Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Addressing adverse food reactions goes way beyond simply cutting out the culprits, so I’m thrilled to have Dr. Tom Fabian join us again on New Frontiers to highlight the interventions that will move the needle for our patients. We explore the mechanisms through which specific strains can either exacerbate or alleviate both immune-mediated and non-immune-mediated food reactions, and discuss the fascinating connection between circadian rhythms of mast cells and intestinal permeability, feeding times and increased susceptibility to food reactivity. We look at why some patients may be more sensitive to symptoms and how histamine-producing microbes may lead to visceral hypersensitivity. But we also talk strategy, with one pearl after another, such as the potential of Lactobacillus reuteri in attenuating immune-mediated food reactions, the role of butyrate and indole in stabilizing mast cells, and using specific polyphenols to calm the immune system and promote a health microbiome. For any practitioner or health-savvy individual grappling with these issues, this is an episode you won’t want to miss. ~DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for the transcript, a COMPLETE LIST OF SHOW NOTES and all the FxMed resources. GUEST INFORMATION Thomas Fabian, PhD, CNTP https://tinyurl.com/5ehysjp7 Dr. Fabian serves as a translational science consultant and science advisor with Diagnostic Solutions Laboratory and is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. THANK YOU TO OUR SPONSOR Diagnostic Solutions Laboratory https://bit.ly/2IEhVrS *SPECIAL OFFER FOR FxMED LISTENERS* Download the GI-MAP Interpretive Guide at https://tinyurl.com/5ehysjp7 and use it to follow along with the episode. This practical guide from Diagnostic Solutions Laboratory can help you better understand and interpret test results for your patients. SHOW NOTES Understanding food allergy through neuroimmune interactions in the gastrointestinal tract https://tinyurl.com/2kstjrzp The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes https://tinyurl.com/5n7ymaj4 DSL Webinar: Neuroinflammation and the Gut-Brain Connection https://tinyurl.com/ykeeehnk Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions https://tinyurl.com/yhb5ddyc FxMED RESOURCES Gut Healing in Aging & Disease: Emerging Roles of the Microbiome and Diet in Intestinal Barrier Regeneration with Tom Fabian, PhD, CNTP https://tinyurl.com/h3rtumbs Hydrogen Sulfide in Health, Disease & Longevity with Dr. Tom Fabian https://tinyurl.com/25fmk83n Latest Insights into the Role of the Gut Microbiome in Healthy Aging with Dr. Tom Fabian https://tinyurl.com/bdz5u7vz CONNECT WITH DrKF Facebook: https://www.facebook.com/DrKaraFitzgerald/ YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc

Dr. Elisa Song is one of those clinicians that I could just keep talking to! She's a respected colleague and pioneer in pediatric functional medicine with so many practical tips for navigating childhood illness and health. Need to get your kiddo/patient through a blood draw they don't want to do? Or get your picky eater to take their supplement? Dr. Song has the answers. I appreciate her candor as she talks about how and why her practice has evolved in certain areas (such as in the use of targeted probiotics and even "psychobiotics" for autism, ADHD, anxiety, OCD and more) and in spelling out which supplement brands and doses she uses and why. Dr. Song tackles the immense challenges impacting the health of our kids and teens head on with positivity and smart, doable strategies for lasting success. This is a fascinating and empowering discussion with many clinical pearls that I will be implementing both in practice and for my own daughter going forwards. I hope you enjoy it too! ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. Guest Information Dr. Elisa Song, MD Healthy Kids, Happy Kids: An Integrative Pediatrician’s Guide to Whole Child Resilience: https://www.healthykidshappykids.com/book/ Healthy Kids, Happy Kids: https://healthykidshappykids.com/ IG: @healthykids_happykids FB: https://www.facebook.com/DrElisaSongMD/ Thank you to our sponsors Diamond Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z Gold OneSkin: https://tinyurl.com/ycxtw4zt TimeLine Nutrition: https://tinyurl.com/bdzx2xms Midroll Practice Better: https://tinyurl.com/28mmab99 Start your free trial and save 20% for 4 months on any paid plan with code KF20 Show Notes A Potential Decline in Life Expectancy in the United States…https://tinyurl.com/3frr8z6d Lost microbes of COVID-19: Bifidobacterium… https://tinyurl.com/r348tm78 Increasing Prevalence of Antinuclear Antibodies… https://tinyurl.com/7why9yrv Role of Bifidobacteria on Infant Health: https://tinyurl.com/4sk5u9ds Protective effect of Bifidobacterium infantis CGMCC313-2 on… https://tinyurl.com/2kn2vjnw Trends in Consumption of Ultraprocessed Foods Among US Youths… https://tinyurl.com/5fn5sce7 Dietary patterns, brain morphology and cognitive performance in children…https://tinyurl.com/mp5ekp26

Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out our show notes https://www.drkarafitzgerald.com/fxmed-podcast/ Guest information Anurag Singh, MD, PhDChief Medical Officer at Timeline Thank you to our sponsor Timeline Mitopure Research from Timeline care@timeline.com Timeline Discount for New Frontiers Listeners Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to Timeline and use the code KARA10 at checkout. Show Notes Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial https://tinyurl.com/fscfdd85 Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials https://tinyurl.com/2m2nzd56

