This Week in Virology

The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - How to Take a Picture of a Black Hole Alan- Jupiter Marbleimage Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut Dickson- Sky-High Stunners Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource Listener Pick Martin- Sydney Brenner passes Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps by Jolene. Thanks! Listener Pick Islam- How to successfully collaborate with industry Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- Where and when to see cherry blossoms Dickson- Nebraska floods Kathy- Peeps fungal infection experiment Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces Listener Pick Sam- STLR conversations Josh- Tree of Life Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Letters read on TWiV 540 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- The Quarters Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video] Dickson- How rats became an inescapable part of city living Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses Vincent - Why "chickenpox parties" are a terrible idea—in case it's not obvious Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants (eLife) Image credit Letters read on TWiV 539 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Why Do So Many Scientists Want to be Filmmakers Alan- Better boarding method airlines won't use Dickson- Mass timber building Kathy- What organisms to study flow chart Vincent - World Pulls Andon Cord on 737 MAX Listener Pick Richard- The Real Cost of Knowledge Islam- 200 icosahedral viruses poster Mike- Post-Doc Me Now Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Wendy Mauryand Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TIM-1 is receptorfor Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death (J Virol) T cells and IL-10 in viral demyelination (J Neuroimmunol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Roald Dahl endorses measles vaccine Viruses encode ribosomal proteins (Nat Commun) Bat influenza virus receptor (Nature) Going to bat for flu research (TWiV 173) Letters read on TWiV 537 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Yes, I'm a Scientist on Twitter. Stop Judging Me. Alan- Impact of vaccines, graphed in heat maps Dickson- Treehoppers Kathy- World watershed maps Rich- Gene Machine by Venki Ramakrishnan Vincent - House hearing on measles outbreak (ASM comment) Listener Pick Jordan- Facebook may remove anti-vaccine recommendations Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals. Hosts: Vincent Racaniello and Alan Dove Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Cummings School of Veterinary Medicine Influenza virus in North Atlantic grey seals (Emerg Microbes infect) Influenza viruses in Alaskan wild birds (Emerg Inf Dis) Wild bird influenza virus replication in human cells (Infect Genet Evol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan- Your town's climate in 60 years Dickson- BMC Research in Progress Photo Competition Rich- NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - Watch a single cell become a complex organism in six minutes Listener Pick Anne- Pathogenesis II Kickstarter Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature) Calicivirus portal - long version (biorXiv) m6A modification and innate response (Nat Immunol) Brianne Barker's immunology course m6A modification and innate response (Genes Dev) Letters read on TWiV 534 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - The Red Queen's Race Card Game Alan- Pentax Papilio II Dickson- Felice Frankel on improving visual side of science Kathy- History of the alphabet chart (free download) usefulcharts.com (see blog, such as Latin Greek Cyrillic Venn Diagram) Vincent - Virology Lectures 2019 Listener Pick Peter- Microbehunter (YouTube, blog, forum) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv