This Week in Virology

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 NJ ready to remove religious vaccine exemptions (Patch) New virus causing pneumonia in China (NY Times) New China virus is coronavirus (NY Times, ProMedMail) Weekly influenza cases (CDC) Future of influenza vaccines (Vaccines) Household influenza vaccine study (Int J Epidemiol) African swine fever (USDA) African swine fever infographics (one, two) Race for African swine fever vaccine (Scientist) 3D structure of African swine fever virus (J Biol Chem) Letters read on TWiV 582 Timestamps by Jolene. Thanks! Weekly Science Picks Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information Dickson - Australia Fires; Insect ecology; Smoke and aerosols Kathy - runcible Vincent - Without a Vaccine, These Are Your Odds Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Vaccines are safe and effective (Science) Microbiome perturbation alters response to flu vaccine (Cell) Successive blood meals aid virus dissemination in mosquitoes (Nat Micro) Letters read on TWiV 581 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody Alan - "Yah! Yah! Yah!" by Jack London, and the true story it's based on Dickson - Why whales are big but not bigger Kathy - Dual Axis Illusion Vincent - The Fall of the Faculty by Benjamin Ginsberg Listener Pick Suellen - Patient Zero podcast Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication. Hosts: Vincent Racaniello and Rich Condit Guest: Chris Sullivan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Sullivan lab Virus-encoded miRNAs in papillomaviruses (PLoS Path) Murine polyomavirus miRNA promotes viruria (J Virol) DUSP11 helps XRN restrict hepatitis C virus (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Host: Vincent Racaniello Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PAN's labyrinth (Viruses) KSHV SOX protein DNAse activity (J Virol) Vertical flow immunoassay for pathogen detection (Talanta) Small RNA responses of mosquitoes (Insect Biochem Mol Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Host: Vincent Racaniello Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NIH U19 grant mechanism $22 million Prometheus grant Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Host: Vincent Racaniello Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 22nd ESCV meeting Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate. Hosts: Vincent Racaniello, Rich Condit, and Nels Elde Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 4th Ringberg Symposium on Giant Virus Biology In-plaque mass spectrometry imaging (Nature Micro) Infection by brown tide virus, AaV (Front Micro) Choano virus with a rhodopsin photosystem (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Hosts: Vincent Racaniello Guest: Paula Stephan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How Economics Shapes Science Coalition for Next Generation Life Science Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: William Summers Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bill's ASV 2019 talk (PPT download) Inventing viruses (Ann Rev Virol) Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Restoration of Western Flyer Rich - Purification of phage T7 RNA polymerase Dickson - The Galaxy is Not Flat Bill - Efficacy of tetravalent dengue vaccine Vincent - Blowout by Rachel Maddow Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv