Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Dr. Valerie Gershenhorn, a top expert in functional dermatology, delves into the fascinating gut-skin axis. She discusses how digestive health significantly influences chronic skin conditions like acne and eczema. Insights on gut dysbiosis, the impact of stress, and innovative treatment strategies, including herbal remedies and dietary adjustments, are shared. The connection between oral health and skin conditions is also explored, highlighting the importance of a holistic approach to skincare. A must-listen for those seeking deeper skin health solutions!

Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-related dysfunction - even cardiovascular disease, as Dr. Greg Fahy points out in this New Frontiers podcast, is often caused by atherosclerosis driven by underlying chronic inflammation. I was thrilled to finally sit down with Dr. Fahy, whose groundbreaking work in aging has reshaped our understanding of what’s possible. His 2019 TRIIM study, showing clear epigenetic age reversal through thymus regeneration, was an absolute game-changer. The thinking prior to that was that epigenetic age reversal was not possible! It was exciting to read his publication as we were in the midst of our own original clinical trial. I'm sure you'll enjoy his recounting of that adventure and just how he's rejuvenating thymic function, the rationale for targeting immune rejuvenation, and the trial extensions he's currently working on now. ~ DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Greg Fahy, PhD https://tinyurl.com/3f4jww7j Chief Scientific Officer, Co-founder Intervene Immune https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt MIDROLL DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67 ONESKIN: Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at https://tinyurl.com/ycxvz5we SHOW NOTES Intervene Immune https://interveneimmune.com/ Reversal of epigenetic aging and immunosenescent trends in humans https://tinyurl.com/55dhx453 TRIIM-X Trial: Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial https://tinyurl.com/y65cu33p The Future of Aging: Pathways to Human Life Extension https://tinyurl.com/3hmbx29c

Cardiovascular disease might be the leading cause of death, but after my conversation with Dr. Mark Houston, I'm more convinced than ever that we have the power to change that narrative. We delved into the power of diet and lifestyle changes, the essential role of nitric oxide and the impressive results of innovative supplements like Vascanox HP by Calroy Health Sciences in managing blood pressure and cardiovascular disease risk. Dr. Houston's passion for prevention and the practical tips he shared made me feel hopeful and empowered. From understanding key tests to making everyday changes, this episode is all about giving you the tools to protect your heart health. Let's dive in and explore how we can all live longer, healthier lives. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Mark Houston, MD https://tinyurl.com/27thhcpr" Dr. Mark Houston is a Clinical Instructor at George Washington University. He is also Director of the Hypertension Institute and Vascular Biology and Medical Director of the division of Human Nutrition at St. Thomas Medical Group, St. Thomas Hospital and Health Services in Nashville, TN. He is on the faculty of A4M, for the FAARM and the Metabolic Medicine Institute (MMI) and George Washington University, and directs the Cardiovascular modules. He has also published seven best-selling books on vascular function. Dr. Houston has an active clinical practice, teaches, and does clinical research at St. Thomas Medical Group and Hospital. He founded the Hypertension Institute in 2000. THANKS TO OUR SPONSOR Calroy Health Sciences: Website New Frontiers Listeners, get your exclusive discount and resources from Calroy at http://calroy.com/drkf SHOW NOTES Hypertension Institute https://tinyurl.com/mr46hsph Metabolic Medicine Institute (MMI) https://tinyurl.com/2s39ryym Dr. Houston’s Study: Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide… https://tinyurl.com/4y5ndbjn About Vascanox HP https://tinyurl.com/543tamcj About Arterosil HP https://tinyurl.com/4fr6nbtc Ovationlab Vascular Support Protocol https://tinyurl.com/ynpdphmy Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients https://tinyurl.com/2c7xvwz2 Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association https://tinyurl.com/55shva8p CONNECT WITH DrKF on: YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/

