American Journal of Psychiatry Audio

Ms. Gal Arad (Tel Aviv University, Tel Aviv, Israel) discusses a non-pharmacological intervention for the treatment of social anxiety disorder in comparison with standard care. Afterwards, we'll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the May issue. Transcript Arad interview [00:18] What were your results? [02:11] Reduction in dwell time on threatening faces [03:36] Limitations [04:09] Immediate clinical implications [05:27] Further research [05:58] Kalin interview [06:37] Arad et al. [06:55] Grant et al. [09:07] Reddy et al. [10:59] Taipal et al. [13:28] Buchanan and Krane [14:39] Brandt et al. [15:41] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. David G. Amaral (University of California, Davis) is an author of a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder. He joins us on AJP Audio to discuss it. Afterwards, we'll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue. Transcript Amaral interview [00:56] Advantages and disadvantages of animal model research [02:14] What goes into determining which animals might be good candidates for research in human neurology? [04:52] How does basic research get translated into clinical treatments? [08:28] Alternatives to animal models [10:21] Promise of research moving forward [12:22] Kalin interview [15:30] Veenstra-VanderWeele et al. [15:46] Kato et al. [17:02] Zwicker et al. [19:17] Kim et al. [22:22] Zeng et al. [26:14] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants. Afterwards, we'll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue. Transcript Sachs interview [00:47] Why is treating major depressive disorder in patients proven to be such a challenge for clinicians? [01:54] Why cariprazine in conjunction with antidepressants? [02:37] Atypical antipsychotics and antidepressants [03:22] Atypical antipsychotics and side effects [05:23] Limitations [07:09] Clinical implications for the treatment of major depressive disorder [08:29] What's next for your research? [09:15] Kalin interview [10:09] Sachs et al. [10:25] Hasseris et al. [12:35] Visontay et al. [15:15] Dunlop et al. [17:10] Elbau et al. [19:56] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

This episode of AJP Audio features two articles from the February issue of AJP. First up, we have Nathaniel G. Harnett, Ph.D. (Harvard Medical School), discussing the impact of adversity and stress on racial disparities in childhood brain development among Black and White American children. Following that, Ziv Ben-Zion, Ph.D. (Yale University), discusses a non-exact replication study of a study published in AJP by Stevens et al. (previously featured on AJP Audio) looking at brain-based biotypes to guide treatment following trauma. And of course, we'll check in with AJP Editor-in-Chief Dr. Ned Kalin about the rest of the February issue and how it all fits together. Transcript Harnett interview [01:05] How do less tangible factors like trauma, stress, and exposure to violence impact brain development? [03:07] What do you mean by toxic stress? [04:41] Why did you choose to focus on those regions of the brain? [06:01] Regional variability and privacy concerns [07:50] Limitations [09:11] Future research [10:59] Children and the limited control of their environment [12:10] Ben-Zion interview [13:39] Challenges of running a non-exact replication study [15:12] Limitations [18:35] Should researchers consider replication in study design? [21:26] Future research [24:24] Kalin interview [27:46] Dumornay et al. [28:08] Baldwin et al. [30:02] Cleary et al. [31:38] Ben-Zion et al. [34:15] Hien et al. [37:08] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Stefanie Russman Block (University of Michigan, Ann Arbor) discusses a trial looking at whether connectivity patterns in the brain can be used to predict treatment response in patients with obsessive-compulsive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses childhood and neurodeveloment-related psychiatric disorders explored in the January issue. Russman Block interview [00:51] Exposure and response prevention versus stress management therapy [05:46] Investigating adolescents and adults [07:02] Clinical implications [08:29] Limitations [10:02] Further research [11:56] Kalin interview [12:57] Russman Block et al. [13:12] Webb et al. [14:57] Floris et al. [17:45] Shimelis et al. [21:27] Brikell et al. [26:04] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Rebecca Price (University of Pittsburgh) discusses a novel, computer-based intervention designed to extend the antidepressant effects of a single dose of ketamine. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue and what draws it together. Price interview [00:40] What does the computer-based intervention consist of? [03:55] Comparator arms [05:25] Are there immediate clinical implications? [08:04] Limitations [10:19] Further research [12:17] Kalin interview [14:02] Price et al. [14:28] Santos et al. [17:28] Grilo et al. [19:43] Solmi et al.v [22:51] Lam et al. [25:01] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Antonia Seligowski (McLean Hospital and Harvard Medical School) discusses how significant genetic correlations were identified between PTSD and cardiovascular disease as well as support for a causal link from PTSD to hypertension and coronary artery disease. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue and what draws it together. Seligowski interview [00:50] Genome-wide association studies [02:24] The Mass General Brigham Biobank [03:05] What were the limitations of the study? [04:05] Are there current clinical implications? [05:04] How does depression fit in? [06:11] Are the links between PTSD and cardiovascular disease linked to associated comorbidities? [07:00] What's next for your research? [07:52] Kalin interview [08:51] Seligowski et al. [09:06] Leone et al. [10:57] Hindley et al. [13:50] Lewis and Vassos [17:37] Sigström et al. [18:13] Brownstein et al. [20:32] In summary [25:03] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Richard Davidson (University of Wisconsin-Madison) discusses the effects of mindfulness training on the neural mechanisms of pain and what it means for the future of pain management. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses what draws together that paper and the rest of the October issue. Davidson interview [00:37] How do you go about investigating pain? [05:41] Lack of apparent difference in neural response among long-term meditators [06:45] What does this mean for pain management? [08:33] Limitations [09:46] Next steps for research [10:42] Kalin interview [11:50] Wieglosz et al. [12:01] Hasin et al. [14:25] Jutras-Aswad et al. [16:46] Lin et al. [19:08] Hasin et al. [20:36] In summary [22:34] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the October 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Lauren A. M. Lebois (Dissociative Disorders and Trauma Research Program, McLean Hospital, Harvard Medical School) discusses persistent dissociation following trauma exposure and whether it can be predictive of later psychiatric outcomes in at risk populations. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the September issue and what draws it together. Lebois interview [00:52] A prototypical adult dissociation case [01:51] Dissociation as a rollercoaster [05:48] The many ways of dissociation can be activated [08:04] Investigation through self-reporting and imaging [08:55] The imaging cohort [11:16] Biomarkers associated with dissociation and later psychiatric outcomes [11:54] Clinical treatment implications [15:09] Cambridge Depersonalization Scale and the Multidimensional Inventory of Dissociation [16:22] Limitations [16:57] What's next for your research? [18:01] Kalin interview [19:42] Lebois et al. [19:56] Gregersen et al. [22:33] Kendler et al. [24:58] Chand et al. [27:49] Jaffe et al. [31:45] In summary [34:39] Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the September 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Mark D. Shen (University of North Carolina, Chapel Hill) discusses the trajectory of brain development in infants at risk for autism spectrum disorder (ASD) and fragile X syndrome. Longitudinal imaging was captured from 6 to 24 months to see how brain development differed between groups, and the development of the amygdala in infants at risk for ASD prior to onset of social deficits and clinical diagnosis. Shen interview [01:03] Why look at patients with potential ASD diagnosis in conjunction with fragile X syndrome patients? [04:20] Why are differences in brain structure important? [05:46] What's the advantage of earlier diagnosis of ASD? [08:16] What's next for your research? [09:48] Kalin interview [11:47] Shen et al. [12:09] Girault et al. [15:30] Gerlach et al. [19:13] Mosholder et al. [22:12] Summary [25:31] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Transcript Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the August 2022 issue of AJP. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org