American Journal of Psychiatry Audio

Dr. Richard S.E. Keefe (Duke University Medical Center, Durham, North Carolina) discusses an article looking at an intervention for major depressive disorder that takes the form of a videogame. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the July issue's theme. Keefe interview: [01:00] What were your results? [03:13] What do videogames offer as a depression intervention? [03:43] Differences between the intervention and the control intervention [05:05] What was the impact of the interventions? [06:51] What were the limitations of the design and what might change going forward? [08:10] Does the patient's perception of the effectiveness of the intervention matter? [09:20] How the intervention differs from a similar intervention aimed at children [10:19] Is there an advantage to "hiding" the intervention as a videogame? [11:33] Designing a game and an intervention that work simultaneously [13:27] What next for your research? [15:05] Kalin interview [16:11] Keefe et al. [16:22] Tabuteau et al. [18:15] Ge et al. [20:54] Pan et al. [22:01] Tamm et al. [23:47] Pizzagalli [25:30] Grogans et al. [26:02] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

AJP Editor-in-Chief Dr. Ned Kalin discusses the June issue with guest editor Dr. Crystal Barksdale (National Institute on Minority Health and Health Disparities). The issue focuses on mental health disparities, the pervasive negative consequences of structural racism, and the importance of community-wide and systemic interventions. Barksdale interview [00:30] How do mental health disparities differ for minoritized groups? [04:10] Structural and institutional racism as a factor in mental health disparities [05:53] Why have structural factors been largely ignored? [08:37] Alvidrez and Barksdale [11:03] Alegria et al. [13:11] Keeping review committees and reviewers up to date [15:11] Hankerson et al. [16:53] Developing research strategies based on the needs of the community [18:09] Alvarez et al. [20:22] What can the journal do to push these issues forward? [22:19] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Kenneth Kendler (Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University, Roanoke, VA) discusses the history and emergence of psychiatry as a discipline, and how the conception of mind, body, and soul evolved. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses the May issue of AJP, and the past, present, and future of psychiatry. Kendler interview [00:45] Why is it important to look at the history of psychiatry? [10:28] The emergence of mental asylums [12:58] The mixed legacy of asylums [16:24] What's next? [18:07] Kalin interview [21:14] Brennand [23:07] Erwin and Weinberger, Cruceanu et al. [24:29] Pretzsch et al. [26:04] Roberts et al. [27:17] Meier et al. [28:52] Pedersen et al. [32:02] In conclusion [33:55] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Brian Kelly (Purdue University, West Lafayette, Indiana) discusses a study that found recent efforts to curb opioid prescriptions appear to have had an effect on reducing prescription opioid misuse and dependence, with no evidence that shifts in local-level opioid dispensing affected odds of heroin use, frequency of heroin use, or heroin dependence. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together. Kelly interview [00:30] Why county level data? [01:22] What accounts for the variation between counties? [02:28] Decreased prescription rates did not lead to increased heroin usage [04:07] How do we ensure the needs of those who need pain management? [04:55] What should happen with opioid dispensing practices? [06:10] National Survey on Drug Use and Health [07:30] Next steps [08:35] Kalin interview [09:34] Vuolo and Kelly [09:58] Watts et al. [11:25] O'Keeffe et al. [14:25] Sohal [17:35] Chung et al. [18:35] Summary [23:05] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Giovanna Punzi and Dr. Daniel Weinberger (Lieber Institute for Brain Development, Baltimore, Maryland) discuss findings from their new paper, "Genetics and Brain Transcriptomics of Completed Suicide," which looks at differences in the brains of those who die by violent versus less violent means of suicide. Afterwards, Journal Editor-in-Chief Dr. Ned Kalin discusses what pulls the March issue of AJP together. Punzi and Weinberger interview [00:43] What made the two categories distinct? [02:28] Aggression as a factor [03:43] Differences in genetic factors [04:58] Potential heterogeneity of suicide [06:28] Counterintuitive conclusions [07:42] Clinical implications for those at risk for suicide [11:00] Next steps for research [11:43] Kalin interview [12:56] McMahon [13:58] Jacquemont et al. [14:22] Mancini et al. [15:53] Mahjani et al. [18:40] Leckman [21:22] Punzi et al. [21:48] Ecker et al. [25:38] Summary [28:45] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Margaret Sibley (University of Washington, Seattle, WA) joins the podcast this month to discuss an article from the February issue of the Journal looking at patterns of remission in attention deficit hyperactivity disorder in children. Dr. Ned Kalin, Editor-in-Chief of AJP will join us afterwards to discuss the rest of the February issue of the Journal. Sibley interview [00:51] What does "full remission" from ADHD mean? [01:54] Variable patterns of remission in children with ADHD [02:33] The DSM definition of ADHD and the impact of ADHD symptoms [04:10] Advantages and disadvantages of using longitudinal data [06:50] What does the pattern of intermittent remission mean for treatment of ADHD? [09:39] What does this suggest for further research into ADHD diagnosis and treatment? [11:08] How does this affect treatment going forward? [12:48] Kalin interview [15:25] Flavin et al. [16:04] Sibley et al. [16:45] Markowitz et al. [18:20] Tadmon and Olfson [19:07] Manfredi et al. [20:30] Morgan et al. [22:39] Cole et al. [24:57] In conclusion [29:03] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