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen approach. She's published research on her clinical outcomes and is continuing to gather more data for publication. The information and inspiration she shares are relevant to anyone dealing with cognitive decline, caring for someone with cognitive decline, or even those of us who want to preserve and optimize cognitive function as we move through life. I found her report that environmental toxins were one of the most common findings among her patient population illuminating. - DrKF Head to https://www.drkarafitzgerald.com/fxme... for the transcription and all the resources. Guest information Dr. Heather Sandison, ND, Author Reversing Alzheimer’s https://www.drheathersandison.com/ Email: drheathersandisonnd@gmail.com Thank you to our Sponsors Diamond Rupa Health - https://tinyurl.com/yc26f6sj Biotics Research - https://www.bioticsresearch.com/ Integrative Therapeutics - https://tinyurl.com/47sfktzb Gold OneSkin - https://tinyurl.com/ycxvz5we Mira - https://tinyurl.com/3pj4t338 TimeLine Nutrition - https://tinyurl.com/4bsdfczz Midroll Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - https://sites.practicebetter.io/new-f... Show Notes Reversing Alzheimer's by Dr. Heather Sandison :https://tinyurl.com/3hcywxxv Dr. Dale Bredesen: https://www.apollohealthco.com/dr-bre... Montreal Cognitive Assessment (MoCa): https://mocacognition.com/ Marama Residential Care Facility: https://www.maramaexperience.com/ Study: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline: https://www.ncbi.nlm.nih.gov/pmc/arti... Study: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project: https://www.ncbi.nlm.nih.gov/pmc/arti... DrKF Resources Podcast: Addressing Root Causes of Neurodegenerative Diseases with Dr. Dale Bredesen: https://tinyurl.com/3f2jchcm DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-... Younger You Group Program: https://www.drkarafitzgerald.com/youn...

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources. Guest information Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. Email: greg@neurohacker.com Facebook: https://www.facebook.com/neurohackercollective Instagram: https://www.instagram.com/neurohacker/ LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/ Qualia Discount for New Frontiers Listeners If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/4mst9py9 for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase. Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly Neurohacker Collective: https://tinyurl.com/3zpsaw3s Shape Shift: https://tinyurl.com/3zpsaw3s Alternative Medicine Review: https://tinyurl.com/56ad9av9 OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/ REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361 ASCEND Study - https://ascend.medsci.ox.ac.uk VITAL Study - https://www.vitalstudy.org/ Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f DrKF Resources Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/ Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/ Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/ Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/ Younger You book: https://youngeryouprogram.com/book/

I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that polyphenols need to be absorbed intact for benefit - there's plenty of evidence that their postbiotic products are very important players, especially in their interactions with the epigenome - his concerns about the chemical structure of highly concentrated fish oil supplements (with the potential for isomerization, as he argues) has opened my eyes and is important, without doubt. I think the jury is still out as to whether there is a negative influence of isomerization in highly concentrated EPA and DHA, but it's worthy of further investigation and (importantly) is another factor in the argument for a whole-food approach. - DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. Guest information Dr. Barry Sears, President, Inflammation Research Foundation and CEO of Zone Labs.Inc. Email: bsears@drsears.com Website: http://www.drsears.com/ Zone Living Website: http://www.zoneliving.com/ Inflammation Research Foundation: http://www.inflammationresearchfoundation.org/ Thank you to our Sponsors Diamond Rupa Health - https://tinyurl.com/yc26f6sj Biotics Research - https://www.bioticsresearch.com/ Integrative Therapeutics - https://tinyurl.com/47sfktzb Gold OneSkin - https://tinyurl.com/ycxvz5we Mira - https://tinyurl.com/3pj4t338 TimeLine Nutrition - https://tinyurl.com/4bsdfczz Midroll Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - https://sites.practicebetter.io/new-frontiers-in-functional-medicine Show Notes Dietary Control of Inflammation and Resolution - https://tinyurl.com/vadkjzf7 The STRENGTH trial - https://tinyurl.com/282cz27m OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/ REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361 ASCEND Study - https://ascend.medsci.ox.ac.uk VITAL Study - https://www.vitalstudy.org/ Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f

Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s personal and professional journey is a beacon of hope and empowerment, underscoring the significance of comprehensive care in women’s health. Prepare to be inspired by her dedication to revolutionizing fertility care and advocating for patient empowerment. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions). It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illustrates the incredible potential this technology brings for personalized evidence-based medicine, such as tailoring interventions based on microbial markers or targeting specific lifestyle changes for Alzheimer's prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my conversation with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth - that is, radically reverse our biological aging process to a younger time point without losing cellular identity. In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials. Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine. In this podcast - which is actually two-in-one because I continued the conversation with him on a second date - you’ll hear about the remarkable work they’re undertaking at his lab. For example: They’ve created a biological clock that encompasses the whole genome consisting of millions and millions of CpG sites. They are able to clearly demonstrate the reversal of bioage using their methodology - a cocktail of Yamanaka factors plus, with clear time limits - which changes the epigenome first, and in so doing influences all of the hallmarks of aging. Teaser: they’ve identified one intervention routinely used in clinical practice that influences their bio age clock in the same way that their cocktail does. What is it? I was riveted with this conversation, as I am sure you’ll be. Leave a review if you like it, and - Yes - let me know what you think. I know this will prompt deep questions for you, as it did for me. ~DrKF Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior education specialist at Diagnostic Solutions Laboratory, to New Frontiers to lead us on this discussion.Together, we'll take a deep dive into specific metabolites and pathways intricately linked to aging, mood, inflammation, and gut health and you’ll hear about equol, a rising star on the postbiotic scene. We'll even unravel some surprising insights from my own test results! Be sure to grab a copy of the Sample Report and pull up a seat for this fascinating discussion packed with valuable takeaways for yourself and your practice. ~DrKF You'll find it all at www.drkarafitzgerald.com/fxmed-podcast/