The Peter Attia Drive

Joan Mannick, M.D., co-founder of Restore Bio, and Nir Barzilai, M.D., director at the Institute for Aging Research, delve into the fascinating worlds of rapamycin and metformin. They discuss how these compounds may enhance longevity and boost immune responses, particularly in reducing COVID-19 mortality. Nir shares insights from his clinical trial testing metformin's pro-longevity effects, while Joan explains rapalogs' immune-enhancing capabilities. The potential roles of these drugs in combating neurodegenerative diseases also spark engaging discussions.

Lori Gottlieb, a renowned psychotherapist and author of 'Maybe You Should Talk to Someone,' shares her unique journey from entertainment to therapy. She discusses the profound experience of dissecting cadavers during medical school and the emotional truths revealed through her patients' stories. Lori delves into the complexities of human behavior, particularly in men, and emphasizes the importance of rewriting personal narratives for lasting change. Additionally, she highlights the connection between emotional and physical health, dispelling myths surrounding therapy.

Azra Raza, a leading physician and author, passionately advocates for a paradigm shift in cancer research. She critiques outdated models that hinder progress in survival rates and discusses her book, 'The First Cell.' Highlighting the staggering costs of new cancer drugs, she questions the efficacy of current treatments while pushing for a focus on early detection and prevention. Azra shares her personal journey and the emotional toll of her husband's battle with cancer, ultimately offering an optimistic vision for the future of oncology.

In this discussion, Dom D'Agostino, an expert in ketosis and cancer research, emphasizes the potential of ketogenic diets in reducing cancer therapy toxicity. He talks about the promising applications of hyperbaric oxygen therapy and its therapeutic uses, including possible benefits for COVID-19 patients. Insights on the interplay between glucose and ketones are revealed, alongside the role of vitamin C in enhancing cancer treatment. Additionally, Dom explores how ketosis may impact female health and performance, making a case for its broader applications.

Terry Real, a renowned family therapist and best-selling author, shares insights from his journey shaped by an abusive upbringing. He connects childhood trauma to deep-seated shame and anger, emphasizing the urgent need for emotional healing. Real discusses the transformative power of his Relational Life Therapy, explaining how to confront and break the cycle of pain. He highlights the importance of understanding familial dynamics, empowers emotional vulnerability in men, and challenges patriarchal structures for healthier relationships.

Lloyd Klickstein, Chief Science Officer at resTORbio and a former Novartis and Brigham and Women's Hospital scientist, dives into the fascinating world of aging and how rapamycin could revolutionize longevity. He shares insights from his influential research on mTOR inhibition and its potential to enhance immune function, particularly in older adults. The discussion compares rapamycin’s effects to fasting and its implications for healthspan. With a look at innovative clinical applications, Klickstein highlights the significance of bridging basic science and medicine to tackle age-related health issues.

Stanley Perlman, a seasoned expert in coronaviruses and a professor at the University of Iowa, shares his extensive knowledge on the virus's evolution. He highlights the similarities between SARS-CoV-2 and previous outbreaks like SARS and MERS. The discussion includes insights on durable immunity, long-term effects of COVID-19, and future pandemic preparedness. Perlman also details therapeutic strategies and the role of genetic drift in vaccine efficacy, providing a comprehensive overview of what we've learned and how to better prepare for the future.

Dom D’Agostino, an Associate Professor at the University of South Florida and an expert in ketosis research, discusses the ins and outs of the ketogenic diet. He gives practical tips on optimizing health through training, supplements, and intermittent fasting. The conversation explores how genetic factors influence responses to ketogenic diets and examines the long-term effects on thyroid function. With intriguing insights on measuring ketones and the diet's impact on appetite control, D'Agostino delivers a comprehensive look at this popular health trend.

David Watkins, a pathology professor at George Washington University, dives into the fascinating world of immunology. He explains how lessons from HIV and Zika virus research can enhance our COVID-19 strategies. Monoclonal antibodies come into focus as crucial tools for treatment and vaccine development. Watkins breaks down the roles of B and T cells in the immune response, discussing their importance in combating viral infections. He also emphasizes that vaccines don't need to be perfect to be effective, making science accessible and engaging.

Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute and a leading expert in autophagy, shares her groundbreaking insights on the role of autophagy in health and cancer. She discusses how autophagy can paradoxically help cancer cells survive, revealing new avenues for therapies. Eileen also examines the potential of fasting and specific molecules, like rapamycin and metformin, to enhance autophagy for longevity and disease prevention. The complexity of autophagy’s dual role in cancer growth and protection adds depth to the conversation.