In this month's AJP Audio, Dr Margert Haney (Director of the Cannabis Research Laboratory at Columbia Psychiatry) discusses her new review from the January issue of the American Journal of Psychiatry, "Cannabis Use and the Endocannabinoid System: A Clinical Perspective," and the questions around the legal status of cannabis research. Afterward, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the January 2022 issue of AJP. Haney interview: How does cannabis interact with our brains? [00:30] CBD and how it's different [01:26] Impact of state legalization of cannabis on research [02:08] Federal attitudes towards cannabis legalization [03:43] A single source of cannabis for research [04:57] Limitations on research and an expanding, unexamined market [06:11] Marketing of other cannabinoids [06:38] Consequences of cannabis legalization [08:06] Cannabis use disorder [08:36] What happens with daily cannabis use – and abrupt cessation? [09:27] What happens to your endocannabinoid system with daily use? [10:36] A proliferating market and constrained research [11:56] Patients foregoing FDA-approved medication in favor of cannabis products [12:14] There's a reason we have randomized controlled clinical trials with placebo [12:37] Changes in cannabis use and abuse [13:31] Public perception of cannabis use disorder [14:26] What's next for cannabis research? [15:20] Loosening of cannabis sources [16:03] No US source for CBD to study [16:36] Future changes in the status quo? [17:24] Importance of the endogenous cannabinoid system [18:41] Potential consequences during vulnerable times in brain development: in utero and adolescence [19:08] Marketing cannabis to pregnant women [19:45] Kalin interview [20:30] Alcohol and cannabis use disorders [20:39] Haney [21:43] Browne et al. [22:34] Livne et al. [23:31] Mellentin et al. [25:38] Mallard et al. [27:39] In sum [28:30] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

In this month's AJP Audio, Dr. Samuel Wilkinson (Yale University, Associate Director of the Yale Depression Research Program) discusses a study looking at the association of electro-convulsive therapy or ECT on all-cause mortality and suicide in Medicare patients with mood and bipolar disorders. Following that, Dr. Ned Kalin, Editor-in-Chief of the Journal discusses the December issue of AJP. Wilkinson interview: Effects of ECT on older patients with mood disorders [00:50] A brief history of ECT [01:20] A troubled history [02:00] A backlash against ECT [02:24] Improved techniques and practices [03:32] Limitations of past research into ECT [04:20] Strength of the study [05:33] How patients were matched [05:59] Limitations of the present study [07:17] Treatment of patients going forward [08:18] Difficulties in administering and accessing ECT [09:49] Next steps in research into ECT and patients with elevated suicide risk [11:14] All-cause mortality and ECT [11:57] Kalin interview: The December issue of AJP [13:02] Major depressive and bipolar disorders [13:13] "Neuromodulation Strategies for the Treatment of Depression" [13:42] "Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients" [14:19] "Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial" [15:29] Ostacher editorial [17:44] "Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies" [18:18] Pariante editorial [20:42] "Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis" [21:23] Putting the issue into context [23:00] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Dr. Jennifer Stevens (Assistant Professor of Psychiatry and Behavioral Sciences, Emory University) discusses a technique to classify trauma victims into discrete biotypes in the immediate aftermath of trauma, with the hope of providing insight into the groups that could guide treatment, and American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin puts the November, 2021 issue of AJP into context. Stevens interview [00:44] Using brain imaging data to understand how people respond to trauma [01:07] Patient enrollment [01:21] AURORA Study [01:42] Can patterns of brain activity help map different responses to trauma? [02:12] Biotypes [02:48] Structure of the study [03:40] Neuroimaging and fMRI tasks [04:11] Limitations [05:44] Biotypes definitions [07:30] Highest risk group [09:10] Most resilient group [09:51] What does this mean for treating trauma patients going forward? [10:17] Next steps [11:31] Kalin interview: looking at trauma and suicide [12:37] Stevens et al. look at neuroimaging and trauma [13:16] Edwards et al. look at genetic and environmental factors in suicide [14:11] McKibben et al. look at suicidal ideation and attempts in U.S. soldiers [16:12] Taken together [18:20] Keding et al. on brain development [19:26] Kumar et al. look at biomarkers and Alzheimer's disease [20:22] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the May 2021 issue. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org

Executive Editor Michael Roy speaks with Lara N. Coughlin, Ph.D., and Lewei Allison Lin, M.D., M.S., about their article on the provision of guideline-concordant depression treatment to patients with and without substance use disorders. Dr. Lara Coughlin is an assistant professor in the Department of Psychiatry and an adjunct assistant professor of psychology at the University of Michigan. She is also a licensed clinical psychologist. Her research aims to find new ways to use behavioral economic frameworks to improve outcomes among individuals with substance use disorders. In particular, she is interested in decision making around health behaviors, such as choosing between sooner and smaller rewards, like substance use, and delayed and larger rewards, like overall health or career development. Her current work looks at the delivery and evaluation of care for underserved and rural populations. Dr. Allison Lin is an addiction psychiatrist, an assistant professor in the Department of Psychiatry at the University of Michigan, and a research scientist in the Department of Veterans Affairs Ann Arbor Healthcare System. How the authors became interested in their areas of research [2:28] How often does depression co-occur with other disorders? [5:05] Current recommendations or best practices for the treatment of these conditions [5:33] Objective of the study [6:55] Description of study participants [7:27] Measures used to collect and analyze data [9:15] Main results of the study [11:20] Were there significant differences between disorders with respect to receipt of appropriate treatment? [12:10] Did any demographic characteristics, medical comorbidities, or other variables affect the findings? [13:25] Other notable or surprising results [14:03] Do the findings of the study extend to patients in the general population? [14:50] Study limitations [15:28] Patient or structural factors that may contribute to inequity in guideline-concordant care [16:13] How can we improve depression care for patients with comorbid substance use disorders? [19:01] Key points that researchers, clinicians, and other mental health professionals should take away from the article [22:12] Recommendations for further research in this area [23:32] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Stitcher, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Watch Deputy Editor Daniel S. Pine, M.D., present highlights from the May 2021 issue. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org