What a tour de force conversation with Dr. Terry Wahls, who is, with her groundbreaking research, changing both conventional and functional medicine's approach to multiple sclerosis and ultimately patient care. I'm very excited to see the findings of her ongoing clinical trials, which evaluate the use of several popular dietary patterns, using MRIs to measure brain volume loss, microbiome data, metabolomics, and more. And folks, if you want to be a research participant there's still time - register your interest on Dr. Wahls' website here. In the podcast we also dive into long COVID, mental health challenges, autoimmunity, and explore treatments in the longevity and biohacking space, such as therapeutic plasma exchange, stem cells, and exosomes. Dr. Wahls has her finger on the pulse of what’s happening in the MS community, and you’re definitely going to want to listen to this one. Enjoy! ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Terry Wahls https://tinyurl.com/2ztnxbda Dr. Terry Wahls is an IFM Certified Practitioner and conducts clinical trials in the setting of Multiple Sclerosis. In 2018 she was awarded the Institute for Functional Medicine’s Linus Pauling Award for her contributions in research, clinical care, and patient advocacy. She is the author of The Wahls Protocol: A Radical New Way to Treat AllChronic Autoimmune Conditions Using Paleo Principles, and the cookbook, The WahlsProtocol Cooking for Life. Get involved in the clinical trial https://terrywahls.com/trials/ THANKS TO OUR SPONSORS DIAMOND Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase. MIDROLL DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67 ONESKIN: Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at https://tinyurl.com/ycxvz5we SHOW NOTES WahlsTM Diet Cheat Sheet http://www.terrywahls.com/diet The Wahls Behavior Change Model for Complex Chronic Diseases: A Clinician’s Guide https://tinyurl.com/mv47ww9k The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles https://tinyurl.com/2p9rn82j Efficacy of Diet on Fatigue and Quality of Life in Multiple Sclerosis: A Systematic Review and Network Meta-analysis of Randomized Trials https://tinyurl.com/y5ahbn5s The WAVES randomized parallel-arm clinical trial https://tinyurl.com/5c2rkufb

*Save the date! Join me and Dr. Alessandra Zonari for a free webinar on July 25th 2024 and get your questions answered on all things OS-01 peptide and biological aging. Register at https://www.drkarafitzgerald.com/webinars/ I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis. Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you’re using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Alessandra Zonari, PhD OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin’s biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals. Email: alessandra@oneskin.co THANKS TO OUR SPONSOR OneSkin: Website PROMO Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website SHOW NOTES Animated science video explaining how OS-01 works Another Study Website Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website MolClock: Estimate DNA methylation age of Skin Tissues Study Website Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

Practitioners, if specialized pro-resolving lipid mediators (SPMs) aren't already on your radar, you'll be a convert by the end of this New Frontiers episode. In functional medicine, we excel at addressing inflammation through nutrition and lifestyle. However, brilliant researchers like Dr. Charles Serhan from Harvard have shown us that resolving inflammation requires a two-phase approach. We need to shift gears, rally the cleanup crew, start the repair process, and turn down the volume on the immune system. This transition from inflammation to resolution is exactly what our guest, Ashley Koff, RD, will discuss. We'll explore why SPMs, discovered by Dr. Serhan, are crucial for healthy inflammation resolution and how Metagenics has developed a product using the patented Serhan method that has numerous clinical applications, from managing inflammation and pain to addressing neurodegenerative conditions, autoimmunity, and even infertility. We'll also delve into factors that influence our ability to convert omega-3 and -6 fatty acids into these superstar molecules, such as diet, genetics, inflammatory bias, and poor vagal tone. This conversation is packed with clinical pearls for your practice and personal use. Enjoy. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST INFORMATION Ashley Koff, RD is a 25+ year award-winning practitioner, founder of The Better Nutrition Program (est. 2019), and fractional Chief Nutrition Officer for entities like Vitaboom. Ashley Koff, RD | The Better Nutrition Program Phone: 323-251-7537 | Email: ashley@thebetternutritionprogram.com GUEST DETAILS Ashley Koff, RD: https://tinyurl.com/2drp29ky Founder - The Better Nutrition Program: https://thebetternutritionprogram.com/ Phone: 323-251-7537 Email: ashley@thebetternutritionprogram.com THANKS TO OUR SPONSOR: Metagenics: Website PROMO Get 15% off Metagenics SPM Active Supplement with Code SPMW624US (US) or SPMW624CAN (Canada) at checkout. https://tinyurl.com/4jc9np3y (Offer expires 7/15/24. Max order value $500. For consumer purchases only.) SHOW NOTES Metagenics Institute Study Website NFFM Podcast: Specialized Pro-Resolving Mediators (SPMs): As Close to a Panpharmacon as We Can Get? Another Study Website Latest Updates on Specialized Pro-Resolving Mediator (SPM) Science by Charles Serhan, PhD, DSc Another Study Website CONNECT WITH DrKF on: YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/

