This Week in Virology

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) SARS-CoV-2 screening before delivery (NEJM) SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) SARS-CoV-2 seroprevalence in homeless shelter (NEPR) Letters read on TWiV 603 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Recombination and mutation leading to SARS-CoV-2 (bioRxiv) Letters read on TWiV 600 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) Tiger at NY zoo positive for SARS-CoV-2 (NY Times) IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) Infection fatality rate for managing pandemic (virology blog) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Restricted dispensing of Plaquenil in NY state Virology of COVID-19 patients (Nature) Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_ Cloth face masks for all of US (NY Times) Masks and respiratory virus shedding (Nat Med) 50 million face masks to Japanese households (Kyodo News) More than you want to know about face masks (Slate Star Codex) Why is COVID-19 less severe in children? (virology blog) Tracking SARS-CoV-2 in sewage (UM) 1918 flattening the curve (Nat Geo) COVID near you Pandemic stops polio eradication (Science) SARS-CoV-2 vaccine patch in mice (U Pitt) Letters read on TWiV 595 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2. Hosts: Vincent Racaniello and Rich Condit Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Emergency use of hydroxychloroquine (FDA) Trial of hydroxycholorquine in COVID-19 patients (China, France) COVID-19 in critically ill patients, Seattle (NEJM) Feasibility of convalescent plasma therapy for COVID-19 (medRxiv) Letters read on TWiV 596 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tocilizumab (Wiki) Nares swab for SARS-CoV-2 (Star Trib) US SARS-CoV-2 epidemic curve (CDC) Cleaning and disinfecting (CDC) Cleaning fruits and vegetables (FDA) Coronavirus food safety (FDA) Vaccine development for SARS-CoV-2 (pdf) Image by Michele Banks Letters read on TWiV 595 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more. Hosts: Vincent Racaniello Guest: W. Ian Lipkin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Center for Infection and Immunity Control the Contagion videos Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv