MDS Podcast

Dr. Ruth Walker invites Prof. Emilia Gatto and Dr. Kevin Peikert onto the MDS Podcast for the second episode of the Chorea Special series. Together they discuss the general approach to patients with chorea of genetic etiology, with specific clues to diagnosis in terms of neurological and other features. They also discuss the nomenclature of neuroacanthocytosis syndromes, specific clues to the diagnosis in the clinical presentation and laboratory findings.

Dr. Eduardo Fernandez discusses with Dr. Hiroaki Sekiya the surprising findings of his study evaluating the presence of concomitant pathologies and how they impact the disease progression in a large cohort of patients with MSA from the Mayo Clinic brain bank. Read the article

Prof. Joseph Jankovic discusses the distinct characteristics of Chorea, including sudden, involuntary movements and twitch-y jerky motions. The podcast explores the diagnostic challenges in identifying hyperkinetic movements and emphasizes the importance of accurate diagnosis in differentiating between various disorders.

Prof. Romero Ramos discusses the immune system in Parkinson's disease, including immune cell alterations, biomarkers, vagus nerve connection, anti-inflammatory therapies, and future research advancements in personalized treatment approaches.

In this episode. Prof. Bas Bloem provides an overview of the topics covered in his lecture at the MDS-ES Focused Workshop: Diagnostic and Progression Biomarkers in Parkinson’s Disease and Atypical Parkinsonism, and discusses how biomarkers may help us identify patients and select adequate therapeutic strategies.

Dr. David Burn and Prof. Tiago Outeiro delved into the significance of biomarkers in Parkinson's disease, discussing challenges in implementation, genetic profiles, alpha-synuclein, and insights from a workshop on diagnostic and progression biomarkers, new therapies, and genetic research.

Prof. Olivier Rascol discusses gene therapy and cell transplantation for Parkinson's, advancements in therapeutic strategies, halting disease progression in Parkinson’s, and reliability of markers in neurodegenerative disorders.

In this episode, Dr. Hugo Morales interviews Dr. Bas Bloem and Dr. Victor Fung, co-authors of "The Wisdom of Our Mentors: Clinical Pearls in Movement Disorders," who share clinical pearls and discuss how mentors' and mentees' interactions are at the center of mentorship in movement disorders and the MDS. Read the article

In this Hot Topic episode, Dr. Michele Matarazzo interviews Dr. Nir Lipsman on the Focused Ultrasound-mediated Blood-Brain Barrier Opening, from technical challenges to current evidence and future perspective of this promising technology that could provide a new way to deliver drugs in the brain.

Prof. Paresh Doshi and Dr. Sara Schaefer discuss the outcomes of unilateral radiofrequency pallidotomy in focal and hemidystonia patients, comparing lesioning techniques like Gamma Knife Radiation Therapy and deep brain stimulation. They explore the effectiveness of pallidotomy in dystonia cases and the transition to deep brain stimulation, highlighting challenges in predicting patient results and the preference for radiofrequency lesioning over MRGFUS technology.