The Peter Attia Drive

Isaac Kohane, a physician-scientist and chair of Biomedical Informatics at Harvard Medical School, shares his insights on the transformative role of AI in medicine. He discusses advancements in disease prediction and early diagnosis, including exciting developments in robotic surgery. Kohane also addresses ethical concerns and the need for responsible integration of AI in healthcare. The conversation highlights the balance between leveraging AI's potential and mitigating risks such as bias and job displacement, making for a thought-provoking exploration of the future of medicine.

Iñigo San-Millán, an internationally renowned applied physiologist, shares insights from his work with elite athletes like Tour de France winner Tadej Pogačar. He discusses the critical role of lactate in exercise performance and how it can indicate metabolic health. San-Millán emphasizes the significance of Zone 2 training for boosting mitochondrial function and longevity, explaining the optimal metrics for this training approach. He also explores the potential of metformin and NAD in enhancing mitochondrial health and the effects of exercise on long COVID recovery.

Discover the fascinating relationship between sun exposure, vitamin D production, and skin health. Dive into the details of different skin types and their unique sun exposure needs. Learn about the complexities of skin cancer, especially melanoma, and the crucial role of early detection. Get practical tips on choosing the right sunscreen, including SPF levels and formulation types. Uncover the often-misunderstood nuances of UV radiation and how to protect your skin effectively against sun damage.

Discover how individuals over 50 can embrace exercise with confidence. The discussion emphasizes that it's never too late to start, addressing common fears around injury and fitness. Learn about the four pillars of exercise essential for older adults and the benefits of resistance training for bone health. The importance of protein in muscle building and practical strategies for safe exercise implementation are also highlighted. Tune in for a blend of insights, encouragement, and humor tailored for those ready to enhance their vitality!

Discover effective strategies to prevent cognitive decline, including the significance of exercise and sleep. Uncover the link between cardiovascular health and Alzheimer's disease, and learn how to lower blood glucose and apoB with dietary changes. Dive into nutrition myths and find tailored dietary approaches for weight loss and longevity. Explore optimal blood pressure management and the benefits of standing versus sitting desks in everyday life. It's a whirlwind of health insights and practical tips for promoting a healthier, sharper mind!

Joel Jamieson, CEO of Morpheus Labs and an expert in conditioning, dives into heart rate variability (HRV) and its significance for fitness and health. He discusses the science behind HRV, how it's measured, and its applications in athletic training. Jamieson highlights the impact of aging, genetics, and lifestyle choices on HRV, along with the advantages of using his innovative Morpheus training tool. Tune in to discover how a deeper understanding of your autonomic nervous system can transform your training regimen and recovery strategies!

Discover key insights on muscle protein synthesis, emphasizing the role of diet and exercise across different populations. Learn about the surprising importance of toe strength in overall health. Delve into the metabolic contrasts between athletes and those with diabetes, and explore the complexities of gut health and the role of probiotics. Peter also shares personal adjustments in his patient care influenced by fascinating discussions, fostering a deeper understanding of health and wellness.

Dena Dubal, a physician-scientist and neurology professor at UCSF, shares her groundbreaking insights on klotho, a longevity protein that promotes brain health and combats cognitive decline. She discusses how factors like stress and exercise influence klotho levels, and presents exciting research showing its potential in treating neurodegenerative diseases, including Alzheimer's. Dena emphasizes the promise of klotho as a therapeutic tool, while highlighting the importance of innovative research and philanthropy in advancing treatments for cognitive health.

Julia Wattacheril, a physician scientist and director of the MASLD program at Columbia University, dives into the critical realm of liver health. She elaborates on the complexities of liver diseases, particularly the impact of alcohol and metabolic dysfunctions. Julia explains liver function tests, the significance of early diagnosis, and how liver health can affect cancer and cardiovascular diseases. She also discusses innovative treatments and the importance of personalized care in managing liver conditions.

Explore the dual nature of inflammation, distinguishing between acute and chronic types, and their ties to aging and health risks. Discover how chronic inflammation links to obesity and metabolic issues. Learn practical strategies to manage inflammation through diet, exercise, and lifestyle choices. Get insights from intriguing studies like the Cantos trial, which investigates inflammation's role in cardiovascular health. Finally, enjoy some humor as cultural references enhance this serious yet entertaining discussion.