This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses. Links for this episode First worms, then viruses, now dormant cyber pathogens (Zdziarski blog) Guillain-Barré with Zika virus in urine (Eurosurveillance) Zika virus in urine, Brazil (J Clin Virol) Zika in pregnant women in Rio (NEJM) Issues with NEJM pregnant women study (Epi-Ramble) Zika virus and meningoencephalitis (NEJM) Zika virus and acute myelitis (Lancet) Person to person transmission of Zika virus (MMWR) Pyrethroids and mouse microcephaly (one, two) Zika virus illustrations (Visual Science) Cowpea mosaic virus at high resolution (Nat Comm) MIMIVIRE confers resistance to virophage (Nature) CRISPR in a phage (TWiM 56) National Academy of Sciences GoFoc meeting Image credit Letters read on TWiV 380 This episode is sponsored by ASM Agar Art Contest and Microbe Magazine Podcast Weekly Science Picks Alan - Progression of EvolutionDickson - Toddler dies of meningitisVincent - Gardasil ideology, not scienceKathy - The Noun ProjectRich - Physics Girl Listener Pick Mark - MyRadar app (iOS, Android) Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Scott Tibbetts Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature. Links for this episode Noncoding RNA required for establishment of latency (mSphere) 17:20 Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05 Zika virus in pregnant women in Rio de Janeiro (NEJM) 1:06:10 Zika virus infects cortical neural progenitors (Cell Stem Cell) 1:12:00 Image credit Letters read on TWiV 379 1:15:10 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25 Weekly Science Picks 1:42:45 Alan - Okeanos ExplorerDickson - Rome RebornVincent - Twitter Missing ManualScott - Best Science Images of 2015Kathy - Space Travel PostersRich - GoISSWatch Listener Pick Peter - Antibiotics and the Problem of the Broken Market Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Guests: Greg Smith and Mark Fuccio Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus. Links for this episode Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS) Releasing Zika virus data in real time (Nature) Zika virus infection and stillbirths (PLoS NTD) Zika virus infection, imported, Italy (Eurosurveillance) Letters read on TWiV 378 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast Weekly Science Picks Alan - Science byline counting projectDickson - Bill Nye on climate changeVincent - Zdziarski's blog of things (Apple's motion to vacate)Greg - Atlas, the next generationKathy - Sources of Chaco woodMark - How Dogs Love Us by Gregory Berns Listener Pick Bohdan - The real reason for brains Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans. Links for this episode Larvicide not involved in microcephaly (CBS News) Obama seeks $1.8b for Zika virus (Guardian) Zika virus in Puerto Rico (MMWR) Zika virus in semen (EID) Zika virus in Indonesia (EID) Phylogeny of Zika virus (EID) Zika virus may cause mental disease (NYTimes) Zika virus from amniotic fluid (Lancet) Host protein underlies avian influenza host restriction (Nature) Wendy Barclay on TWiV 177 Home to roost (Cell) Image credit Letters read on TWiV 377 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast Weekly Science Picks Alan - CDC vaccine quizDickson - A telescope so powerfulVincent - Virology Lectures 2016 (virology blog, iTunes U)Rich - Ion propulsion (Wiki)Kathy - Spurious Correlations Listener Pick Johnye - Magellan telescope and van Egmond photograpy at Kids Should See This Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jeremy Luban The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue. Links for this episode Ocular findings in infants with microcephaly (JAMA and Arq Bras Oft) Evidence of Zika virus infection in brain and placenta (MMWR) Zika virus associated with microcephaly (NEJM) Hard-core sequencing (Science) Zika virus and microcephaly (virology blog) Zika virus in the Americas (NEJM) JEV and WNV transplacental infections Rubella virus facts (WHO) Share your Zika virus reagents (virology blog) No link between anencephaly and Cache Valley Virus (EID) Image credit Letters read on TWiV 376 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016 Weekly Science Picks Alan - PhD Comics on gravitational wavesDickson - 25 years of HubbleVincent - Amazon AWS TOS and Confirming EinsteinRich - Mosquito mass productionKathy - TileAppJeremy - IL17A and autism and The Perfect Theory by Pedro Ferreira Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more. Links for this episode Zika outbreak in Brazil (EID) 13:40 Zika summary (ProMedMail) 19:30 Zika and microcephaly (MMWR) 27:30 Facts about microcephaly (CDC) Brazil Ministry of Health microcephaly numbers Zika spread in Americas (MMWR) Deu Zica 42:30 Microcephaly in Brazil (Lancet) 46:10 GM mosquitoes did not start Zika outbreak (Discover) 1:31:30 Debunking myths around Zika (Mad Virologist) Sexual transmission vs sexually transmissible (virology blog) 1:22:10 CDC Zika travel guidance 1:15:45 CDC on Zika and sex 1:17:10 Image credit: Esper Kallas, University of Sao Paulo Letters read on TWiV 375 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar Weekly Science Picks 1:50:45 Alan - Jetstream Online School for WeatherVincent - New virus watercolors from Michele Banks (one, two)Rich - The Mad Virologist (Facebook, blog)Kathy - Orcas in AntarcticaJeremy - Pardis Sabeti on TEDHelen - Science ValentinesCarolyn - Three letter word missing from Zika warnings Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma. Links for this episode Divergent requirements for removing VPg (mBio) Bond, covalent bond (TWiV 210) Link between malaria and endemic Burkitt's lymphoma (PLoS Path) Multifactorial role of malaria in Burkitt's lymphoma (PLoS Path) Plasmodium infection promotes AID-dependent B cell lymphoma (Cell) Children's cancer dependent on climatic factors (Nature) Denis Burkitt (Wikipedia) Request for PACE trial data (virology blog) Letters read on TWiV 374 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar Weekly Science Picks Alan - Indoor skydivingVincent - Cancer Virus by Crawford, Johannessen, and RickinsonRich - WitKathy - The Only Woman in the Room by Eileen PollackDickson - Show everyone your clinical data Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello Guest: Julius S. Youngner Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine. Links for this episode Trypsin for cell cultures (Proc Soc Exp Biol Med) Interferon induction by nonviral stimuli (J Gen Physiol) Interferons of different molecular weight (Proc Soc Exp Biol Med) Poliovirus thermal mutants (J Bacteriol) Combination of different cells in culture (Science) Equine influenza vaccine (Eq Vet J) Younger role in Salk vaccine (interview, amednews) Cutter Incident (JRSM) Video of this episode - coming as soon as I can get home! Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency. Links for this episode Ebolavirus update (ProMedMail) Influenza D virus (mBio) Vincent's influenza C virus paper (J Virol) Virus-like particles protect wasp eggs (Sci Adv) CMV protein foils cell defense against latency (Sci Adv) Image credit: Mark Letters read on TWiV 372 This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense Weekly Science Picks Alan - Go viralVincent - 3D virus popsicles (3ders, dangerous popsicles)Rich - Galileo thermometerKathy - Thing Explainer by Randall Munroe Listener Picks Christiane - Using PowerPoint to shine Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era. Links for this episode Second transmissible cancer in Tasmanian Devils (PNAS) New strains for production of IPV (PLoS Path) Synchronized switch to bivalent OPV (polioeradication.org) Virologists, start your poliovirus destruction (virology blog) Image is a painting by George Kush Letters read on TWiV 371 This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense Weekly Science Picks Alan - Skyfaring by Mark VanhoenackerVincent - Your Cells. Their Research. Your permission?Rich - NASA UV photos of the sunKathy - Aurora bike lightsDickson - Unfilled vials Listener Picks Kevin - John Oliver on nutritional supplementsJim - Tour of Australian synchrotron Send your virology questions and comments to twiv@microbe.tv