This Week in Virology

Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Aerosol and surface stability of SARS-CoV-2 (medRxiv) Clinical course and risk factors for COVID-19 (Lancet, pdf) Face mask use during SARS-CoV outbreak (EID) COVID-19 and Italy (Lancet) Letters read on TWiV 591 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Stanley Perlman answers CoV questions (Boston Globe) Fist bump (Am J Infect Control) Joint WHO-China report (pdf) Second coronavirus (LA Times) Response to second coronavirus (virological.org) COVID-19 animal models (STAT) Clinical predictors of COVID-19 mortality (Inten Care Med) CoV by the numbers (NY Times) Contamination of bar soaps (Microbios) SARS-CoV-2 vaccine timeline (NPR) How new vaccines are developed (GSK) SARS among critical care nurses (Emerg Inf Dis) How churches prevent SARS-CoV-2 spread (NPR) Image credit Letters read on TWiV 590 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy. Host: Vincent Racaniello Guests: Daniel Griffin and Valeria Cagno Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps How to Prepare for the Coronavirus (NY Times) Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) Cruise ship a/c could promote virus spread (Purdue news) Image credit Letters read on TWiV 589 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode WHO CoV sitreps Epidemiology of COVID-19 (China CDC) COVID-19 incubation period (J Med Virol) China clinical trials for COVID-19 (Nature) Furin cleavage site in SARS-CoV-2 spike (virology blog) Proximal origin of SARS-CoV-2 (Virological) Pangolin photos (Nat Geo) Letters read on TWiV 588 Timestamps by Jolene. Thanks! Weekly Science Picks Kathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Videocasts Day 1 Day 2 Listener Picks Stephen - This podcast will kill you Neva - China's surveillance Sophia - WHO online courses Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vector (Nat Med) Legacy of arbovirus hunters (Viruses) Electron microscopy for novel arboviruses (Viruses) Sylvatic dengue (Am J Trop Med Hyg) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China reacted too slowly to epidemic (NY Times) Wuhan rounds up infected (NY Times) 2019-nCoV asymptomatic transmission report flawed (Science) Mucus reduces effectiveness of alcohol gels (mSphere) SARS-CoV in feces (NEJM, Gastroenterology) Inadequate plumbing and spread of SARS-CoV (WHO) Persistence of virus on surfaces (one, two, three, four) Letters read on TWiV 586 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Mutation, Adaptation, and Virus Genomes Alan - The Comet Rich - Finding Your Roots: Science Pioneers Dickson - Let's Fill Our Cities With Taller, Wooden Buildings Vincent - Twenty-first century plague by Thomas Abraham Listener Pick Mark - Tracking CoV infections Sophia - Legislative approaches to immunization Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis) WHO Sitreps on 2019-nCoV Coronavirus overtakes SARS (SCMP) HHS press conference Discovery of 2019-nCoV (bioRxiv) Rich CoV genes in bats (PLoS Path) Early 2019-nCoV transmission dynamics (NEJM) Clinical features of early 2019-nCoV patients (Lancet) Remdesvir for MERS-CoV (Nat Commun) Transmissibility of 2019-nCoV (Imperial Coll, pdf) Comparison of R0 of pathogens (Guardian) Forecast of 2019-nCoV (WHO, Univ Hong Kong, pdf) Quammen on 2019-nCoV (NY Times) Benefits of handwashing (NY Times) Asymptomatic 2019-CoV transmission (NEJM) Summary of TWiV 584 Surgical vs N95 masks (JAMA) Letters read on TWiV 585 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne - Pandemic Alan - Educated by Tara Westover Rich - Star Trek: Picard Dickson - Highest Resolution Image Ever Taken of Surface of the Sun Kathy - Scientists make vampire bats 'glow' to simulate vaccine spread Vincent - Virology Lectures 2020 Listener Pick Edward - Virus snowflake designs Anthony - Microbe Hunting Autism to Zika Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet) Familial cluster of pneumonia caused by 2019-nCoV (Lancet) SARS-CoV 29 nt deletion reduces replication (Sci Rep) NSABB 2019 TWiV World Tour t-shirt Letters read on TWiV 584 Timestamps by Jolene. Thanks! Weekly Science Picks Alan - Library plug-in for Firefox or Chrome Rich - Sounds of the Solar Wind (Parker Solar Probe) Dickson - Stunning wildlife photos Kathy - Incomplete list of things that blow the minds of intro bio students Vincent - Mosquito photographs by Alex Wild (and anti-pick) Listener Pick Justin - YadaYadaYada virus Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv