MDS Podcast

Dr. Michele Matarazzo interviews Dr. Robert Chen about the rapidly expanding applications of focused ultrasound-based neuromodulation in neurology, particularly in movement disorders, from tremor to Parkinson's disease. Tune in to uncover the future and potential of non-invasive neurotherapies that are setting new standards in research and patient care.

Prof. Tiago Outeiro interviews Dr. Jing Zhang on his most recent paper in the Movement Disorder Journal on the erythrocytic alpha synuclein and the gut microbiome. Together they discuss alpha synuclein spreading pathology and the promising future of blood biomarkers for Parkinson’s disease. Journal CME is available until March 02, 2025 Read the article.

Dr. Jussi Sipilä joins Dr. Eduardo de Pablo-Fernandez to discuss the interesting findings of the article on mortality rate in Parkinson's disease using nationwide data from multiple health registries in Finland. Read the article

Dr. Michele Matarazzo interviews Prof. Andrea Kühn on her recently published article showing the potential of local fields potentials to help the programming of deep brain stimulation in patients with Parkinson's disease. Read the article

Dr. Avenali and Prof. Valente discuss deep brain stimulation in GBA-related Parkinson's disease, highlighting its efficacy and risks. They delve into cognitive impacts, outcomes analysis, and the importance of genetic profiling for personalized treatment

Dr. Sara Schaefer discusses with Prof. Xiang Gao and Xinming Xu on their study utilizing the UK biobank to explore the risk of Parkinson's disease as it relates to family history of Alzheimer's disease (AD) or dementia and to the polygenic risk score for AD. They further explore the common pathophysiological underpinnings for protein aggregation in the brain. Read the article

Dr. Pasquini discusses the findings of his collaborative study that has helped to understand the progression of rest postural and kinetic tremor in Parkinson's disease. Read the article

Dr. Sara Schaefer discusses with Prof. Marc Vérin and Prof. Mahmoud Hassan their recent paper in Movement Disorders Journal on the use of Resting-State High-Density EEG to neurophysiologically stratify Parkinson's patients into subtypes in an effort to predict cognitive and motor progression, properly evaluate for invasive therapies, and inform future clinical research. Read the article

For this Hot Topics episode, Dr. Eduardo Fernandez sits down with Dr. Thomas Beach to discuss the advances and challenges ahead in tissue biomarkers for Parkinson's disease, including colon, salivary gland and skin biopsies.

Dr. Esther Cubo joins Dr. Sarah Lidstone and the MDS Podcast to discuss her recent work on the Spanish validation of the MDS Non-Motor Rating Scale. Together to go over the reasoning for this study, the extensive process of validating this scale and what benefits it will provide to Spanish speaking populations. Read the article MDS Non-motor Rating Scale