The Peter Attia Drive

Dena Dubal, a physician-scientist and neurology professor at UCSF, shares her groundbreaking insights on klotho, a longevity protein that promotes brain health and combats cognitive decline. She discusses how factors like stress and exercise influence klotho levels, and presents exciting research showing its potential in treating neurodegenerative diseases, including Alzheimer's. Dena emphasizes the promise of klotho as a therapeutic tool, while highlighting the importance of innovative research and philanthropy in advancing treatments for cognitive health.

Julia Wattacheril, a physician scientist and director of the MASLD program at Columbia University, dives into the critical realm of liver health. She elaborates on the complexities of liver diseases, particularly the impact of alcohol and metabolic dysfunctions. Julia explains liver function tests, the significance of early diagnosis, and how liver health can affect cancer and cardiovascular diseases. She also discusses innovative treatments and the importance of personalized care in managing liver conditions.

Explore the dual nature of inflammation, distinguishing between acute and chronic types, and their ties to aging and health risks. Discover how chronic inflammation links to obesity and metabolic issues. Learn practical strategies to manage inflammation through diet, exercise, and lifestyle choices. Get insights from intriguing studies like the Cantos trial, which investigates inflammation's role in cardiovascular health. Finally, enjoy some humor as cultural references enhance this serious yet entertaining discussion.

In a special milestone celebration, a variety of health topics take center stage. Geroprotective drugs like rapamycin and metformin are dissected for their potential in longevity. VO2 max and muscle mass emerge as key indicators of health. Blood flow restriction training is introduced for enhanced fitness, while stem cell therapy is scrutinized for its complexities. The nuances of fasting and sugar consumption ignite debate, challenging simplistic views on nutrition. Throughout, personal reflections add richness to the discussion.

Dax Shepard, an actor and passionate car enthusiast, joins to reflect on the 30th anniversary of Ayrton Senna's tragic passing. He shares his deep admiration for Senna, discussing the legend's unique driving style, incredible intuition in automotive engineering, and the emotional connection he established with fans, particularly in Brazil. The conversation dives into the risks of Formula One racing, the advancements in safety since Senna's era, and the lasting legacy he left behind, shaping both motorsport and the hearts of his followers around the world.

Luc van Loon, a leading expert in skeletal muscle metabolism and professor at Maastricht University, delves into the pivotal role of protein in muscle health. He discusses how different protein sources—animal vs. plant—affect muscle protein synthesis and recovery. The conversation explores the significance of protein timing around workouts, the impact of resistance training, and highlights the essential amino acid leucine. Luc emphasizes tailored protein intake for all ages and the nuances of protein digestion, advocating for better nutritional practices to combat muscle loss, especially in aging populations.

Dr. Paul Conti, a psychiatrist and trauma expert from Stanford and Harvard, discusses the critical link between emotional health and overall well-being. He debunks myths around aging and emotional decline, emphasizing proactive self-audits for emotional wellness. Paul highlights the balance between different motivational drives and the impact of negative self-talk. He offers practical strategies for enhancing emotional health and discusses the importance of building strong therapeutic relationships. The conversation also explores embracing life’s uncertainties to foster hope and fulfillment.

Dive into the crucial role of iron in health and the consequences of deficiency. Discover who is most at risk and how to effectively manage iron levels through dietary changes, supplements, and infusions. Learn the nuances of testing for iron, interpreting results, and the significance of ferritin. Additionally, rapid-fire discussions tackle creatine and sodium, keeping the information both relevant and engaging.

Courtney Conley, an internationally renowned foot and gait specialist, dives deep into foot anatomy and the complexity of common injuries like bunions and plantar fasciitis. She emphasizes the significance of proper footwear and the interconnectedness of the kinetic chain impacting overall health. Courtney discusses the benefits of going barefoot, the role of foot strength in preventing injuries, and how mechanics play a vital role in healing. Listeners gain insights on choosing optimal shoes and strategies to enhance foot health and mobility.

Mark Rosekind, a road safety expert with over 30 years of experience, dives into the pressing issue of roadway fatalities. He reveals alarming statistics about accident demographics, particularly among young and older drivers. Discussion topics include the dangers of distractions like smartphone use and the effects of alcohol and sleep deprivation on driving. Rosekind also highlights innovative safety technologies and shares practical advice for enhancing driver and pedestrian safety, emphasizing the need for a proactive approach in reducing risks on the road.