Project 100 with Mark Bouris

In this episode, Mark sits down with Neal Mercado, Chief Science Officer at Melrose, one of Australia’s leading wellness brands. With a background in pharmaceutical sciences and more than 15 years in product formulation and clinical research, Neal brings rare insight into how supplements are actually developed, tested, regulated, and sometimes compromised. Neal most recently advised on the creation of FUTURELAB, a product range dedicated to the science of ageing well. Together, they unpack what works, what doesn’t, and what consumers need to know in an industry crowded with noise. This is a grounded conversation about longevity, metabolic health, and why scientific rigour matters more than ever. In this episode, we cover: • How supplement products are formulated and regulated• The real risks of adulteration and misleading labels • What a Chief Science Officer actually does• The science behind berberine and metabolic health • Why resveratrol remains controversial• The biggest challenges facing the supplement industry• How FUTURELAB approaches ageing well differently• The rise of personalised health and precision medicine• Where longevity science is heading nextSee omnystudio.com/listener for privacy information.

In this episode, Mark sits down with Sue-Ching Yeoh, an AHPRA-registered Oral Medicine Specialist with clinical appointments at Royal Prince Alfred Hospital and Chris O’Brien Lifehouse, and an academic role at the University of Sydney. This conversation goes far beyond dentistry. A/Prof Yeoh explains how the mouth acts as an early warning system for systemic disease, including autoimmune conditions, cancer, HPV, and chronic inflammation. She breaks down what gum disease actually is, why bad breath is often a medical issue rather than a hygiene one, and how lifestyle, genetics, vaping, smoking, and even social media trends are quietly damaging oral health They also cover practical, no-nonsense advice most people never hear: How to properly self-check your mouth The truth about tongue cleaning, salt water rinses, whitening, and sensitivity What tooth wear says about stress, nerve health, and aging When cosmetic treatments help and when they mask deeper problems Why early detection in oral health can be life-saving Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee. See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** I loved talking to these experts on Project 100 from all around the world, each bringing different backgrounds, experiences and perspectives. Who would you love for me to interview on Project 100 next? Here are some highlights from the standout episodes of the year: 0:00 – 10:45 — Gary Brecka10:46 – 24:57 — Jordan Sullivan (Fight Dietitian)24:58 – 32:06 — Dr Andy Galpin32:07 – 42:35 — Dr Steven Lu43:36 – 51:55 — Professor Sarah McKay51:56 – 1:04:43 — Dr Lila LandowskiSee omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr Lila Landowski is a neuroscientist, lecturer at the University of Tasmania, and the Vice President of Science & Technology Australia. In this episode, we break down the essentials of learning, memory, focus, and long-term brain health and what you need to stay sharp for life. We cover how the brain changes with age, what drives neuroplasticity, and why motivation, attention, repetition and stress all influence your ability to learn. Lila explains the key lifestyle levers behind cognitive performance, including exercise, nutrition, sleep, stress management and mindfulness.We also explore the impact of social media on developing brains, the broader responsibility of government and media in promoting brain health, and why “brain capital” is becoming a global priority. Lila closes with practical steps to protect your brain as you age and build long-term cognitive resilience.  The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.  One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep.See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Dr. Oliver Cronin joins me to unpack the truth about gut health, cancer prevention, and longevity.A gastroenterologist with a Fulbright scholarship from NYU Langone and fellowship training at Westmead Hospital, Oliver has seen firsthand how lifestyle and environment are reshaping Australia’s health. We talk reflux, the rise in bowel cancer among young Australians, and why colonoscopies remain one of the most powerful tools for early detection. He explains how AI is transforming endoscopy, detecting pre-cancerous cells with remarkable accuracy, and how preventative health programs like Everlab are changing the game. We also discuss what’s in your control: diet, fibre, exercise, and the tough conversations around alcohol and lifestyle. This is an unfiltered look at what’s really going on inside your body and how small, consistent changes can make the biggest difference to how long and how well you live. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee. See omnystudio.com/listener for privacy information.

In this discussion, Sebastian Mierau and Johannes Jess, co-founders of Clearlight Saunas, dive into the transformative power of infrared saunas and red light therapy. They highlight the science behind how these therapies enhance recovery and longevity, and discuss EMF safety measures. Listeners learn about the benefits of heat stress, such as improved cardiovascular health and pain relief. The duo also shares practical tips on sauna usage, optimal distances for red light therapy, and how these techniques can stack for better health outcomes.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** We all know water’s essential — but how safe is it, really? In this episode, I sit down with environmental scientist Professor Ian Wright to uncover what’s actually in Australia’s water, how it’s being treated, and what that means for your long-term health and longevity. From desalination plants and rural water systems to the growing threat of PFAS contamination, Professor Wright explains the hidden chemicals, the policies behind them, and how they can impact everything from your metabolism to disease risk. If you care about your health, your environment, and the future of clean water in Australia — this one’s for you. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee. See omnystudio.com/listener for privacy information.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. **** Today’s conversation dives into the world of genetics, prevention, and proactive health. I’m joined by Zoe Milgrom, co-founder of Eugene Labs, who is leading the charge in making genetic counselling and testing more accessible, affordable, and actionable for everyday people. We’ll unpack why genetic counselling matters, how the testing process actually works, and what it means for your healthspan. From real case studies to the future of preventative medicine, this episode explores how understanding your DNA could be one of the most powerful health decisions you ever make. Check out Eugene Labs website here: https://eugenelabs.com One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules   Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.   See omnystudio.com/listener for privacy information.

In this engaging discussion, Dr. Lila Landowski, a neuroscientist and lecturer from the University of Tasmania, delves into the science of stress and its surprising effects on longevity. She clarifies the difference between good and bad stress and shares mindset shifts to build resilience. Listeners will discover practical strategies for managing stress, improving sleep, and the critical role of social connections. Dr. Landowski also discusses the hidden downsides of alcohol and drugs while emphasizing the benefits of continual learning for cognitive health.

All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. In this episode of Project 100, Mark Bouris sits down with Dr. Emma Devenney, a cognitive neurologist and leading researcher at NEURA, to unpack what really happens to the brain during Alzheimer’s, dementia, and motor neurone disease. They discuss genetic risk, lifestyle factors, prevention, and the latest breakthroughs in treatment, including new therapies just approved in Australia. One product I’ve recently added to my routine from the Bulk Nutrients range is their NMN Extend. It’s a science-backed blend of 10 powerful ingredients, including NMN, Resveratrol, and Hyaluronic Acid, designed to support everything from energy and muscle recovery, to skin hydration, joint health, and event mental clarity. Check out their NMN extend product here: https://www.bulknutrients.com.au/products/nmn-capsules Eight Sleep’s newest generation, Pod 5. isn’t just another bed-frame add-on; it’s a high-tech mattress cover that actively adjusts to your body temperature throughout the night, cooling, warming, and even elevating your body when needed, all based on real-time data. The new Pod 5 introduces for the first time, a hydro-powered blanket system, utilising the same technology as the cover to extend temperature regulation across your entire body, not just the mattress surface. Clinically proven to increase quality sleep by up to one hour each night, it’s basically like having an AI-powered sleep coach, personal thermostat, and advanced health tracker working for you while you rest.  Head on over to eightsleep.com/project100 and use the code PROJECT100 (that’s Project one-zero-zero) and get up to $550 off your very own Pod 5. Trust me, your body will thank you for this investment in better sleep. The all-new WHOOP is here — now 7% smaller with 14+ days of battery life. New features like Healthspan show how your daily habits are affecting your rate of aging — and now you can check your blood pressure straight from your wrist. If you’re serious about performance, longevity, and actual progress — this is it. Sign up for a one-month free trial at WHOOP.com — or visit join.whoop.com/mentored for one month off your annual membership fee.   See omnystudio.com/listener for privacy information.