Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio, discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue.

Sachs interview [00:47]
Why is treating major depressive disorder in patients proven to be such a challenge for clinicians? [01:54]
Why cariprazine in conjunction with antidepressants? [02:37]
Atypical antipsychotics and antidepressants [03:22]
Atypical antipsychotics and side effects [05:23]
Limitations [07:09]
Clinical implications for the treatment of major depressive disorder [08:29]
What’s next for your research? [09:15]
Kalin interview [10:09]
Sachs et al. [10:25]
Hasseris et al. [12:35]
Visontay et al. [15:15]
Dunlop et al. [17:10]
Elbau et al. [19:56]

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March 2023: Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder