The Peter Attia Drive

In this engaging discussion, various pharmacological tools for boosting metabolic health are explored, including SGLT-2 inhibitors, metformin, and GLP-1 agonists. The potential of SGLT-2 inhibitors as geroprotective agents is closely examined, shedding light on their effects beyond managing blood sugar levels. Additionally, the relationship between statins and insulin resistance is unpacked, discussing the implications for type 2 diabetes risk and overall metabolic health. Strategies for monitoring statin effects and risk reduction are also highlighted.

Harold Burstein, an esteemed breast cancer expert and professor at Harvard Medical School, shares his extensive knowledge on breast cancer. He breaks down the complexities of breast anatomy and discusses various forms of breast cancer, from precancerous lesions to invasive types. Insights into screening methods, including mammograms and MRIs, reveal the ongoing debates about early detection. Burstein also highlights the genetic factors at play, the rarity of male breast cancer, and the importance of personalized treatment plans for improved outcomes.

In this enlightening discussion, Dr. Kari Nadeau, a physician scientist and chair at Harvard's School of Public Health, unpacks the complexities of food allergies. She explains how our immune system, while excellent at fighting pathogens, can mistakenly trigger severe allergic reactions. Dr. Nadeau highlights innovative immunotherapy advancements that can not only alleviate symptoms but potentially cure allergies entirely. She also warns about the rising impacts of air pollution on health and shares practical tips for minimizing exposure.

Delve into the fascinating prospects of living to 120 and the optimistic theories around longevity. Discover Peter's personalized supplement regimen and the complexities of cholesterol management. The discussion emphasizes the importance of individualized nutrition, especially regarding protein intake and maintaining muscle mass. Explore health-tracking wearables and their impact on metabolic health. Together, these insights challenge conventional wisdom and inspire listeners to rethink their approach to health and longevity.

Dive into the world of hormone replacement therapy as the discussion highlights its vital role in women's health during menopause. Discover the signs and symptoms to watch for and learn about FDA-approved HRT options. Explore the challenges of testosterone replacement therapy for women and the essential role of compounding pharmacies. Gain insights on testing for menopause and how hormones like AMH affect fertility awareness. It's an informative session that debunks myths and provides practical guidance for navigating hormone health.

In this engaging discussion, fitness educator Derek, known for his expertise on performance-enhancing drugs via his More Plates, More Dates platform, shares his journey from weightlifting to blending scientific insights with personal experiences. He dives into the complexities of anabolic steroid use, fertility risks, and the long-term effects of growth hormones. Derek also explores the dark side of bodybuilding, including tragic health outcomes and misconceptions around hormone therapies, urging a more informed approach to fitness and performance enhancement.

Ted Schaeffer, an esteemed urologist and author, explores critical issues around prostate health. He discusses natural aging effects, urinary symptoms, and the impacts of medications like finasteride. Schaeffer dives into the complexities of prostate cancer, emphasizing the roles of androgens and genetics in its development. He elaborates on screening methods, including PSA tests and MRIs, and highlights innovative treatment options ranging from surgical interventions to androgen deprivation therapy—all essential insights for proactive prostate health management.

In this engaging discussion, world-leading experts David Sabatini and Matt Kaeberlein dive into the intriguing world of rapamycin, a molecule known for its longevity potential. They share the fascinating history of rapamycin's discovery and its transformation from an immunosuppressant to a geroprotective agent. The conversation addresses crucial questions about its dosing and timing in humans, while examining groundbreaking studies on lifespan extension in mice. Listeners will also learn about the nuances of mTOR's role in aging and the potential implications for future age-related therapies.

Dive into the critical world of metabolic health and its role in chronic diseases like heart issues and cancer. Explore why traditional metrics like BMI fall short and discover better ways to assess health. Learn about various tests and biomarkers, along with actionable tips to boost your metabolic wellness. This discussion demystifies metabolic syndrome, providing insights on how lifestyle changes can make a significant difference to overall health.

Andrew Huberman, a Stanford neurobiology professor and host of the Huberman Lab podcast, joins to discuss groundbreaking research. They dive into metformin's potential as a geroprotective drug and its role in managing type 2 diabetes. The conversation shifts to the power of belief in influencing medication outcomes, distinguishing this 'belief effect' from the placebo effect. Insightful tips on reading scientific papers help listeners navigate complex research, while anecdotes about culture and personal growth enhance the learning experience.