This Week in Virology

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps Epidemiology of COVID-19 (China CDC) COVID-19 incubation period (J Med Virol) China clinical trials for COVID-19 (Nature) Furin cleavage site in SARS-CoV-2 spike (virology blog) Proximal origin of SARS-CoV-2 (Virological) Pangolin photos (Nat Geo) Letters read on TWiV 588 Timestamps by Jolene. Thanks! Weekly Science Picks Kathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Videocasts Day 1 Day 2 Listener Picks Stephen - This podcast will kill you Neva - China's surveillance Sophia - WHO online courses Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vector (Nat Med) Legacy of arbovirus hunters (Viruses) Electron microscopy for novel arboviruses (Viruses) Sylvatic dengue (Am J Trop Med Hyg) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China reacted too slowly to epidemic (NY Times) Wuhan rounds up infected (NY Times) 2019-nCoV asymptomatic transmission report flawed (Science) Mucus reduces effectiveness of alcohol gels (mSphere) SARS-CoV in feces (NEJM, Gastroenterology) Inadequate plumbing and spread of SARS-CoV (WHO) Persistence of virus on surfaces (one, two, three, four) Letters read on TWiV 586 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Mutation, Adaptation, and Virus Genomes Alan - The Comet Rich - Finding Your Roots: Science Pioneers Dickson - Let's Fill Our Cities With Taller, Wooden Buildings Vincent - Twenty-first century plague by Thomas Abraham Listener Pick Mark - Tracking CoV infections Sophia - Legislative approaches to immunization Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis) WHO Sitreps on 2019-nCoV Coronavirus overtakes SARS (SCMP) HHS press conference Discovery of 2019-nCoV (bioRxiv) Rich CoV genes in bats (PLoS Path) Early 2019-nCoV transmission dynamics (NEJM) Clinical features of early 2019-nCoV patients (Lancet) Remdesvir for MERS-CoV (Nat Commun) Transmissibility of 2019-nCoV (Imperial Coll, pdf) Comparison of R0 of pathogens (Guardian) Forecast of 2019-nCoV (WHO, Univ Hong Kong, pdf) Quammen on 2019-nCoV (NY Times) Benefits of handwashing (NY Times) Asymptomatic 2019-CoV transmission (NEJM) Summary of TWiV 584 Surgical vs N95 masks (JAMA) Letters read on TWiV 585 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Pandemic Alan - Educated by Tara Westover Rich - Star Trek: Picard Dickson - Highest Resolution Image Ever Taken of Surface of the Sun Kathy - Scientists make vampire bats 'glow' to simulate vaccine spread Vincent - Virology Lectures 2020 Listener Pick Edward - Virus snowflake designs Anthony - Microbe Hunting Autism to Zika Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet) Familial cluster of pneumonia caused by 2019-nCoV (Lancet) SARS-CoV 29 nt deletion reduces replication (Sci Rep) NSABB 2019 TWiV World Tour t-shirt Letters read on TWiV 584 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Library plug-in for Firefox or Chrome Rich - Sounds of the Solar Wind (Parker Solar Probe) Dickson - Stunning wildlife photos Kathy - Incomplete list of things that blow the minds of intro bio students Vincent - Mosquito photographs by Alex Wild (and anti-pick) Listener Pick Justin - YadaYadaYada virus Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 NJ ready to remove religious vaccine exemptions (Patch) New virus causing pneumonia in China (NY Times) New China virus is coronavirus (NY Times, ProMedMail) Weekly influenza cases (CDC) Future of influenza vaccines (Vaccines) Household influenza vaccine study (Int J Epidemiol) African swine fever (USDA) African swine fever infographics (one, two) Race for African swine fever vaccine (Scientist) 3D structure of African swine fever virus (J Biol Chem) Letters read on TWiV 582 Timestamps by Jolene. Thanks! Weekly Science Picks Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information Dickson - Australia Fires; Insect ecology; Smoke and aerosols Kathy - runcible Vincent - Without a Vaccine, These Are Your Odds Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Vaccines are safe and effective (Science) Microbiome perturbation alters response to flu vaccine (Cell) Successive blood meals aid virus dissemination in mosquitoes (Nat Micro) Letters read on TWiV 581 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody Alan - "Yah! Yah! Yah!" by Jack London, and the true story it's based on Dickson - Why whales are big but not bigger Kathy - Dual Axis Illusion Vincent - The Fall of the Faculty by Benjamin Ginsberg Listener Pick Suellen - Patient Zero podcast Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication. Hosts: Vincent Racaniello and Rich Condit Guest: Chris Sullivan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sullivan lab Virus-encoded miRNAs in papillomaviruses (PLoS Path) Murine polyomavirus miRNA promotes viruria (J Virol) DUSP11 helps XRN restrict hepatitis C virus (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Host: Vincent Racaniello Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PAN's labyrinth (Viruses) KSHV SOX protein DNAse activity (J Virol) Vertical flow immunoassay for pathogen detection (Talanta) Small RNA responses of mosquitoes (Insect Biochem Mol Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv