This Week in Virology

Pulitzer Prize-winning author David Oshinsky discusses the history of poliovirus vaccines, including the rivalry between Jonas Salk and Albert Sabin, President Roosevelt's influence, and the impact of organizations like the March of Dimes. The podcast explores the challenges of researching and writing about polio, as well as the ongoing health challenges faced by polio survivors.

Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Kiki Warren Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bacteriophage DNA polymerase is primer-independent (PNAS) Primer-independent DNA polymerase from mobile elements (Cell Rep) Non-HBV helper viruses for HDV (Nat Comm) Waning of measles vaccine immunity (one, two, three) Letters read on TWiV 552 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Seek Rich - Want to See My Genes? Get a Warrant and NIH director will no longer speak on all-male science panels Brianne- Unique scientists Dickson- Vaccines - Calling the Shots Vincent- NY eliminates religious vaccine exemptions and Jessica Biel reveals that she does not understand vaccines Kiki- Converting type A to type O blood Listener Picks Justin - An Apple a Day Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Neuronal cell line supports herpes simplex virus latency (J Virol) Protect, modify, deprotect (PNAS) Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Quabbin Reservoir Rich - Katherine Swan Ginsburg Humanism in Medicine Program; The Arnold P. Gold Foundation Brianne- UPitt Measles Simulator Dickson- James Webb Space Telescope Vincent- Nobel Prizes and Life Sciences by Erling Norrby Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Kartik Chandran and Rohit Jangra Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Einstein goes viral (TWiV 314) Michael Rossmann, 88 (virology blog) Protocadherin-1 essential for New World hantavirus entry (Nature) Image credit Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Weekly Science Picks Alan - Temi and Trint Rich - Using Jupiter's moons to determine where on Earth you are Kathy- Best architecture in every state Vincent - Cyberwire Podcast: The Ghost and the Mole Kartik- Slack Rohit- Antibody responses to viral infections Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Hosts: Vincent Racanielloand Marion Koopmans Guests: Martin Beer, Stephan Gunther, and Vera Ros Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ECV2019 Partnerships not parachutes (TWiV 413) Fatal Borna disease virus infection in transplant recipients (NEJM) Sequencing of 2018 Lassa virus outbreak (Science) Zombie caterpillar behavior (Parasitol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager, Rachel Netzband, and Alex Ciota Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Five postdocs in North America (TWiV 194) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate hosts (Virol) Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details. Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registrationends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agentin birds(Viruses) Novel deltavirus in snakes(mBio) SADS-coronavirusin piglets (Nature) Hosts and sources of endemic human coronaviruses(Adv Virus Res) Image credit Letters readon TWiV 546 Timestamps by Jolene. Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Weekly Science Picks Alan - Plots of Data visualization tool Rich - How to control the brain; Meet UF Physician Kelly Foote, MD Dickson- Oceanix Kathy- Iceproofing large structures Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo Listener Pick Johyne- NYTimes Mag Lab (sorry, no link) Sheena - History of Vaccines by NPR Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the NEIDL video (YouTube) Timestamps by Jolene. Thanks! Weekly Science Picks Jens - Forvo pronunciation guide Brianne -How long do vaccines last? Alan- How much hotter is your home town than when you were born? Dickson- 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize virus inside cells (virology blog) Image credit Letters read on TWiV 544 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy- Preventing airborne disease (video and primary article) Vincent - The Mueller Report Listener Pick Steve- Vaccine Mythbusting Cyprian- Ten simple rules towards healthier research labs Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv