Count to 10 - Anaesthetic Primary Podcast

In this lively discussion, trainee anaesthetist Nic showcases his exam skills while being evaluated by special guest Celia, an experienced examiner. They delve into essential topics like the components and storage of blood products, the mechanisms of opioids, and the intricacies of thermoregulation. Nic explains how the body senses temperature and compares non-invasive vs invasive blood pressure measurement techniques. The pair wraps up with constructive feedback, highlighting Nic's strengths while identifying areas for improvement, all in a supportive learning atmosphere.

Today's episode is huge!! I go through all the little things not covered in PK or PD with regards to general pharmacology. First, I go through broadly drug preparation and packaging within pharmaceutics (01:18) followed by isomerism (08:11). Then I move on to drug variability starting off with some definitions (19:05) and then moving on to changes in PD and PK among different physiological states (22:47) and pathological states (38:29). Lastly, I look at a classification for adverse drug reactions (44:20). As always, I finish with a look at the past SAQs (48:13). There were so many to go through here! Thanks for listening! As always if you have any feedback let me know

Join the journey of live exam strategy as the host takes on a perusal demo of the 2025.1 Primary paper. Discover a five-step approach to maximize your perusal time, covering essential topics like airway anatomy, respiratory compliance, and fluid distribution. Delve into the cardiovascular effects of sevoflurane, the interaction of NMDA receptors with ketamine, and a comparison of anticoagulants. Conclude with reflections on performance, stressing the impact of exam stress. Tune in for invaluable insights and tips!

Dive deep into pharmacokinetics as key topics unfold! Discover the ADME structure—absorption, distribution, metabolism, and elimination. Learn how different routes of drug administration affect bioavailability and the significance of first-pass metabolism. Explore how compartment modeling aids in understanding drug distribution. Ani also breaks down metabolic reactions and the factors that can modify metabolism. Get insights on half-life concepts and what influences recovery time after infusion. An engaging listen for all pharmacology enthusiasts!

Delve into the fascinating world of pharmacodynamics! Discover how drugs interact with receptors and the mechanisms of action that dictate their effects. Learn about the Law of Mass Action and its role in receptor affinity. Explore the critical dose-effect relationships with illustrative graphs that clarify these concepts. This informative discussion is a must for anyone aiming to grasp the essentials of drug administration in clinical practice.

Dr. Anthony Haidt, an esteemed primary exam examiner and anesthesia specialist, joins to explore the complexities of propofol pharmacokinetics and Target Controlled Infusion (TCI). He breaks down vital equations and utilizes analogies, like a bucket analogy, to clarify rate constants and drug compartment models. The conversation covers age and weight variations in anesthesia dosing, practical applications for clinicians, and the significance of understanding the Marsh and Eleveld models in patient safety. It’s a must-listen for anyone looking to deepen their anesthesia knowledge!

Delve into the fascinating world of immunology and hypersensitivity. Discover how the body defends against infections and the impacts of anesthesia on immune function. Explore the intricacies of hypersensitivity, including anaphylaxis, and learn about the key mediators involved. Get practical insights into treatment strategies like adrenaline dosing and management of refractory cases. Plus, uncover the various types of hypersensitivity reactions and their clinical relevance. An enlightening discussion awaits!

Dive into the fascinating world of cardiac measurement techniques! Discover the ins and outs of non-invasive blood pressure methods, from manual auscultation to automated oscillometry. Learn about the intricacies of invasive arterial lines and the potential sources of error that can affect readings. Explore how transesophageal Doppler and the Fick principle help estimate cardiac output. Plus, wrap up with insights on exam questions tied to blood pressure and cardiac output measurement. Perfect for anyone wanting to enhance their knowledge in cardiac physiology!

Dive into the physiological aftermath of arterial tourniquet release and the surprising mechanisms of hypotension and desaturation. Explore how oliguria emerges in hypovolemic shock, and compare cardiovascular responses to severe blood loss between alert patients and those under anesthesia. Discover the impacts of infusing Hartmann's solution and the nuances of intermittent positive pressure ventilation on cardiac output. Finally, learn about the cardiovascular effects of central neuraxial blocks, CO2 pneumoperitoneum, and how aging and obesity alter heart dynamics.

A lively practice viva covers crucial topics like the immune system and neurophysiology. Celia breaks down innate immunity, discussing physical and chemical barriers, and reflexes that protect the airway. The mechanics of coughing are examined, alongside the effects of general anesthesia on airway defenses. The discussion shifts to intracranial pressure, exploring how age influences it and how positive pressure ventilation interacts with cerebral blood flow. Feedback highlights performance strengths and offers valuable insights for future candidates.