The Peter Attia Drive

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.

27 snips
Oct 26, 2020
Dr. James O’Keefe, a preventative cardiologist and bestselling author, dives into heart health and exercise. He clarifies misconceptions about atherosclerosis, revealing it's not just a plumbing issue. O'Keefe warns about the dangers of excessive exercise and discusses the J-shaped mortality curve. He also explores the impact of nutrients like magnesium and potassium on cardiovascular wellness, the advantages of the Mediterranean diet, and modern medication approaches for diabetes and heart health.
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ANECDOTE

Career Shift

  • James O'Keefe initially specialized in interventional cardiology, using procedures like stents and pacemakers.
  • He transitioned to preventative cardiology after realizing coronary disease is systemic and modifiable.
INSIGHT

Atherosclerosis Analogy

  • Atherosclerosis isn't simply a plumbing problem; it's akin to acne.
  • These "zits" are inflamed pustules that rupture and can cause scarring and calcification in arteries.
ADVICE

Exercise Dosage

  • Exercise is beneficial, but like any drug, the dose matters.
  • Extreme exercise can diminish benefits and potentially harm the heart.
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