What if we could actually identify and even correct significant autism risk factors in utero, before a baby is born? This is the promise of the game-changing research of Dr. Janine LaSalle, epigeneticist extraordinaire from UC Davis. With autism rates continuing to increase at alarming rates (the latest data from the CDC, released in 2023, is 1 in 36 children in the US, an increase from the prior 1 in 44), new ways to prevent and treat this condition are of utmost importance. Dr. LaSalle is on a mission to change that, by investigating something you probably haven't heard much about yet - the placental methylome. Methylation signatures in the maternal placenta are yielding information both for predicting autism in children and for intervention targets to prevent the development of the disease. It's just incredibly exciting. In our conversation, you'll also learn how placental methylation behaves differently to DNA methylation in other tissues, and how the placental methylome may also help us better understand cancer as well as mechanisms that restore more youthful epigenetic patterns. Hold onto your hats folks - yes this is deep science, but it's also actionable even now. You'll hear how methylation support specifically in the early pregnancy window is key and how it's also protective against insults from environmental toxicants. You’re in for a treat with this fascinating conversation that has far-reaching implications for you and your patients. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. Guest Information Janine LaSalle, Ph.D. Professor, Medical Microbiology and Immunology, School of Medicine University of California, Davis jmlasalle@ucdavis.edu The LaSalle Lab at University of California, Davis Thank you to our sponsors Diamond Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z Gold TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase. Midroll Practice Better: https://tinyurl.com/28mmab99 Start your free trial and save 20% for 4 months on any paid plan with code KF20 Show Notes Perinatal Origins of Disparities Center: https://pod.ucdavis.edu/ Environmental Health Sciences Center: https://environmentalhealth.ucdavis.edu/ MIND Institute: https://health.ucdavis.edu/mindinstitute/ Article: Too Much Folate in Pregnant Women Increases Risk for Autism, Study Suggests: https://tinyurl.com/bdf9ez6k The human placental methylome: https://tinyurl.com/7zz8dz55 Markers of Autism Risk in Babies (MARBLES): https://tinyurl.com/49phe22r

