This Week in Virology

Host: Vincent Racaniello Guests: Janet Butel and Rick Lloyd Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress. Links for this episode SV40 microRNAs (PLoS Path) SV40 seroprevalence (J Infect) Viruses and stress granules (PLoS Path) Viral inhibition of stress granule formation (Cell Host Micr) Video of this episode - view below or at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more. Links for this episode Varun's research poll Letters read on TWiV 289 Weekly Science Picks Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf)Kathy - Daily overviewDickson - Girl rising Listener Pick of the Week Johnye - Ri channelRicardo - Open spin microscope (Nikon gallery, plans)Chris - The microbiome game Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells. Links for this episode Should variola virus be destroyed? (poll at virology blog) DNA complementary to non-retroviral RNA viruses (Sci Rep) Integration of arenavirus DNA into cell genome (virology blog) Infectious respiratory syncytial DNA (PNAS) Tysabri and PML JC and PML (J Imm Res) Igor Koralnik laboratory Jean-Luc Doumont (Kathy's pick, TWiV 268) Bullet points kill (TED) Letters read on TWiV 288 Weekly Science Picks Rich - LuvalampsAlan - ExperimentVincent - American Society for Virology on FacebookKathy - LEGO female scientistsDickson - The Oldest Living Things in the World by Rachel Sussman Listener Pick of the Week Basel - A Treatise on the small-pox and measles by Abu-Bakr Al-Razi Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Matt Frieman Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens. Links for this episode MERS stories at CIDRAP MERS at CDC MERS in the US (CDC) MERS-CoV map MERS-CoV infection after camel exposure (EID) MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID) MERS-CoV antivirals (one, two, three, four) Experiments with novel potential pathogens (PLoS Med) Unacceptable risks (Bull Atom Sci) TWiX Bingo (thanks, Mark!) Letters read on TWiV 287 Weekly Science Picks Matt - Forgive me, scientistsAlan - Do not linkVincent - bioRxivKathy - Snail photographsDickson - Solar roadways Listener Pick of the Week Daniel - Benz Biome concept car Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Alan Dove Guests: Julie Pfeiffer and Paul Duprex Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus. Links for this episode Threading the NEIDL (YouTube) Transmission of measles virus from macaques (J Gen Virol) Tropism of green measles virus in macaques (J Virol) Intestinal microbiota promote enteric virus replication (Science) Bacterial LPS enhances poliovirus stability (Cell Host Micr) Video of this episode - view below or at YouTube Weekly Science Picks Vincent - ASM Live 2014Alan - I will not follow the herdPaul - Invisible ThreatJulie - The importance of stupidity in biological research Listener Pick of the Week Neil - WEHI movies and VIZBI Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: XJ Meng and Sarah McDonald Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses. Links for this episode Hepatitis E virus (Int J Env Res Pub Health) Porcine and human anelloviruses (J Virol) Origin of porcine epidemic diarrhea virus in US (mBio) Distinguishing rotaviruses (J Virol) Molecular epidemiology of rotaviruses (J Virol) Core domains in rotavirus polymerase encapsidation (J Gen Virol) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed. Links for this episode Skin scarification protects against vaccinia virus disease (J Virol) Smallpox research agenda (PLoS Path) WHO report on variola research (pdf) Review of smallpox research program for WHO (pdf) How I record my lectures (virology blog) Letters read on TWiV 284 Weekly Science Picks Rich - EPCOTVincent - Medical BiotechnologyKathy - Alan Alda interview and Flame Challenge winnerDickson - NASA live from space Listener Pick of the Week Nicola - 50 cent microscope (be a beta tester)Jon - Camtasia Studio Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jens H. Kuhn Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea. Links for this episode Review of Zanamavir clinical trials (Brit Med J) Ebola virus disease in Guinea (NEJM) Filovirus nomenclature (virology blog) Ebola virus disease, West Africa (ProMedMail) How lethal are ebolaviruses? (virology blog) Letters read on TWiV 283 Weekly Science Picks Alan - AMNH digital special collectionsVincent - Viral entry into host cells (Stefan Pöhlmann PhD, Graham Simmons PhD, eds)Kathy - Papilloma song lyrics (pdf)Jens - The Logic of Chance by Eugene V. Koonin Listener Pick of the Week Joe - Poor showing of 2012 influenza vaccine (Nature)Phil - Emerging disease or emerging diagnosis? (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws. Links for this episode World Malaria Day Review of oseltamivir clinical trials (Brit Med J) Effectiveness of Tamiflu questioned (NHS choices) Tamiflu campaign (Brit Med J) Rescuing US biomedical research (PNAS) Letters read on TWiV 282 Weekly Science Picks Alan - Northampton AirportVincent - Particle FeverKathy - Turn iPhone into microscopeRich - My favorite science gifs Listener Pick of the Week Nathan - The Ascent of Man (YouTube) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Peter L. Salk discusses the development of the first polio vaccine and Jonas Salk's legacy. Topics include childhood memories in Pittsburgh, career choices, challenges of vaccine testing, and the transition from oral to inactivated polio vaccine. The episode also explores the impact of a vaccine announcement on the scientist's family and the legacy of the Salk Institute.