Guests Omri Amirav-Dory, Yael Gruenbaum-Cohen, and Peter Nell discuss the importance of strategic partnerships, trust-building, common mistakes in deal-making, commercializing technology as a service, and balancing pipeline advancement in bioplatform business development.

In this conversation, Yogev Debbi, the Founder and CEO of Mana Bio, shares his journey from tech to biotech, emphasizing the untapped potential for tech entrepreneurs in the bio sector. He discusses the transformative impact of CRISPR, the challenges in drug delivery systems, and the importance of automation in biotech. Yogev also highlights building a transparent team culture and bridging the cultural gap between tech and bio to drive innovation. His insights inspire tech founders to embrace the world of biology for creating impactful solutions.

Omri Drory, a general partner focused on network effects in TechBio, lays out a compelling vision for the future. He emphasizes the transformative power of biology as a technology, capable of solving global challenges like disease and climate change. Drory highlights the crucial role of intellectual property and machine learning innovations in this shift from traditional biotech to a dynamic TechBio landscape. He encourages aspiring entrepreneurs to explore this thriving sector and contribute to a brighter tomorrow.

We are in the first wave of web3 games, and some believe that games don't have network effects built into their development or long-term strategy. In this episode, listen to NFX partner Gigi Levy-Weiss as he dives into the world of defensibility within the gaming industry, sharing the 4 layers of network effects, the future of virtual goods, and a case study on Steam - the leading platform for video game development. This is an audio version of episode 10 from The Network Effects Masterclass, curated for audio and listening on the go. For the full video experience, transcripts, and recommended reading, join the free Network Effects Masterclass at - NFX.com/masterclass. (0:00) Introduction to the episode and foundation of NFX (2:38) Understanding network effects in games and misconceptions (3:29) Game liquidity, player matching, and personal networks (5:15) Layers of network effects in games: Game network and personal utility (6:29) The marketplace layer of network effects and the bandwagon effect (8:16) Defensibility and longevity of top games due to network effects (9:39) Introduction to Steam and its marketplace network effect (12:34) User-generated content and virtual goods in Steam's marketplace (14:40) Network effects in Steam, the bandwagon effect, and its 30% rake on transactions (16:50) The challenge for competitors to replicate Steam's network effects (17:13) Concluding remarks and a preview of the next episode

In Web3, network effects are fundamental and critical to survival. If you’re building in Web3 properly, then it should automatically include network effects. Listen in as General Partner Morgan Beller acts like the river guide of network effects for Web3 as she shares her experience and insights on how to be defensible in this new world. Eventually, we will see Web3 swallow Web2 - look how much we’ve learned since that white paper for BTC arrived in 2009. Founders on the frontlines of the Web3 world are educating us on how to remain defensible and retain growth amongst competitors. This is an audio version of episode 9 from The Network Effects Masterclass, curated for audio and listening on the go. For the full video experience, transcripts, and recommended reading, join the free Network Effects Masterclass at - NFX.com/masterclass. (0:00) Introduction to the episode and Morgan Beller (1:26) Overview of Web 3 and its product building path (5:23) Importance of product standard and platform risk in Web 3 (9:10) Applying Web 2 lessons to Web 3 development (11:32) Integrating network effects into your Web 3 business (14:29) The role of tokens in network bonding and social network effects (18:05) Navigating towards the center of the circle for a more defensible position (20:43) Application of Web 3 ethos in the creation of Libra (22:18) The importance of network effects in Web 3's early stage (23:34) Closing remarks and subscription invitation

We're highlighting a breakthrough moment - this summer, Dr. Jacob Hanna, a professor at the Weizmann Institute of Science published a paper demonstrating that synthetic mouse embryos could be grown outside the womb, without an egg or sperm. This is a major advance that was covered by Nature, The Washington Post, The New York Times, and others. Today, the head of NFXBio Omri Amirav-Drory is sitting down with Dr. Hanna to discuss how we reached this milestone, what it means for science, and how entrepreneurship can help bring this technology out of the lab. (0:00) Introduction to synthetic embryos and Dr. Jacob Hanna (4:25) Discussion on growing mouse embryos outside the uterus (7:48) Self-organizing stem cells and their role in synthetic embryos (14:15) Future possibilities and limitations of synthetic embryo development (17:04) Potential treatment of diseases with synthetic embryo technology (20:47) Scientist founder's journey and commercialization of synthetic embryo technology (25:01) Closing remarks and thanks

The podcast dives into the unseen power of network effects in shaping our lives. It reveals how the places we live and the people we associate with influence our decisions, from careers to personal relationships. Listeners learn about the importance of recognizing these dynamics at critical life crossroads. The discussion highlights how merging networks in marriage and selecting cities based on connections can lead to more fulfilling lives. It's a compelling exploration of the interconnectedness that drives our everyday choices.

In this episode, James Currier delves into the power law in network effects and its impact. He explores the transition from an agrarian to a networked economy, discusses the perception of status in this new system, and examines the social and economic impacts of network effect businesses. He also discusses changing social contracts and the role of an ombudsman in network effect businesses. We spend a lot of time teaching Founders how to use network effects to create these giant, world-changing businesses, but we think that too little has been said about how society should adapt to these new network effect behemoths we’re helping create. This episode is hosted by general partner James Currier as he discusses how network effect businesses are reshaping the world, why it's our responsibility to design and thoughtfully set up social contracts with our different constituents, and the need to have a perspective about what you are giving and getting from the people on these networks. This is an audio version of episode 7 from The Network Effects Masterclass, curated for audio and listening on the go. For the full video experience, transcripts, and recommended reading, join the free Network Effects Masterclass at - NFX.com/masterclass. (0:00) Introduction to the episode and network effects (1:12) The power law in network effects and its impact (3:03) Transition from agrarian to networked economy (5:50) Perception of status in the networked economy (7:24) Impact of network effect businesses on society and economy (10:17) Changing social contracts in the networked economy (14:21) Ongoing social contract between businesses and network users - Part II (15:19) Role of an ombudsman in network effect businesses (16:50) Closing remarks and promotion for upcoming episodes

In this episode, Nick Goldner and Jacob Glanville share their founder journeys and discuss platform technologies in biotech. They delve into the business models of Resistance Bio and Sentivax, strategies for infectious diseases, and the challenges of scientific entrepreneurship. The conversation shifts to fundraising experiences and understanding investor feedback, concluding with visions for the future of biotech. In biology we have a saying: what doesn’t kill you mutates and tries again. Cancer. Deadly viruses. These problems are so hard to tackle because the goalposts are always moving. Thanks to evolution, these diseases often outpace therapies and vaccines. Today, NFX General Partner and Head of NFX Bio Omri Amirav-Drory is sitting down with two Founders using platforms to stay a step ahead of evolution. Jacob Glanville, Founder of Centivax, has developed a platform to create broad spectrum vaccines capable of arming the immune system against rapidly mutating viruses (like COVID-19 or influenza). Nick Goldner, Founder of resistanceBio, discusses his approach for mapping all the possible resistance paths a cancer can take in the human body – and developing therapies to shut those escape routes down. Here’s why we need platforms to tackle biology’s biggest problems, what it takes to build a platform company, and their advice for fundraising in Techbio. (0:00) Introduction to the episode and guests (1:45) Founders' journeys: Nick Goldner and Jacob Glanville (8:19) Discussion on platform technologies in biotech (23:30) In-depth look at Resistance Bio and Sentivax's platforms and business models (28:45) Strategies for addressing infectious diseases (34:15) Overcoming challenges in scientific entrepreneurship (34:59) Transition to discussing fundraising experiences (43:42) Understanding the investor's perspective and adapting based on feedback (47:34) Vision for the future of their platforms and the intersection of biology and technology (51:33) Outro and podcast reminders

null These are case studies and stories that outline network effects in the wild - it is a montage of how big tech companies like Trulia, Meta, Uber, and even Bitcoin navigate their defensibility over time. For the best experience of this episode, watch our case studies at nfx.com/masterclass or by searching on YouTube to get the visual side of these deep dives. That was episode 6 of 11, from the Network effects masterclass. Stay tuned and subscribe as next up is Ep. 7 - Network Problems Demand Network Solutions, here on the NFX podcast. This is an audio version of episode 6 from The Network Effects Masterclass, curated for audio and listening on the go. For the full video experience, transcripts, and recommended reading, join the free Network Effects Masterclass at - NFX.com/masterclass.