The Metabolic Classroom with Dr. Ben Bikman

Delve into the intriguing world of male menopause, or andropause, where testosterone gradually declines. Discover how mitochondrial health and insulin resistance sabotage testosterone production. Explore the vicious cycle of body fat converting testosterone into estradiol, leading to hormonal imbalances. Learn practical lifestyle interventions like resistance training and cold exposure to boost testosterone naturally. Uncover the delicate balance between hormone therapy and fertility. Gain insights into modifiable factors that support hormonal health.

Dive into the impressive benefits of long-chain omega-3 fatty acids, EPA and DHA, as they turbocharge fat loss and muscle growth. Discover why these animal-based sources are far more effective than plant-derived options. Learn how omega-3s stimulate mitochondrial biogenesis, enhance fat burning, and even improve muscle response to protein and insulin. Plus, they play a crucial role in preserving muscle during periods of disuse. Get practical dosing advice and unlock the secrets to maximizing your metabolic health!

Delve into the powerful role of ketones, specifically beta-hydroxybutyrate (BHB), in enhancing heart health. Discover how ketones act as an efficient energy source for the heart, especially during heart failure. They increase cardiac output and reduce the heart's workload by lowering vascular resistance. Learn about BHB's unique ability to promote vasodilation, improve circulation, and provide anti-inflammatory effects. Plus, explore practical strategies like ketogenic diets and exogenous supplements to boost heart resilience.

Dive into the debate of plant versus animal proteins! Discover how animal proteins are deemed 'complete' sources while plant proteins often lack key amino acids like leucine. Learn about the digestibility differences and the concept of DIAAS scoring. Unpack the issues with antinutrients found in plant foods that can hinder digestion and mineral absorption. Lastly, gain practical tips on how to safely incorporate plant proteins in your diet, especially regarding potential heavy metal contamination.

Dr. Bikman delves into the fascinating world of ketogenesis, revealing that women enter ketosis faster than men due to hormonal influences like estrogen. He explains how women exhibit higher free fatty acids and ketones during fasting, linked to their metabolic flexibility. While men, with greater lean mass, may ultimately lose more weight on ketogenic diets, the speed of ketogenesis varies significantly by sex. The discussion highlights the evolutionary implications of these differences and offers practical strategies for nutrition tailored to individual metabolic needs.

The podcast explores how concussions trigger a metabolic energy crisis in the brain, impacting glucose use and leaving neurons deprived of essential energy. Discover how ketones can provide a powerful alternative fuel source, improving energy production and reducing oxidative stress. The discussion includes evidence that ketogenic diets and exogenous ketones can enhance brain recovery and even serve as a preventive measure for athletes. Additionally, learn about the exciting potential for ketones to promote neuroplasticity and overall brain health.

Discover the fascinating world of plasmalogens, unique fats vital for cellular health. These compounds enhance insulin signaling, protect against oxidative stress, and help convert white fat into energy-burning beige fat. Delve into their role in mitochondrial efficiency and thermogenesis and learn how low plasmalogen levels correlate with metabolic disorders. Dr. Bikman also shares dietary tips to boost plasmalogen production, highlighting the benefits of DHA-rich foods and specific supplements for better metabolic health.

Discover the unexpected link between stress and ketone production. Dr. Bikman reveals how stress hormones like cortisol and epinephrine can boost fat-burning by triggering ketogenesis. He explains how the body’s response to stress mobilizes energy, turning fat into fuel, especially during low-carb diets. While acute stress can enhance metabolism, chronic stress has detrimental effects, leading to insulin resistance. Learn to harness stress for metabolic advantage while avoiding its pitfalls.

Discover the glycocalyx, a crucial sugar-rich layer that shields cells and regulates metabolic health. It plays pivotal roles in nutrient absorption, immune responses, and vascular functions. High blood glucose levels threaten its integrity, leading to inflammation and metabolic dysfunction. Learn how stressors can erode this protective barrier, resulting in leaky gut and influencing fat cell behavior. Dr. Bikman emphasizes the importance of maintaining balanced glucose to keep this unsung hero functioning optimally for better health.

Discover the pancreas's remarkable dual role as both an endocrine and exocrine powerhouse. Dr. Bikman dives into how insulin and glucagon work together to regulate metabolism and appetite. Learn about the secretion of digestive enzymes and the importance of their inactive forms for protection. Delve into the interconnectedness of pancreatic diseases like type 2 diabetes and pancreatitis. Finally, gain insights on lifestyle choices that support the health of this vital organ and maintain metabolic balance.