The Peter Attia Drive

Layne Norton, Ph.D., a leading expert in nutritional sciences and a renowned physique coach, dives deep into the science of energy balance and its impact on body composition. He explains how tracking calories can be tricky and offers tailored nutrition advice for individuals at different life stages. The conversation highlights the crucial role of protein and resistance training in muscle gain and metabolic health. Layne also discusses effective supplement options like whey protein and creatine, demystifying their benefits for fitness enthusiasts.

Nir Barzilai, M.D., the Director of the Institute for Aging Research at Albert Einstein College of Medicine, shares groundbreaking insights about longevity. He reveals genetic clues from centenarians, discussing how specific gene variants contribute to long lifespans. The conversation explores the TAME trial, emphasizing the potential of metformin as a longevity tool and its varied impacts on health. Barzilai also touches on epigenetic clocks and the controversial role of NAD precursors in aging, inviting listeners to reconsider their understanding of what it means to live a longer, healthier life.

Dive into the silent threat of atherosclerosis, the leading cause of heart disease. Discover how this condition can start early in life and the critical role cholesterol plays in our health. Learn about essential risk factors and the importance of preventive measures to combat this pervasive issue. Explore the significance of diagnostic tests like coronary artery calcium scores and their impact on understanding heart health. Finally, grasp key takeaways for effective prevention strategies against cardiovascular disease.

Join Nick Stenson as he chats with Peter Attia about his evolving views on health and wellness. They delve into advancements in cancer immunotherapy and the importance of aggressive screening for colorectal cancer. Peter discusses the significance of ApoB levels in cardiovascular risk and the role of genetics in Alzheimer’s disease. They also explore the benefits of time-restricted feeding, the complexity of nutrition, and the intriguing connection between psychedelics and mental health. Plus, don't miss a lively discussion on Formula 1 racing strategies!

In a heartfelt remembrance of Sarah Hallberg, a pioneering Medical Director at Virta Health, this conversation dives deep into her groundbreaking work on carbohydrate restriction for treating type 2 diabetes. Sarah challenges conventional dietary beliefs, illuminating the significant role of fatty acids and personalized health strategies. She openly shares her own battle with lung cancer, intertwining her professional insights with poignant personal reflections on resilience, family, and advocating for health equity, all while redefining diabetes management.

Iñigo San-Millán, an internationally renowned applied physiologist, dives into the intricacies of exercise metabolism and health. He shares insights from working with Tour de France champion Tadej Pogačar on lactate levels and fat oxidation. Discover how Zone 2 training enhances mitochondrial function and its implications for longevity. Iñigo explains methods for measuring Zone 2 thresholds, the benefits of incorporating high-intensity training, and discusses mitochondrial health in relation to long COVID and metabolic performance.

This discussion dives deep into hydration, covering water distribution in the body and the vital role of tonicity. Discover the differences between dehydration and volume depletion, and learn how they can impact your health. Explore hydration strategies and when to incorporate electrolytes or glucose. The speaker shares insights on various sports drinks, highlighting the standout options. Personal experiences lead to a renewed focus on hydration's importance for performance and overall well-being.

Ryan Hall, the fastest American marathon and half-marathon runner and author of "Run the Mile You're In," shares insights from his remarkable running journey. He discusses the mental resilience needed to overcome challenges, emphasizing the importance of reframing negative thoughts. Hall reveals training techniques, the benefits of altitude training, and keys to maintaining optimal performance. He also recounts his incredible feat of running seven marathons in seven days as he transitioned from competitive running to coaching, celebrating both success and setbacks.

Dr. Steven Dell, an ophthalmologist and Medical Director of Dell Laser Consultants, shares his expertise in eye health and corrective procedures. He discusses why he chose ophthalmology and covers the anatomy of the eye, age-related vision changes, and common vision loss types. Listeners will learn about innovations like eye drops to improve vision, the rise of myopia in children, and the importance of protecting eye health through outdoor activity. Delving into cataract surgeries and the evolution of laser techniques, he emphasizes the critical need for regular eye screenings.

David Allison, Dean of the Indiana University School of Public Health and a leading obesity researcher, dives deep into the complexities of obesity science. He discusses the origins of the obesity crisis and the pitfalls of nutritional epidemiology. Allison highlights the intriguing 'obesity paradox' and reviews twin studies that shed light on genetic influences. He questions the effectiveness of obesity surgical procedures and emphasizes the importance of rigorous scientific methodologies to rebuild trust in public health data.