This Week in Virology

TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 2023 Nobel Prize Physiology or Medicine (Nobelprize.org) Evading a toll on the road to mRNA vaccines (TWiV 860) Katalin Karikó‘s overlooked work (Wired) Accelerated mutation of SARS-CoV-2 in deer (Nat Comm) Letters read on TWiV 1051 Timestamps by Jolene. Thanks! Weekly Picks Dickson – The New City. How to Build Our Sustainable Urban Future Angela – 2023 Nobel Peace Prize Alan – The Ruin of All Witches, by Malcolm Gaskill Vincent – France kicks off bird flu vaccination despite trade backlash risk Listener Pick Charles – David Brooks and the $78 airport meal the internet is talking about John – Periodic Table of the Elements: Origins of the Elements AZ – Bronze statue of laboratory mouse knitting DNA in Russia Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged

TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Features of Long COVID (Nature) ERV envelope mediates feline copper homeostasis (Cell Rep) Letters read on TWiV 1049 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Webb spots a building block of life on Jupiter’s moon Europa Rich – Are we really made of ‘star stuff?’ Learn about your body’s elements Alan – Avian flu has reached the Galàpagos Vincent – Why the US can’t have nice things Listener Pick Az – Free solo Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospitalization with COVID-19 in the UK. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Molnupiravir-associated mutational signature in global SARS-CoV-2 genomes (Nature) Inhaled fluticasone furoate for outpatient treatment of COVID-19 (NEJM) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Distinguishing features of Long COVID identified through immune profiling (Nature) Early antibody treatment, inflammation, and risk of post-COVID conditions (mBIO) Autonomic dysregulation in long-term patients suffering from post COVID-19 syndrome (SR) Multiorgan MRI findings after hospitalization with COVID-19 in the UK (The Lancet) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1048 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 4:20 Postacute sequelae of COVID-19 at 2 years (Nat Med) Disability-adjusted life years (DALYs) (WHO) Respiratory droplet transmission of H3N8 virus (Cell) Letters read on TWiV 1047 Timestamps by Jolene. Thanks! Weekly Picks Dickson – UN Climate Action and California sues oil companies for exacerbating climate change Brianne – COVID Drugs are a Miracle Cure for Cats Rich – American Prometheus by Kai Bird and Martin J. Sherwin Vincent – Free Carl Zimmer writings Listener Pick Anne – She wrote to a scientist about her fatigue. It inspired a breakthrough. Alan – This Tiny Parasitic Wasp Can Drill Through Plastic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Wastewater surveillance data as a complement to tracking incidence of influenza A and RSV (CDC) Chatbot-delivered online intervention to promote seasonal influenza vaccination (JAMA) Temporal assessment of disparities in California COVID-19 mortality by industry (AOE) CDC/HICPAC’s plan to weaken guidance for health care respiratory protection and infection control (NNU) Modelling the impact of a high-uptake bivalent booster scenario on COVID-19 burden (The Lancet) Can high COVID-19 vaccination rates in adults help protect unvaccinated children? (ES) Paxlovid use and hospitalizations or death in previously uninfected high-risk population with COVID-19 (JID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Vaccination after developing long COVID (IJID) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1046 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Virologist Bob Lamb dies (Northwestern Now) Lassa virus mRNA vaccine (Nat Commun) CRISPR engineering of RNA viruses (Sci Adv) Letters read on TWiV 1045 Timestamps by Jolene. Thanks! Weekly Picks Angela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot (journal article) Brianne – The story of our universe may be starting to unravel Rich – Sunlight Changes Unequally All Year Long Alan – Arm swing asymmetry in overground walking Vincent – The Farm at the Javits Center Listener Pick Asal – Ig Nobel Prizes honor zombie spiders, rock-licking scientists, and a clever commode Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Environ) SARS-CoV-2 in mink and other animals (Transbound Emerg Dis) Mpox in Netherlands (EuroSurveill) Divergent SARS-CoV-2 in immunocompromised patient (Emerg Inf Dis) Accelerated SARS-CoV-2 evolution in deer (Nat Commun) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China’s health authorities fight surge in cases of unknown origin (BMJ) Analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses (ASHE) Prevalence and outcomes of co-infection between SARS-CoV-2 and influenza (IJID) Comparison of bivalent and monovalent mRNA vaccine boosters (CID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Acute blood biomarker profiles predict cognitive deficits after COVID-19 hospitalization (Nature) Temporal changes in fecal microbiota of patients infected with COVID-19 (BMC) Long-term survival after intensive care for COVID-19 (AIC) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1042 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv