Nourish Balance Thrive

Dr. Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia. In this interview, Dr. Tim talks about methylation, sequencing diet and lifestyle medicine, environmental pollutants, detoxification physiology and treatments plus much more! Here’s the outline of this interview with Dr. Tim Gerstmar, ND: [00:00:23] Methylation: How 1 Carbon Affects Your Brain, Your DNA and Everything — Tim Gerstmar, N.D. (AHS14). [00:04:22] Gut, autoimmune, hard-to-treat cases. [00:05:21] Autism. [00:06:20] Sequencing diet and lifestyle medicine. [00:09:33] Dr. Gerstmar employs health coaches. [00:10:33] 23andMe, penetrance. [00:12:23] Robb Wolf. [00:14:55] Environment toxicity. [00:17:18] Toxicity and thyroid function. [00:18:26] AHS 16 - Tim Gerstmar - Obesogens and Endocrine Disruptors. [00:19:22] 100,000 chemicals into the environment since WWII. [00:19:53] According to the EU, many haven't been adequately safety tested. [00:23:05] Obvious exposure revealed via a detailed history. [00:24:03] Scorecard. [00:24:59] Surviving in a Toxic World: Nonmetal Toxic Chemicals and Their Effects on Health with Dr. Bill Shaw, PhD. [00:25:46] Xylene on the Genova organic acids test (it's also on the Great Plains TOX). [00:30:43] Environmental Working Group Body Burden. [00:32:38] Heavy metals: mercury, arsenic, lead. [00:34:44] Fat soluble compounds. [00:35:16] Nutrient dependencies for detoxification. [00:36:12] Caloric restriction. [00:36:38] Milk thistle. [00:37:03] Sulforaphane Nrf2. [00:37:47] Peeing and pooping. [00:38:33] Sweating and sauna. [00:38:58] Household chemicals. [00:39:19] Flame retardants in clothing. [00:40:18] EWG Dirty dozen and clean fifteen. [00:40:50] Leaner cuts of meat. [00:41:36] Mattresses. [00:42:43] Niacin uses up methyl groups. [00:43:51] Methylation and detoxification. [00:44:37] Sequencing detoxification. [00:45:20] Enterohepatic recirculation. [00:47:31] Evolutionary mismatches. [00:48:08] The gut microbiome, glucuronidation bonds. [00:49:07] Olestra. [00:49:46] Rice bran, psyllium. [00:51:21] Apple pectin. [00:51:45] Aspire Natural Health. [00:53:48] Preconception care for both men and women. [00:56:29] Changing the political climate.

Dr. Dawn Kernagis is a Research Scientist in the area of human performance optimization and risk mitigation for operators in extreme environments, such as those working in undersea diving, high altitude aviation, and space. Dr. Kernagis came to IHMC from Duke University Medical Center, where her postdoctoral research was funded by the Office of Naval Research and the American Heart Association to identify pathophysiological mechanisms and potential therapeutic targets in multiple forms of acute brain injury. Here’s the outline of this interview with Dr. Dawn Kernagis [00:00:20] STEM-Talk podcast. [00:01:35] Ken Ford. [00:03:44] Keto Summit. [00:04:06] Outside Magazine: Is the High-Fat, Low-Carb Ketogenic Diet Right for You? [00:04:22] NEEMO expedition. [00:08:30] The Twins Study was the first study of its kind to compare molecular profiles of identical twin astronauts with one in space and another on Earth. [00:12:04] Apolipoprotein E (APOE). [00:12:13] STEM-Talk Episode 12: Dale Bredesen Discusses The Metabolic Factors Underlying Alzheimer’s Disease. [00:16:28] Apolipoprotein E4 protective against malaria? [00:19:14] AHS 16 - Steven Gundry - Dietary Management of the Apo E4. [00:20:37] STEM-Talk Episode 14: Dominic D'Agostino. [00:21:28] Lauren Petersen: The Athlete Microbiome Project: The Search for the Golden Microbiome. [00:22:55] A combination of 16S, metagenomic shotgun, and metatranscriptomic sequencing. [00:29:48] Estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. [00:31:16] Python, scikit-learn, TensorFlow. [00:31:32] The R Project for Statistical Computing. [00:33:15] MATLAB. [00:34:10] STEM-TALK Episode 1: Peter Attia On How To Live Longer And Better. [00:35:23] Swiss cheese model, Gareth Lock. [00:40:48] Duke University. [00:41:04] Richard Moon. [00:42:59] NEEMO blog.

A Whole Health Educator and Personal Trainer from Mountain View, California asked me some questions about the FDN certification and since we get so many questions like the ones below, Tommy and I did a webinar to answer those and more, live. The questions: What health services did you offer before studying with FDN?  How did you integrate your new training into your service offerings at the beginning? Have you been able to use FDN to build a solid/sustaining income and business model?  If so, how long did that ramp up process take? What marketing initiatives/strategies have you tried?  Which worked best/least? Were there additional/unforeseen start up costs? What challenges have you had along the way to setting up business with FDN?  What might you have done differently? What are your thoughts on the current lab testing that FDN recommends, as well as the supplement brands they have relationships with?   Do you find that most of your income from FDN stems from patient sessions or from supplement income?  Some other avenue? Here’s the outline of this webinar with Dr. Tommy Wood: [00:03:25] Kalish Institute. [00:05:54] Robb Wolf. [00:06:27] Root cause of multiple sclerosis using engineering techniques (paper, talk for the public, talk for physicians). [00:07:16] Tommy's blog. [00:07:53] OAT, DUTCH, blood chemistry. [00:09:09] Chris Kresser's ADAPT course. [00:10:10] Bryan Walsh's Metabolic Fitness Pro biochemistry course. [00:10:28] Khan Academy chemistry. [00:13:31] Mark Sisson's Primal Health Coaching certification. [00:14:59] Functional Diagnostic Nutrition. [00:17:53] Coursera Physiology Course form Duke University. [00:20:01] Why Zebras Don't Get Ulcers. [00:21:34] Jamie Kendall-Weed. [00:24:06] Paleo Physicians Network. [00:26:27] Tommy WOULD do it all again the same :) [00:29:19] "A ticket to play the game"‒Physician's Assistant [00:33:44] Student debt. [00:35:35] How to Start a Startup. [00:36:51] The Elite Performance Program (EPP). [00:37:09] Ralston Consulting. [00:37:49] Lisa Fraley, legal coach. [00:38:08] Client agreements. [00:39:53] Amelia. [00:41:16] Jordan Reasoner podcast. [00:42:33] Practitioner Liberation Project. [00:43:24] Ben Greenfield podcast with Jamie. [00:44:47] Zoom, Zendesk, Slack. [00:45:02] ScheduleOnce. [00:47:04] Trello. [00:48:07] Google Drive [00:48:48] HIPAA compliance. [00:51:24] Data extraction and model building. [00:51:45] Python Machine Learning. [00:52:00] scikit-learn, TensorFlow. [00:52:52] BioHealth Adrenal Stress Profile (saliva). [00:53:17] BioHealth 101. [00:53:53] Mediator Release Test (MRT). [00:54:53] AIP, Whole30. [00:55:13] Cyrex Labs. [00:56:35] Aristo Vojdani. [00:57:00] Ellen Langer. [00:58:01] Align Podcast. [00:58:26] Counterclockwise: Mindful Health and the Power of Possibility. [00:59:10] Ron Rosedale. [01:00:34] Keto Summit. [01:01:04] PHAT FIBRE. [01:03:21] PHAT COW! [01:03:33] Fruition chocolate.

Aaron Alexander is an accomplished manual therapist and movement coach with over a decade of experience. He is the founder of Align Therapy™, an integrated approach to functional movement and self-care that has helped thousands including Olympic and professional level athletes. He is the creator of the 'Self-Care Kit' and the host of a highly ridiculous and informative podcast. Here’s the outline of this interview with Aaron Alexander: [00:00:18] Rolfing Institute. [00:00:28] Structural alignment. [00:01:34] Entrepreneurship. [00:02:10] Align Podcast. [00:02:41] Dr. Stuart McGill. [00:02:50] Bike Fit Done Right: Nigel McHolland on my podcast. [00:02:54] Dr. Ellen Langer. [00:03:59] David Epstein. [00:04:33] Prof. Tim Noakes. [00:04:50] Keto Summit. [00:05:58] Mindfulness. [00:08:42] Hormesis. [00:08:58] Aaron at AHS 16. [00:09:16] Dr. Grace Liu. [00:12:53] Amy Cuddy. [00:15:31] Strongfirst instructor. [00:16:28] Read to Run: Kelly Starrett on my podcast. [00:21:44] Futsal. [00:24:02] Alexander Technique. [00:29:10] Sitting cross-legged. [00:30:09] Pomodoro alarm. [00:30:20] Lotus position. [00:31:47] Esther Gokhale chair. [00:37:26] Aaron is looking for a publisher. [00:40:00] Glidewalking. [00:41:12] Dr. Mark Cucuzzella barefoot running. [00:44:28] Aaron's self-care kit. [00:46:59] Rogue Fitness chinup bar. [00:47:29] My interview on Aaron's podcast.

Lauren Petersen, PhD, is a postdoctoral associate working for Dr. George Weinstock and investigating the microbiome. Our knowledge of the 100 trillion microorganisms that inhabit the human body is still very limited, but the advent of next-generation sequencing technology has allowed researchers to start understanding what kind of microorganisms inhabit the human body and identifying the types of genes these organisms carry. As part of the NIH-funded Human Microbiome Project, her lab is focused on developing and applying the latest technologies to characterize the microbiome and its impact on human health. One of her main projects is metatranscriptomic analysis whereby they are attempting to characterize gene expression of an entire community from human samples such as stool and saliva. Gaining information on what signals or environmental factors can trigger changes in global gene expression of an entire microbial community may provide us with the tools to better treat certain types of diseases in humans. Lauren is currently working on the Athlete Microbiome Project. By collecting stool and saliva samples from a cohort of highly fit professional cyclists, she will make an attempt to understand how their microbiomes may differ from those of the general population. The goal is to characterize the species present, the genes they carry, and how gene expression is modulated in athletes who push their bodies to the limit. Here’s the outline of this interview with Lauren Petersen: [00:00:28] George Weinstock, PhD. [00:01:27] Jeremy Powers interview. [00:01:43] Jeff Kendall-Weed. [00:02:15] Why care about the gut microbiome? [00:03:32] Metabolic functions. [00:03:51] NIH Human Microbiome Project. [00:04:39] Phase II longitudinal study. [00:06:01] Microbial diversity. [00:07:33] Lyme and antibiotics. [00:08:15] Chronic Fatigue Syndrome. [00:09:35] Gordon conferences - Rob Knight. [00:10:27] American Gut Project. [00:10:48] Firmicutes and Bacteroidetes. [00:11:05] Enterobacteriaceae. [00:11:59] Fecal transplant. [00:13:16] Screening donors. [00:13:32] DIY. [00:13:52] C. diff. [00:14:14] Transplants started in the 50s. [00:14:47] IBS. [00:16:12] Healthy donor. [00:17:43] Within a month, Lauren was feeling a lot better. [00:18:13] Instantaneous improvement on the bike. [00:19:22] No more stomach issues, "more energy than I knew what to do with". [00:19:54] Retest data showed perfect match with donor. [00:20:56] Sequencing large vs. small intestinal microbes. [00:21:28] FDA has no idea what to do. [00:23:02] Strategies for maintaining a healthy gut microbiome. [00:23:31] Whole foods, lots of fruit and vegetables. [00:23:48] No gels. [00:24:26] Athlete Microbiome Project. [00:26:34] Microbiome doping? [00:27:05] Ruminococcus - starch digester. [00:28:26] Enterotype - the dominate species in the gut. [00:28:56] Prevotella. [00:30:14] Teasing apart the cause and the effect. [00:32:28] Endotoxins released during intense exercise. [00:32:49] 25 participants at the time of recording, I'm number 26! [00:33:29] Matching cohort of healthy controls. [00:34:28] Ibis World Cup racer. [00:35:01] uBiome. [00:35:08] My app. [00:35:54] The problem with 16S sequencing. [00:36:16] Missing bifidobacteria. [00:37:05] A combination of methods is required for accurate testing. [00:38:30] New commercially available test? [00:39:11] Probiotic quality. [00:40:04] Testing probiotics. [00:41:37] Bifido doesn't like oxygen (or your stomach). [00:42:02] Lactobacillus is more resilient. [00:42:50] Bifido love fructooligosaccharides. [00:43:36] Lack of association with dietary restrictions. [00:44:53] Feed your microbiome!

It's really tough to get science-based information about the ketogenic diet - there's so much new research happening all the time, it's hard to keep up! However, we’ve put together a free online Keto Summit with some world-class doctors, researchers, and athletes who share their latest and best knowledge - how to refine your keto diet, ketone supplements, health benefits of keto, weight loss benefits of keto, and more. I'm especially excited about the talks by Patrick Arnold, Prof. Tim Noakes, and Dr. Kenneth Ford. So, don’t miss out as you can watch them all for free during the event! In fact, if you sign up today, you can watch Dominic D'Agostino’s presentation on Neurodegenerative Diseases, Supplements, & Keto Disease Prevention immediately. Just go here to get your ticket (it starts on Sunday, September 25th).

Joshua Fields Millburn is one half of The Minimalists. At first glance, people might think the point of minimalism is only to get rid of material possessions: Eliminating. Jettisoning. Extracting. Detaching. Decluttering. Paring down. Letting go. But that’s a mistake.  Minimalists don’t focus on having less, less, less; rather, they focus on making room for more: more time, more passion, more experiences, more growth, more contribution, more contentment. More freedom. Clearing the clutter from life’s path helps us make that room. Minimalism is the thing that gets us past the things so we can make room for life’s important things—which actually aren’t things at all. Joshua wasn’t always a minimalist. In late 2009, his mother died and marriage ended (in the same month), and Joshua started questioning everything. That’s when he discovered minimalism. Now, Joshua thinks he owns fewer than 288 things (but he doesn’t actually count his stuff). Minimalism: A Documentary About the Important Things examines the many flavors of minimalism by taking the audience inside the lives of minimalists from all walks of life—families, entrepreneurs, architects, artists, journalists, scientists, and even a former Wall Street broker—all of whom are striving to live a meaningful life with less. Check out the books, “Let go, change your life TEDxFargo talk” and new The Minimalists Podcast, where they discuss living a meaningful life with less stuff and answer questions from their listeners. In the show I mentioned Colin Wright’s Exile Lifestyle blog and Derek Sivers on Tim Ferriss’s podcast.

Any discussion of genetically modified organisms (GMOs) is fraught with difficulty, not least of which is the definition. The Non GMO Project describes them as “organisms whose genetic material has been artificially manipulated in a laboratory through genetic engineering,” but there are others, see Leandra’s AHS 16 poster for more details.           Leandra Brettner is a PhD candidate at the University of Washington department of bioengineering, and in this interview we discuss artificial selection, DNA delivery methods, integration and mutation breeding together with their safety concerns. One might argue that GM is a technique, and that each application should be tested for safety. In this interview I argue to Nassim Nicholas Taleb’s point that GMOs fall into a special class of problem where the potential harm is systemic (rather than localised) and the consequences can involve total irreversible ruin, such as the extinction of human beings or all life on the planet. Here’s the outline of this interview with Leandra Brettner: 0:04:34    Legislation S. 764. 0:08:30    Sequence-specific nucleases. 0:08:49    I went looking for a Khan video on CRISPR Cas9, and found this terrifying TED talk. 0:09:22    Homologous recombination. 0:14:02    Mutation breeding. 0:16:36    Monsanto Buys Seminis (2005). 0:18:41    Leandra misspoke when she said Monsanto owned the BRCA1/2 gene, it was Myriad Genetics. 0:33:32    Bacteriophage. 0:35:54    Evolutionary computation. 0:38:44    The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. 0:40:37    An overview of the last 10 years of genetically engineered crop safety research. 0:43:53    The Precautionary Principle (with Application to the Genetic Modification of Organisms).

This podcast is the second part of a series. In the first part, Dr. Shaw and I talked about how to measure metabolism using organic acids. My initial test showed two major problems: yeast and clostridia overgrowth. It’s been about six months since I took probiotics and Raintree Formulas Amazon antifungals for two months and the retest shows some but not complete improvement. The primary focus of this interview is the new Great Plains test for organic (nonmetal) environmental toxicity, something that I think may be a problem for the people that work with us. I won’t know for sure until we collect some more data, as always I like to test myself before recommending others do the same, and my result turned out to be “one of the cleanest Dr. Shaw has ever seen.” The possible exception is a mild elevation of 2-Hydroxyisobutyric and other metabolites that indicate exposure to petrochemicals I suspect from riding my bike on the road. Download my full result About my guest William Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., he worked for the Centers for Disease Control and Prevention (CDC). Order an organic acids test with nonmetal chemicals profile Use the discount code TOX for $150 off. Here’s the outline of this interview with Dr William Shaw, Ph.D. 0:00:18    Previous interview. 0:03:25    HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid). 0:03:55    D-Lactate free probiotic. 0:04:37    Vancomycin or Metronidazole. 0:05:03    Results, markers 33 and 34. 0:07:00    Arabinose. 0:07:24    Amazon A-F. 0:10:34    The Role of Oxalates in Autism and Chronic Disorders. 0:13:19    How to Protect Your Family from Environmental Toxicity with Dr. Julie Walsh on the Paleo Baby podcast. 0:13:37    AHS16 - Tim Gerstmar - Obesogens and Endocrine Disruptors. 0:16:44    Succinic dehydrogenase. 0:18:20    Tiglylglycine. 0:19:04    Kearns-Sayre syndrome. 0:20:40    2-Hydroxyisobutyric Acid, MTBE and ETBE. 0:43:12    Sauna + niacin flush. 0:50:18    discount code TOX. 0:57:54    GPL webinar archive. 0:58:08    GPL University upcoming events.

Tim JP Collins is a British entrepreneur and host of The Anxiety Podcast. In a former life as an executive, Tim reached a tipping point onstage during a big presentation and has since turned his life around to overcome his anxiety and is now helping other people do the same. Looking back Tim realised that he’d created the perfect storm: Lots of travel away from home and family. Drinking alcohol in excess and too often. Staying up late and then waking up with gallons of coffee. Years of bodily abuse with bad food & not enough exercise. Working in a job that created no meaning. During this interview, you’ll find out how Tim conquered his anxiety. Tim mentioned: Luis Villasenor from Ketogains. The Ultimate Guide To Reinventing Yourself by James Altucher. I mentioned: Minimalism, a Documentary About the Important Things. The Keto Summit. Part two of this conversation is on Tim’s podcast, where I talk about the connection between chronic inflammation and anxiety, and how some of the changes Tim made may have been measurable in blood: Anxiety disorders and inflammation in a large adult cohort Inflammatory markers included C-reactive protein (CRP), interleukin (IL)-6 and tumor-necrosis factor (TNF)-a. Elevated levels of CRP were found in men, but not in women. Interleukin 6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma. (TNF)-a is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. Immune dysregulation is especially found in persons with a late-onset anxiety disorder. Increasing evidence links anxiety to cardiovascular risk factors and diseases such as atherosclerosis, metabolic syndrome, and coronary heart disease. Chronic stress may initiate changes in the hypothalamic–pituitary–adrenal (HPA) axis and the immune system, which in turn can trigger depression as well as anxiety.