David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He’s the author of the bestselling book Lifespan: Why We Age—and Why We Don’t Have To, as well as a founder of several biotech companies. Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of common anti-aging practices like interval training, fasting, and stress reduction. David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair 

Matt Kaminski is the Editor in Chief of Politico and the founding editor of Politico Europe. Auren and Matt discuss the challenges of restoring trust in journalism and navigating politics in the digital age. Matt highlights the complicated nuances of getting a story right, the role of bias in journalism, and the need to protect free speech. He also discusses how Politico approached breaking the story of the leaked decision in the Supreme Court’s Dobbs case.  Matt and Auren also explore the evolving landscape of media coverage, and whether or not there’s a conspiracy against Gen X people. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Matt Kaminski on Twitter at @KaminskiMK

Marissa Mayer was the CEO of Yahoo and the 20th employee at Google, where she held key leadership roles in major Google products including Search, Maps, and Gmail. She’s currently the co-founder and CEO of Sunshine. Marissa and Auren discuss the unexpected turn AI has taken towards creativity and expression, and its impact on coding and software engineering. They also explore how AI can improve software engineering and potentially affect the business models of tech giants like Google.Marissa shares insights from her experiences at Google and Yahoo, focusing on bureaucracy and efficiency within tech companies, as well as the origin of Google’s famous APM program and her insights for developing talent. They also talk about Marissa’s startup Sunshine Contacts, building a personal relationship manager, and managing contacts in the age of AI.World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Marissa Mayer on Twitter at @marissamayer.

Tom Tugendhat is the UK’s Minister of State for Security and a British Member of Parliament. He was previously the chairman of the Foreign Affairs Committee in Parliament, and before that he served multiple tours in the British Army in Iraq and Afghanistan. Auren and Tom discuss the role of the UK's Minister of State for Security and Tom’s work with cybersecurity, intelligence gathering, and defense. Tom highlights some of the most overlooked factors in security and what government and private actors should be doing to improve their resilience against cyber threats. Tom and Auren also dive into the changing world of intelligence gathering and open source intelligence (OSINT). They discuss the role of OSINT in understanding the environment and context of situations, how organizations like Bellincat operate, and using OSINT for making predictions. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Tom Tugendhat on Twitter at @TomTugendhat.

Jack Abraham is the founder of Atomic, a startup studio that has launched several dozen companies including Hims & Hers, Openstore, and Bungalow. Before starting Atomic, Jack co-founded Milo, which he sold to eBay.Auren and Jack discuss how the studio fund model works and what’s allowed Atomic to be successful in a space where many other studios have failed. Jack breaks down the process of finding scalable ideas and deciding which ones to allocate resources to. Auren and Jack also dive into the history of the startup studio model and highlight the success stories of companies like Uber, Twitter, and Moderna that originated from studios. They also discuss the benefits of starting a company during a downturn, scaling companies quickly, and the art of branding for both DTC and B2B companies. Jack also shares his thoughts on what’s made Miami a tech hub and where the city will be going in the future.  World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Jack Abraham on Twitter at @jackabraham.

Will Manidis is the CEO and founder of ScienceIO, which builds data solutions for health care. He was previously a managing partner at Dorm Room Fund, and a Thiel Fellow.Auren and Will discuss American dynamism and the future of knowledge work. Will breaks down his view that technology has not improved our lives as much as it should have. He explains how the nature of platform shifts have accelerated tech earnings over the last decade, but kept actual progress low. Will and Auren also do a deep dive on healthcare: why it’s so expensive, why healthcare data is so difficult to work with, and what can be changed. Will emphasizes the need for more usable healthcare data and breaks down how operational workflows consume most of the healthcare dollars spent in the US. They also discuss Will’s practical advice for young founders (as a founder and former Thiel fellow), his early work on classical Greek and Latin, and why everyone should believe in demons.  World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Will Manidis on Twitter at @WillManidis.

Avlok Kohli is the CEO of AngelList and the founder of FastBite and Fairy. Auren and Avlok discuss the underestimated impact of AI and how it could be creating a tech mega cycle. Avlok explains the importance of unique data as a moat for companies building on top of large language models, and how this technology can disrupt incumbents. They also discuss the rise of Dual Threat CEOs and their outsized success in early stage venture capital. Avlok makes the case for why more current operators should start funds, and explains why they’ll thrive in the changing VC landscape. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Avlok Kohli on Twitter at @avlok.

Elad Gil is a prolific angel investor and advisor whose early investments include AirBnb, Coinbase, Pinterest, Stripe, and Square. He’s also the founder of Color Health and author of the bestselling book High Growth Handbook.Elad and Auren discuss the challenges and opportunities for startups in the emerging AI technology landscape, particularly in comparison to incumbent companies. Elad breaks down what he’s learned as an angel investor and provides some non-generic advice for making good early-stage investments. Auren and Elad also discuss fundraising and operating in lean times, the potential for life extension drugs, and why the biotech market is so fragmented. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcasts.You can find Auren Hoffman on Twitter at @auren and Elad Gil on Twitter at @eladgil.

Johnathan Bi is the host of a fantastic seven-part lecture series on the work of philosopher René Girard. He’s also a member of the founding team at Opto Investments. Auren and Johnathan discuss some of the fundamental concepts in Girard’s philosophy and how they apply to startups, venture capital, and life more broadly. They break down physical vs metaphysical desire, the power of self-delusion, and Girard's concept of zero-sum and negative-sum human interactions.Johnathan explains what to make of Girard’s apocalyptic thoughts on the future of humanity, and makes some useful recommendations for using mimetic theory to improve your life. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcastsYou can find Auren Hoffman on Twitter at @auren and Johnathan Bi on Twitter at @JohnathanBi.

Nicole Perlroth was the New York Times’ lead cybersecurity reporter for over a decade. She’s an advisor to the Department of Homeland Security’s Cybersecurity Advisory Committee and the author of the bestselling book This Is How They Tell Me The World Ends.Auren and Nicole discuss the global cyber landscape— which countries have the strongest hacking capabilities, how Ukraine has changed cyber warfare, and where the US stacks up against its adversaries. Nicole also shares insights on personal opsec and recounts her experience tracking down a potential leaker behind the Shadow Brokers hack of the NSA. World of DaaS is brought to you by SafeGraph & Flex Capital. For more episodes, visit safegraph.com/podcastsYou can find Auren Hoffman on Twitter at @auren and Nicole Perlroth on Twitter at @nicoleperlroth.