Count to 10 - Anaesthetic Primary Podcast EP32 – Intro to Pharmacodynamics | Anaesthetic Primary Topic | General Pharmacology | CT10
14 snips
Jan 28, 2025 Delve into the fascinating world of pharmacodynamics! Discover how drugs interact with receptors and the mechanisms of action that dictate their effects. Learn about the Law of Mass Action and its role in receptor affinity. Explore the critical dose-effect relationships with illustrative graphs that clarify these concepts. This informative discussion is a must for anyone aiming to grasp the essentials of drug administration in clinical practice.
AI Snips
Chapters
Transcript
Episode notes
Four Mechanisms Of Drug Action
- Pharmacodynamics covers chemical interactions, enzyme action, ion channels and receptors as four distinct mechanisms of drug action.
- Receptors are the largest category but consider all four when asked how a drug works.
Receptor Mechanisms And Speed
- Receptors act by altering ion permeability, producing intermediate messengers, or regulating gene transcription.
- Ion-channel effects are fastest and gene-transcription effects are slowest but longest-lasting.
Memorize Key Second Messenger Systems
- Remember the three major intracellular messenger systems: G proteins, guanylate cyclase, and tyrosine kinases.
- Learn GS, GI and GQ pathways and examples like opioids and adrenaline for exams and practice.