This Week in Virology

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Scientific review articles as antivaccine disinformation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC)  Authorization for Vaccine in Young Children Filed (Moderna) Public Health Impact of Vaccines in US (BMJ) FDA authorizes first approved treatment for children (FDA) Phase 2 Data for Sabizabulin (Veru Pharma)  Clinical Characteristics of Post Infection Inflammation (The Lancet) Fact Sheet for Providers on Evusheld (FDA) Fact Sheet for Providers on Paxlovid (FDA) Provider Referral for EvuSheld (Northwell Health) Contribute to ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 895 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 (TWiV 879) Letters read on TWiV 894 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Apple AirTag Kathy – Dental art/sculpture/mobile/chandelier Alan – Vintage Radio and Communications Museum of Connecticut Vincent – For the Love of Enzymes by Arthur Kornberg Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prometheus project (TWiV 578) Reduced neutralization of South American yellow fever virus (Cell Host Microbe) Letters read on TWiV 893 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Earth Day and Earth Day History Brianne – XKCD: Family Reunion Vincent – Tokaido: A Journey (DVD) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune response to booster, 5-11 year olds (Pfizer) Children and vaccination (AAP) Hospitalization of 5-11 year olds (MMWR) Test using breath samples (FDA) Influenza virus, adenovirus, RS virus co-infections (Lancet) Booster crystal ball (TWiV 890) Bivalent vaccine (Res Square) Bivalent vaccine in mice (bioRxiv) Intramuscular Evusheld (NEJM) Global PASC (J Inf Dis) Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 892 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu virus from bats in Hungary (Nat Commun) Infectious Lloviu virus from DNA (PloS Path) Letters read on TWiV 891 Timestamps by Jolene. Thanks! Weekly Picks Brianne – APod Stars and Globules in the Running Chicken Nebula Kathy – BioRender Poster Builder Rich – The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey Vincent – Baumgartner Restoration Listener Pick J – Time, Einstein, and the coolest stuff in the Universe Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Cell Med) Letters read on TWiV 890 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Webb Telescope’s coldest instrument reaches operating temperature Brianne – Video of a CTL killing a tumor cell Rich – Our Unfinished Pandemic (On the Media Podcast) Vincent – Lý Thị Ca Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospital admissions during Omicron and Delta variant outbreaks (Lancet) Viral load in unvaccinated and vaccinated individuals (Nat Med) Predictive Capability of symptoms in children (Clin Inf Dis) Comparison of antigen tests (medRxiv) Incidence of Myocarditis after COVID19 and non-COVID19 vaccination (Lancet) Steroids during viral replication phase (Resp) Paxlovid efficacy and safety (Pfizer) Fluvoxamine & Outpatient Management (JAMA) Sabizabutin efficacy and safety (Veru) Colchicine and lack of benefit (Lancet) SARS-CoV-2 prevalence in Africa (medRxiv) Contribute to ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 889 33:35 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferrets (Nat Commun) Letters read on TWiV 888 Timestamps by Jolene. Thanks! Weekly Picks Brianne – BioRender Poster Builder Alan – Hexbug cat toys Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine Listener Picks Sue – American Visionary Art Museum Frazer – Vaccine trial for killer elephant virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 variant (bioRxiv) Scott Henley on influenza vaccine growth in eggs (TWiV 480) Fc receptor dependent entry of SARS-CoV-2 into monocytes (Nature) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Ketanji Brown Jackson confirmed to US Supreme Court Amy – Some threats just keep coming in waves Rich – Lady Bird Johnson Wildflower Center Vincent – Martijn Doolaard Listener Picks Ann – Immunological memory to SARS-CoV-2 infection and vaccines Chris – Isoplexis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv