This Week in Virology

Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in India (medRxiv) Letters read on TWiV 792 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Social Lives of Giraffes Kathy – Saturn's Iapetus, moon in 3-D Vincent – Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction by mRNA vaccine (Nature) T cell depleted macaques recover from SARS-CoV-2 infection (mBio) Letters read on TWiV 791 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Virgin Hyperloop shows off the future Brianne – BioNumbers Rich – Advice will evolve as COVID situation changes Alan – Mars Perseverance-themed geocaching swag Vincent – Mattel's Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls Listener Picks Nancy – Vaccines at a Party Jeff – How to Survive a Plague, Part 2 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Outbreak in Barnstable County, MA (MMWR) Kinetics of delta variant infections (medRxiv) Prophlaxis with Regeneron mAbs (Regeneron) Subcutaneous mAbs to prevent COVID-19 (NEJM) Variant neutralization by infection or vaccine antibodies (Clin Inf Dis) Remdesivir associated with longer hospital stays (JAMA) Post-acute sequelae (Op For Inf Dis) Letters read on TWiV 790 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence (one, two, three) Disease protection by non-neutralizing antibodies (Cell) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Nobel Prize Games Kathy – Snail sensors Rich – In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish Vincent – The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans. Listener Pick Jake – NASA spinoff Peter – Bernard, the Extraordinary Moth Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated people (NEJM) Letters read on TWiV 788 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Simone Biles and Suni Lee Brianne – How Speed and Distance Dictate the Way Olympians Run Rich – CDC reversal on indoor masking prompts experts to ask, 'Where's the data?' Vincent – Paul and the Mosquitos Listener Pick Lin – Your Vaccinated Immune System is Ready For Breakthroughs Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Updated mask guidance (CDC) Infections in public school district employees (MMWR) 10% of positive kids need hospitalization (Houston Chronicle) Effectiveness of vaccines vs delta variant (NEJM) Antibody response after third vaccine dose (JAMA) Severe COVID-19 in kidney transplant patients (Kidney Intl) mRNA vaccine protection with or without prior infection (medRxiv) Doxycycline ineffective (Lancet) Neurological manifestations (Lancet) Infections in vaccinated health care workers (NEJM) Letters read on TWiV 787 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letters read on TWiV 786 Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Science of Swimming Kathy – Talking to the vaccine hesitant and covidactnow.org Rich – The Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki) Vincent – Russia discards Pirs docking port to clear way for new space station module (IG post) Listener Pick April – Pemberton Aviation (Facebook, YouTube) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Genome of HSV1 from multiple sites in one person (J Inf Dis) Rotavirus disrupts calcium homeostasis (mBio) Rotavirus protein activates calcium sensor (J Virol) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Inside of Mars is not like Earth Brianne – AlphaFold Rich – Tesla motors Alan – Diving for antique beer Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Long COVID in children (JAMA) Outcomes after MIS-C (Pediatrics) Guidance for school opening (Amer Acad Ped) Infection in well traced delta outbreak (medRxiv) Immune memory 8 months post-infection (Science) Low dose mRNA vaccine enhances T cells (medRxiv) Protection after infection (Lancet) Assessment of BinaxNOW (Sci Rep) Rapid POC antigen tests (Cochrane Rev) Oral azithromycin ineffective (JAMA) Post discharge symptoms in Nigeria (AJTMH) Therapeutics for low and middle income countries (AJTMH) Letters read on TWiV 783 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv