Count to 10 - Anaesthetic Primary Podcast EP33 – Intro to Pharmacokinetics | Anaesthetic Primary Topic | General Pharmacology | CT10
Feb 22, 2025
Dive deep into pharmacokinetics as key topics unfold! Discover the ADME structure—absorption, distribution, metabolism, and elimination. Learn how different routes of drug administration affect bioavailability and the significance of first-pass metabolism. Explore how compartment modeling aids in understanding drug distribution. Ani also breaks down metabolic reactions and the factors that can modify metabolism. Get insights on half-life concepts and what influences recovery time after infusion. An engaging listen for all pharmacology enthusiasts!
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PK Fundamental Building Blocks
- Pharmacokinetics describes what the body does to a drug through absorption, distribution, metabolism and excretion.
- Key building blocks include bioavailability, AUC, extraction ratio, Vd, kinetics, half-life and clearance.
Assess Bioavailability By Route And AUC
- Consider route, local site factors and drug factors to predict absorption and bioavailability.
- Compare AUCs (oral vs IV) to quantify bioavailability for any administration route.
Why Oral Bioavailability Is Often Low
- Oral drugs undergo significant first-pass metabolism in gut mucosa and liver, reducing systemic availability.
- Drug formulation, ionization and pKa strongly determine how much oral dose reaches circulation.