Addressing adverse food reactions goes way beyond simply cutting out the culprits, so I’m thrilled to have Dr. Tom Fabian join us again on New Frontiers to highlight the interventions that will move the needle for our patients. We explore the mechanisms through which specific strains can either exacerbate or alleviate both immune-mediated and non-immune-mediated food reactions, and discuss the fascinating connection between circadian rhythms of mast cells and intestinal permeability, feeding times and increased susceptibility to food reactivity. We look at why some patients may be more sensitive to symptoms and how histamine-producing microbes may lead to visceral hypersensitivity. But we also talk strategy, with one pearl after another, such as the potential of Lactobacillus reuteri in attenuating immune-mediated food reactions, the role of butyrate and indole in stabilizing mast cells, and using specific polyphenols to calm the immune system and promote a health microbiome. For any practitioner or health-savvy individual grappling with these issues, this is an episode you won’t want to miss. ~DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for the transcript, a COMPLETE LIST OF SHOW NOTES and all the FxMed resources. GUEST INFORMATION Thomas Fabian, PhD, CNTP https://tinyurl.com/5ehysjp7 Dr. Fabian serves as a translational science consultant and science advisor with Diagnostic Solutions Laboratory and is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. THANK YOU TO OUR SPONSOR Diagnostic Solutions Laboratory https://bit.ly/2IEhVrS *SPECIAL OFFER FOR FxMED LISTENERS* Download the GI-MAP Interpretive Guide at https://tinyurl.com/5ehysjp7 and use it to follow along with the episode. This practical guide from Diagnostic Solutions Laboratory can help you better understand and interpret test results for your patients. SHOW NOTES Understanding food allergy through neuroimmune interactions in the gastrointestinal tract https://tinyurl.com/2kstjrzp The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes https://tinyurl.com/5n7ymaj4 DSL Webinar: Neuroinflammation and the Gut-Brain Connection https://tinyurl.com/ykeeehnk Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions https://tinyurl.com/yhb5ddyc FxMED RESOURCES Gut Healing in Aging & Disease: Emerging Roles of the Microbiome and Diet in Intestinal Barrier Regeneration with Tom Fabian, PhD, CNTP https://tinyurl.com/h3rtumbs Hydrogen Sulfide in Health, Disease & Longevity with Dr. Tom Fabian https://tinyurl.com/25fmk83n Latest Insights into the Role of the Gut Microbiome in Healthy Aging with Dr. Tom Fabian https://tinyurl.com/bdz5u7vz CONNECT WITH DrKF Facebook: https://www.facebook.com/DrKaraFitzgerald/ YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc

Dr. Elisa Song is one of those clinicians that I could just keep talking to! She's a respected colleague and pioneer in pediatric functional medicine with so many practical tips for navigating childhood illness and health. Need to get your kiddo/patient through a blood draw they don't want to do? Or get your picky eater to take their supplement? Dr. Song has the answers. I appreciate her candor as she talks about how and why her practice has evolved in certain areas (such as in the use of targeted probiotics and even "psychobiotics" for autism, ADHD, anxiety, OCD and more) and in spelling out which supplement brands and doses she uses and why. Dr. Song tackles the immense challenges impacting the health of our kids and teens head on with positivity and smart, doable strategies for lasting success. This is a fascinating and empowering discussion with many clinical pearls that I will be implementing both in practice and for my own daughter going forwards. I hope you enjoy it too! ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. Guest Information Dr. Elisa Song, MD Healthy Kids, Happy Kids: An Integrative Pediatrician’s Guide to Whole Child Resilience: https://www.healthykidshappykids.com/book/ Healthy Kids, Happy Kids: https://healthykidshappykids.com/ IG: @healthykids_happykids FB: https://www.facebook.com/DrElisaSongMD/ Thank you to our sponsors Diamond Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z Gold OneSkin: https://tinyurl.com/ycxtw4zt TimeLine Nutrition: https://tinyurl.com/bdzx2xms Midroll Practice Better: https://tinyurl.com/28mmab99 Start your free trial and save 20% for 4 months on any paid plan with code KF20 Show Notes A Potential Decline in Life Expectancy in the United States…https://tinyurl.com/3frr8z6d Lost microbes of COVID-19: Bifidobacterium… https://tinyurl.com/r348tm78 Increasing Prevalence of Antinuclear Antibodies… https://tinyurl.com/7why9yrv Role of Bifidobacteria on Infant Health: https://tinyurl.com/4sk5u9ds Protective effect of Bifidobacterium infantis CGMCC313-2 on… https://tinyurl.com/2kn2vjnw Trends in Consumption of Ultraprocessed Foods Among US Youths… https://tinyurl.com/5fn5sce7 Dietary patterns, brain morphology and cognitive performance in children…https://tinyurl.com/mp5ekp26

Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out our show notes https://www.drkarafitzgerald.com/fxmed-podcast/ Guest information Anurag Singh, MD, PhDChief Medical Officer at Timeline Thank you to our sponsor Timeline Mitopure Research from Timeline care@timeline.com Timeline Discount for New Frontiers Listeners Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to Timeline and use the code KARA10 at checkout. Show Notes Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial https://tinyurl.com/fscfdd85 Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials https://tinyurl.com/2m2nzd56