This Week in Virology

TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Seasonality of endemic COVID-19 (mBio) Diversity of non-vaccine targeted HPVs (Cell Host Microbe) Wart’s up doc? (TWiV 126) Letters read on TWiV 1061 Timestamps by Jolene. Thanks! Weekly Picks Dickson – 2023 expected to be hottest year on record after warmest October ever Kathy – You can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably) Alan – Landmark case to get sanitation declared a civil right Vincent – SciComm Studios Listener Picks Charmaine – Petition fo National Science Appreciation Day Peter – Let’s eradicate polio this winter Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Stress in America 2023 (APA) CDC expands testing of international air traveler samples to include flu RSV, and other respiratory viruses (CDC) Missed opportunities for preventing congenital syphilis (CDC) Intrinsic and effective severity of COVID-19 case infected with BA.2 variant (JID) Masks during pandemics caused by respiratory pathogens (JAMA) Behavioral factors and SARS-CoV-2 transmission within a household cohort (Nature) Convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients (NEJM) Olfactory and gustatory function 3 years after mild COVID-19 (JAMA) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV on TWiV 1060 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Monoclonal antibody neutralizes all three poliovirus serotypes (Nat Comm) Blocking Ebolavirus intercellular spread (Cell Rep) Letters read on TWiV 1059 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Climate Science Angela – Spider Ballooning (Wikipedia) Kathy – Richard Harris Art Collection Rich – “The Murderbot Diaries” by Martha Wells Alan – Old Gods of Appalachia Vincent – Poetry Foundation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Routine vaccination coverage (CDC) Outbreak of invasive Group A Streptococcus in children (PIDS) Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 (Nature) Outcomes of SARS-CoV-2 omicron variant infections compared with seasonal influenza and RSV infections in adults (CID) Remdesivir is associated with reduced mortality in COVID-19 patients requiring oxygen (OFID) Effectiveness of nirmatrelvir/ritonavir against the development of Post–COVID-19 conditions among U.S. veterans (AIM) Contribute to our MicrobeTV fundraiser at PWB Letters read on TWiV 1058 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells. Host: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Klaus Früh Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) HCMV-based attenuated vaccine platform (Sci Rep) HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol) RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Health worker–perceived working conditions and symptoms of poor mental health (CDC) Neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet) Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy (JAMA) Duration of SARS-CoV-2 culturable virus shedding in children (JAMA) Prescribing outcomes in outpatients treated with PAXLOVID for COVID-19 (PLOS ONE) Nirmatrelvir and molnupiravir and post–COVID-19 condition in older patients (JAMA) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Intravenous vitamin C for patients hospitalized with COVID-19 (JAMA) Association between Guillain-Barré syndrome and COVID-19 infection and vaccination (NH) SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration (JIM) Transplanting candidates with COVID-19 (TID) Favorable experience of transplant strategy including liver grafts from COVID-19 donors (TID) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1056 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis. Host: Vincent Racaniello Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Lab worker contamination with SARS-CoV-2 plasmid DNA (J Clin Micro) Fractional dose poliovirus vaccine (Vaccine) No SARS-CoV-2 RNA in Vermont wildlife (Sci Rep) Predicting SARS-CoV-2 infectivity from RT-PCR (EMBO Mol Med) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged

From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals. Host: Vincent Racaniello Guests: Ron Fouchier, Rafael Medina, and Louise Moncla Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Centers for Influenza Research and Response Network Transatlantic spread of avian H5N1 influenza virus (Sci Rep) In-host diversity of influenza H5N1 virus (PLoS Path) Influenza H5N1 virus and mass mortality in sea lions (Vet Q.) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvir in patients with symptomatic COVID-19 (The Lancet) Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA) Antibiotic use among hospitalized patients with COVID-19 (OFID) One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19 Assessment of the available therapeutic approaches for severe COVID-19 (Nature) Optimal duration of systemic Corticosteroids in COVID-19 treatment (OFID) Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and in patients with long-COVID syndrome (Nature) Local budesonide therapy in the management of persistent hyposmia in suspected COVID-19 patients (JID) Safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with Kidney disease and COVID-19 Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1052 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv