This Week in Virology

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more. Links for this episode Poxvirus viability in historical relics (EID) TWiM 74: It came from the Siberian permafrost How to read a scientific paper Image credit: Not only quilts Letters read on TWiV 280 Weekly Science Picks Alan - Heartbleed explanationVincent - Agriculture science today podcastKathy - Quizlet flashcards (online and iTunes)Rich - Why nothing is truly alive Listener Pick of the Week Lance - Myles Power (YouTube and Facebook)Raihan - Cheap DIY microscopeGerald - DaVinci PressNeal - I'm a virus Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body. Links for this episode Retrovirus needed for stem cell identity (Nat Struc Mol Biol) HERV-H is a marker for pluripotency (Retrovirology) Letters read on TWiV 279 Weekly Science Picks Alan - HeathkitVincent - How to think about autism risk and Autism prevalenceKathy - Distortions Listener Pick of the Week Joseph - The real process of scienceMarion - ZometoolKevin - Audioimmunity and Emmunity Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1. Links for this episode Gene editing of ccr5 in AIDS patients (NEJM) HIV gets the zinc finger (TWiV 144) Genome engineering with zinc finger nucleases (Genetics) Photo credit: Watty's Wall Stuff Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe) Letters read on TWiV 278 Weekly Science Picks Alan - Digital scale model of solar systemDickson - Font of knowledgeVincent - Measles outbreaks trends, and NYC measles (one, two)Kathy - Winner, funding basic science to revolutionize medicine Listener Pick of the Week Stephen & Jon - Watty's Wall StuffJohyne - Macro views of snowflakesRicardo & Stephen - Vaccine exemptionsBill - Books by John JanovyMarshall - Animation of DNA replicationSteve - Debunking influenza vaccine myths Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Glenn Rall, Ann Skalka, and Vincent Racaniello Glenn and Ann meet up with Vincent to talk about his career in science and science communication. Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Susan Baker and Thomas Gallagher Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses. Links for this episode Papain-like viral proteases (Virus Res) MERS-CoV papain-like protease (Virology) Mouse model for MERS-CoV (PNAS) Receptor and MERS-CoV infection (J Virol) Letters read on TWiV 276 Video of this episode - view at YouTube Weekly Science Picks Vincent - First demonstration of Macintosh, 1984 Listener Pick of the Week Lance - The Signal and the Noise by Nate Silver Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life. Links for this episode Virocentric view of evolution (Curr Op Virol) Proposed order Megavirales (Arch Virol) Pithovirus (PNAS) Selfish virus-like elements (Virol J) Pandoraviruses are derived Phycodnaviruses (Biol Direct) Video of this episode - view below at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces. Links for this episode MERS-CoV in dromedary camels (EID) Virologist Al Kapikian dies Polio-like illness in CA (ProMedMail) Acute flaccid paralysis AFP in India (EID) Enterovirus 68 (MMWR) EV 68 CNS infection (Arch Path Lab Med) Polio-free does not mean paralysis-free (The Hindu) Viruses in 14th century coprolite (AEM) Coprolite and paleofeces Ancient poxvirus (EID) Giant coprolite (WordADay) Letters read on TWiV 274 Weekly Science Picks Alan - The science of science communicationRich - Command and Control by Eric SchlosserDickson - Top 10 plant virusesVincent - Is the Nobel Prize good for science?Kathy - Time to rethink graduate and postdoc education (YouTube) Listener Pick of the Week Jon - Lessons from a Kansas graveyardMike - Cross a fashion designer with a microbiologist Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: W. Ian Lipkin and Thomas Briese Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992. Links for this episode MERS-CoV in dromedary camels (mBio) TWiV 251: Don't kiss the camel TWiV 247: Today's weather in virology TWiV 239: Filterable camels Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection. Links for this episode Interferon lambda and HCV outcome (Cell Host Micr) Laser capture microdissection (Wikipedia) HCV dependent fluorescent reporter (Nat Biotech) Bats and viruses (PLoS Path) White nose syndrome (PLoS Path) Mouse phenome database Letters read on TWiV 273 Weekly Science Picks Rich - Think like a scientist (one, two); Science controversiesDickson - Visualization challenge 2013Vincent - Orphan BlackKathy - Alberta worm invasion project Listener Pick of the Week Timothy - How do vaccines cause autism?Anne - Luke Jerram's glass virusesJim - NLM Communications Engineering BranchSteve - Synapse by synapseJacob - Tiny technology creates a buzz Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene. Links for this episode Toxin delivery to plants by viral capsid protein (Nat Biotech) Pea enation mosaic virus (ViralZone) Image credit: Aphid membrane feeding chamber (Sci Rep) Aphid feeding chamber (YouTube) Parafilm (Wikipedia) Human endogenous retrovirus enhances neural gene (PNAS) Flu, common cold, alternative medicine (NCCAM) Cold vs flu (CDC) Phage hunters Bed bugs and infectious disease (PLoS Path) Letters read on TWiV 272 Weekly Science Picks Alan - Statistical error (Nature)Rich - 12 oldest animal speciesDickson - When liquids collideVincent - HIV denial and just asking questionsKathy - Sun's canyon of fire Listener Pick of the Week Sandra - Women physicists keep female students psychedJudi - HHMI's BiointeractiveJacob - Influenza virus HA Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv