickson - Life at the limitsVincent - Emperor of all Maladies film and Conference gender balance Listener Pick of the Week Jake - Designing useful microbes Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv