The Metabolic Classroom with Dr. Ben Bikman

Discover the remarkable metabolic effects of yerba mate, a South American tea packed with health-boosting compounds. Learn how it aids fat loss and improves insulin sensitivity, especially when paired with exercise. Delve into its role in activating AMPK, enhancing glucose uptake, and regulating appetite through the gut microbiome. The podcast highlights yerba mate's interaction with bitter taste receptors to promote hormone release and thermogenesis in fat cells, plus exciting unpublished findings on its impact on liver health.

Discover the fascinating phenomenon of anabolic resistance, where the body struggles to build muscle due to factors like aging and obesity. Dr. Bikman breaks down the key culprits behind this issue, such as reduced hormone levels and inflammation. He explains how the mTOR pathway influences muscle health and why amino acids are crucial. Plus, learn actionable strategies to combat muscle loss through resistance training and specific nutrient intake. Strength isn't just for aesthetics—it's vital for longevity and independence!

Dive into the intriguing world of the sugar diet, which surprisingly emphasizes simple carbs from natural sources while limiting protein and fat. This diet's philosophical roots date back to the 1930s rice diet, with claims of enhanced energy and improved metabolic health. However, the benefits seem to hinge on specific conditions and individual responses. The discussion also unveils the potential pitfalls of high-carb diets and protein restriction, along with the metabolic effects of fibroblast growth factor 21. It’s a thought-provoking examination of what truly fuels our bodies.

Dr. Bikman revolutionizes the understanding of type 1 diabetes by emphasizing the significant role of glucagon. He explains how glucagon can exacerbate hyperglycemia and ketone production when unregulated. This insight challenges the traditional focus solely on insulin deficiency. The discussion introduces promising therapeutic options like glucagon receptor blockers and GLP-1 agonists. Ultimately, there's a compelling call to rethink diabetes treatment as a bi-hormonal issue rather than just an insulin-centric one.

Delve into the surprising world of nitrates and nitrites, often demonized for their connection to processed meats. Discover their true role as metabolic allies, crucial for converting to nitric oxide and supporting vascular health. Learn how these compounds enhance mitochondrial efficiency and improve insulin sensitivity. The discussion challenges common cancer fears, emphasizing context and dosage. Explore the potential benefits of dietary nitrates found in vegetables for metabolic flexibility and overall health.

Explore how declining estradiol during menopause impacts brain function, muscle health, and inflammation. Learn about the protective role of beta-hydroxybutyrate (BHB) in enhancing cognitive health and reducing muscle loss. Discover the benefits of ketones for mitochondrial function and energy production, combating the adverse effects of hormonal changes. Plus, get insights on various ketone supplements like MCTs and their potential in managing menopause-related metabolic challenges.

Discover how the MTHFR gene affects your metabolic health and the crucial role it plays in methylation. Learn about the impact of genetic variants on homocysteine levels and their links to oxidative stress and insulin resistance. Uncover the connection between MTHFR, fat metabolism, and liver health, and how elevated insulin can disrupt fat burning. Get practical tips for optimizing folate intake from various sources and cooking methods to boost nutrient availability. Empower yourself with knowledge to navigate genetic vulnerabilities!

Explore the multifaceted benefits of creatine, a powerhouse for both muscles and the brain. Discover how it boosts ATP production and supports physical performance, recovery, and cognitive function. Learn about its role in enhancing glucose metabolism, particularly for those with insulin resistance. Dr. Bikman debunks myths around kidney health, clarifying that creatinine level increases are normal and safe in healthy individuals. Plus, get insights on optimal dosing and choosing the right form of creatine for effective supplementation.

In a deep dive into nattokinase, an enzyme from fermented soybeans, fascinating cardiovascular benefits emerge. It effectively dissolves blood clots, potentially outperforming traditional blood thinners with fewer risks. Studies reveal its ability to reduce plaque and improve cholesterol levels, while hinting at benefits for metabolic health and insulin sensitivity. The enzyme could transform our understanding of fat metabolism, making it a promising avenue for heart health. Yet, further research is essential to confirm these exciting findings.

Dive into a critical analysis of the claims made in a popular study promoting a plant-based diet. Hear about the misleading conclusions linking animal protein to diseases, and how higher meat consumption can actually coincide with lower cancer rates. Discover how dairy fats might protect against cancer while isolated protein studies distort health realities. Explore the mTOR pathway and learn why insulin is a better metabolic marker than previously thought. Get ready to rethink everything you thought you knew about diet and health!