This Week in Virology

Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Host: Vincent Racaniello Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIH U19 grant mechanism $22 million Prometheus grant Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Host: Vincent Racaniello Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 22nd ESCV meeting Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate. Hosts: Vincent Racaniello, Rich Condit, and Nels Elde Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 4th Ringberg Symposium on Giant Virus Biology In-plaque mass spectrometry imaging (Nature Micro) Infection by brown tide virus, AaV (Front Micro) Choano virus with a rhodopsin photosystem (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Hosts: Vincent Racaniello Guest: Paula Stephan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How Economics Shapes Science Coalition for Next Generation Life Science Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: William Summers Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bill's ASV 2019 talk (PPT download) Inventing viruses (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Restoration of Western Flyer Rich - Purification of phage T7 RNA polymerase Dickson - The Galaxy is Not Flat Bill - Efficacy of tetravalent dengue vaccine Vincent - Blowout by Rachel Maddow Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene. Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - Spill the Beans vaccinated shirts Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Flublok (CDC) Adjuvant study of flu vaccines (NIH) Immunogenicity of quadrivalent Flublok (J Inf Dis) Monoclonal antibody response to Flublok (J Virol) Current flu vaccine recommendations (CDC) Double dose flu vaccine immunogenicity (Hum Vac Immunother) piRNA response on retroviral invasion of Koala genome (Cell) piRNAs rise to rescue Koalas (Cell) Image credit Letters read on TWiV 571 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - The Machinery of Life by David Goodsell Alan - Pomological watercolors Dickson - Wildlife Photographer of the Year Kathy - DiversifyMicrobiology DiversifyImmunology and Marmot becomes fox food Vincent - Burnet A Life by Christopher Sexton Listener Picks Justin - Worm with three sexes Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Hosts: Vincent Racaniello Guests: Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Aarhus University Findaphd.com Sensing incoming HSV-1 (J Int Cyto Res) Be careful of canons (TWiV 456) Polio and host genetics (Front Micro) TLR9 treatment of AIDS (AIDS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode New viruses that infect endangered wild salmon (eLife) Host serum iron modulates dengue virus acquisition by mosquitoes (Nat Micro) Image credit Letters read on TWiV 569 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Retraction of new CCR5/lifespan study Alan - Nomad Press illustrated science books, and illustrator Lex Cornell Dickson - RARE: Creatures of the Photo Ark Vincent - The Odyssey of Eradication by Thomas Abraham Listener Picks Justin - Mass spec pen Mark - What really brought down the Boeing 737 Max? Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv