This Week in Virology

Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Kartik Chandran and Rohit Jangra Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Einstein goes viral (TWiV 314) Michael Rossmann, 88 (virology blog) Protocadherin-1 essential for New World hantavirus entry (Nature) Image credit Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Weekly Science Picks Alan - Temi and Trint Rich - Using Jupiter's moons to determine where on Earth you are Kathy- Best architecture in every state Vincent - Cyberwire Podcast: The Ghost and the Mole Kartik- Slack Rohit- Antibody responses to viral infections Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Hosts: Vincent Racanielloand Marion Koopmans Guests: Martin Beer, Stephan Gunther, and Vera Ros Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ECV2019 Partnerships not parachutes (TWiV 413) Fatal Borna disease virus infection in transplant recipients (NEJM) Sequencing of 2018 Lassa virus outbreak (Science) Zombie caterpillar behavior (Parasitol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate hosts (Virol) Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registrationends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agentin birds(Viruses) Novel deltavirus in snakes(mBio) SADS-coronavirusin piglets (Nature) Hosts and sources of endemic human coronaviruses(Adv Virus Res) Image credit Letters readon TWiV 546 Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Weekly Science Picks Alan - Plots of Data visualization tool Rich - How to control the brain; Meet UF Physician Kelly Foote, MD Dickson- Oceanix Kathy- Iceproofing large structures Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo Listener Pick Johyne- NYTimes Mag Lab (sorry, no link) Sheena - History of Vaccines by NPR Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the NEIDL video (YouTube) Timestamps by Jolene. Thanks! Weekly Science Picks Jens - Forvo pronunciation guide Brianne -How long do vaccines last? Alan- How much hotter is your home town than when you were born? Dickson- 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize virus inside cells (virology blog) Image credit Letters read on TWiV 544 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy- Preventing airborne disease (video and primary article) Vincent - The Mueller Report Listener Pick Steve- Vaccine Mythbusting Cyprian- Ten simple rules towards healthier research labs Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - How to Take a Picture of a Black Hole Alan- Jupiter Marbleimage Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut Dickson- Sky-High Stunners Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource Listener Pick Martin- Sydney Brenner passes Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps by Jolene. Thanks! Listener Pick Islam- How to successfully collaborate with industry Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- Where and when to see cherry blossoms Dickson- Nebraska floods Kathy- Peeps fungal infection experiment Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces Listener Pick Sam- STLR conversations Josh- Tree of Life Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Letters read on TWiV 540 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- The Quarters Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video] Dickson- How rats became an inescapable part of city living Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses Vincent - Why "chickenpox parties" are a terrible idea—in case it's not obvious Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv