Nourish Balance Thrive

Dr Tim Gerstmar practices Naturopathic Medicine at his Redmond, WA office, Aspire Natural Health. He specialises in working with people with digestive and autoimmune problems, and has worked with many of the most difficult to treat situations using a blend of natural and conventional medicine. He treats patients locally, throughout the US and as far away as the Qatar, Korea and Australia. In this interview, Dr Gerstmar discusses the tests he most commonly uses, especially for gastrointestinal complaints. We also talk about strategies for dealing with health insurance and tips for keeping costs down. These scatter plots, sometimes called calibration plots, are the ones I mentioned in the podcast. On the x-axis is what my XGBoost model predicted for previously unseen data, the y-axis represents the measured value. When the dot appears on the diagonal line, the prediction was perfect. The model was trained using results from just 260 athletes. My hope is that is these models will eventually bring down the cost of our full program by allowing us to predict the results of an expensive test using a cheaper one. Here’s the outline of this interview with Dr Tim Gerstmar: [00:00:15] First podcast: Methylation and Environmental Pollutants with Dr. Tim Gerstmar. [00:00:56] Bob McRae podcast: How to Use Biomedical Testing for IRONMAN Performance. [00:01:24] Our Elite Performance Programme. [00:04:04] How much testing should we do? [00:04:35] Factoring in lifetime costs. [00:08:33] Donating blood to the Red Cross. [00:09:44] Iron disorders: ferritin and haemochromatosis. [00:10:53] Therapeutic phlebotomy. [00:14:22] Treating symptoms is sometimes necessary. [00:15:07] Steroids for eczema. [00:17:09] Adrenal dysregulation and thyroid dysfunction. [00:18:00] You can't feel high blood sugar in diabetes. [00:18:46] AIMed conference. [00:19:06] De Fauw, Jeffrey, et al. "Automated analysis of retinal imaging using machine learning techniques for computer vision." F1000Research 5 (2016). [00:20:38] 25-OH-D testing. See Optimizing Vitamin D for Athletic Performance. [00:22:01] Insurance interfering with testing. [00:23:29] Liberty HealthShare. [00:23:42] Affordable Care Act. [00:24:10] Direct Primary Care. [00:24:23] Health Share of Oregon. [00:25:08] Covered California. [00:25:32] Health Savings Account. [00:28:52] Genova GI Effects stool test. [00:29:27] BioHealth stool test. [00:29:49] Doctor's Data stool test. [00:30:13] Coeliac diagnosis. [00:30:50] Transglutaminase. [00:31:44] Genetic risk factors. [00:32:43] NCGS and FODMAPs. [00:34:22] Intestinal lymphoma. [00:37:47] Normal test results are still useful information. [00:38:45] Liver enzymes, e.g. ALT, AST and GGT. [00:39:19] CBC and CMP, Hs-CRP. [00:39:47] Testosterone and thyroid. [00:40:09] Genova SIBO test. [00:41:08] Organic acids by Genova and Great Plains. [00:41:55] Beware insurance with OATs. [00:43:23] Verifying your policy. [00:44:07] Mitochondrial function. [00:44:21] Nutrient deficiencies. [00:44:52] Neurotransmitters and brain function. [00:45:04] Oxidative stress. [00:45:12] Detox stress, GSH status. [00:45:38] Bacterial and yeast markers. [00:46:49] Cortisol testing--DUTCH. [00:48:45] Interview with Pedro Domingos: How to Teach Machines That Can Learn. [00:49:08] XGBoost. [00:50:33] Robb Wolf early adoption costs. [00:51:54] HRV. See Elite HRV podcast. [00:52:08] Supplement companies and self-assessment questionnaires. [00:53:10] Arabinose. [00:53:48] Hallucinating from noise in the data. [00:54:52] Big Data. [00:56:03] Abnormality detection. [00:56:45] Functional versus pathological lab ranges. [00:57:46] Mark Newman. See cortisol testing above. [00:58:23] Adjusted reference ranges. [00:58:45] Vanity sizing. [01:00:52] Thyroid cancer and proximity to a mine. [01:01:21] Aspire Natural Health podcast.

Coach and exercise physiologist Dr Mike T. Nelson pulled me to one side recently after seeing the results of my little experiment with a ketone ester supplement. In this interview, you’ll learn about why Dr. Mike thinks we should exercise caution before regularly simultaneously raising blood glucose and ketones. We also talk about why metabolic flexibility, not ketosis, should be the goal for most endurance athletes. Problems with impaired fat use: From  Nelson, Michael T., George R. Biltz, and Donald R. Dengel. "Repeatability of Respiratory Exchange Ratio Time Series Analysis." The Journal of Strength & Conditioning Research 29.9 (2015): 2550-2558. "Goedecke et al. (12) showed a very large interindividual variability in resting RER from 0.72 up to 0.93 that even persisted during exercise of increasing intensity. This corresponded to a relative rate of fat oxidation that ranged from 23 to 93%. This large interindividual variability in RER from 0.83 to 0.95 was also demonstrated by Helge et al. (16) during low-intensity steady-state exercise. This was quite similar to what we observed with a range of RER from 0.82 to 0.97.” (Nelson, MT, et al. 2015). Goedecke, Julia H., et al. "Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes." American Journal of Physiology-Endocrinology And Metabolism 279.6 (2000): E1325-E1334. Helge, Jørn W., et al. "Interrelationships between muscle fibre type, substrate oxidation and body fat." International journal of obesity 23.9 (1999): 986-991 Problems with impaired carb use: Research has shown that those are on a very low carb diet for prolonged periods of time demonstrate a reduced ability to fully use them during exercise (Burke, LM, et al.; Stellingwerf T. et al). Burke, Louise M., et al. "Effect of fat adaptation and carbohydrate restoration on metabolism and performance during prolonged cycling." Journal of Applied Physiology 89.6 (2000): 2413-2421. Stellingwerff, Trent, et al. "Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration." American Journal of Physiology-Endocrinology and Metabolism 290.2 (2006): E380-E388. Finally, we discuss the potential interference effect of endurance exercise on strength training. Context matters! Only elite athletes probably need to worry about this, and at least one study has shown untrained women can use either order and get similar responses. Here’s the outline of this interview with Mike T. Nelson, PhD: [00:01:02] Keto Summit interview on Metabolic Flexibility. [00:03:25] Complete Blueprint To Faster Results...Without Pain and Plateaus. [00:06:14] Get the "Deadlift Re-alignment for Broken Meatheads." for free. [00:07:28] Online coaching. [00:08:58] http://www.miketnelson.com/podcast [00:09:15] HRV for Successful Online Coaching with Dr. Mike T. Nelson. [00:09:38] ithlete. [00:12:29] Zoom video conference software. [00:13:08] Instant Ketosis: 0.4 to 6.2mM in 30 Minutes. [00:13:47] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet. [00:15:34] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268. [00:16:57] Ketone esters for endurance performance. [00:20:05] Ride time to exhaustion. [00:21:04] Professor Kieran Clarke at Oxford University. [00:22:27] Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More! [00:25:19] Brooks, George A., and Jacques Mercier. "Balance of carbohydrate and lipid utilization during exercise: the" crossover" concept." Journal of applied physiology 76.6 (1994): 2253-2261. [00:26:10] Ketone salts and C8 (caprylic) oil to "push the process". [00:28:05] Fasting and carbohydrate adaptation. [00:28:18] Pyruvate dehydrogenase (PDH). [00:29:39] Ketone supplements and appetite suppression. [00:33:36] Jeff Rothschild. [00:34:20] FATMAX and the hard transition. [00:35:18] Peterson, Benjamin James. Repeated Sprint Ability: The Influence of Aerobic Capacity on Energy Pathway Response and Fatigue of Hockey Players. Diss. UNIVERSITY OF MINNESOTA, 2014. [00:37:42] Reintroducing carbs. [00:41:43] Sprints on wet tarmac (not recommended). [00:43:07] Terzis, Gerasimos, et al. "Early phase interference between low-intensity running and power training in moderately trained females." European journal of applied physiology 116.5 (2016): 1063-1073. Coffey, Vernon G., and John A. Hawley. "Concurrent exercise training: do opposites distract?." The Journal of physiology (2016). Also, 5-10x 2 minute intervals at 120-150% of LT (HIIT) and 15-30 minute continuous cycling at 80-100% of LT equally interfere with the adaptations to resistance training. So it’s not the intensity, more the total volume, that’s the problem. [00:46:22] Prioritising strength in the offseason. [00:48:40] Kiteboarding. [00:49:55] Fortaleza. [00:51:06] Mike's email.

Tommy and I recorded this interview in person at the Buck Institute for Research on Aging where we were attending Dr. Dale Bredesen’s training for reversing cognitive decline. If you’ve yet to discover Dr. Bredesen’s amazing work, I’d highly recommend his STEM-Talk interview. My attempt to capture the impressiveness of the Buck Institute leaves a lot to be desired, but since I promised a photo during the recording, here it is: We love our supplements at Nourish Balance Thrive, and we regularly recommend them to the people we work with, usually when indicated by a test result. What we’re less keen on is expensive nonsense with no human data or even plausible mechanism of action. Oxaloacetate falls into this category, and in this interview, you'll learn enough biochemistry to understand why you should save your money. As always, we reserve the right to be proven wrong! In the second part of this interview, you'll learn about why it's essential to eat to fuel for your activity. We're huge fans of a ketogenic diet for a handful of very specific applications, but not as a general recommendation, especially for athletes engaging in highly glycolytic activities like Crossfit and obstacle course racing. Here’s the outline of this interview with Dr. Tommy Wood, MD PhDc: [00:00:26] Buck Institute for Research on Aging. [00:00:43] Bredesen, Dale E., et al. "Reversal of cognitive decline in Alzheimer's disease." Aging (Albany NY) 8.6 (2016): 1250. [00:00:59] Journal of Neuroscience. [00:02:00] Hippocampal volume increasing. [00:02:26] Blood chem, genotyping, biotoxins, heavy metals. [00:02:32] ReCode software. [00:03:17] Send me your questions for Dr. Bredesen. [00:03:41] Oxaloacetate supplementation. [00:04:01] How to Achieve Near-Normal Blood Sugar with Type 1 Diabetes with Dr. Keith Runyan, MD. [00:05:18] Caloric restriction in humans. [00:05:23] CALERIE trial. [00:06:08] Calorie restriction falters in the long run. [00:07:01] The benefit comes on the refeed. [00:07:14] Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis. [00:07:41] Getting Stronger with Todd Becker. [00:08:18] C. elegans. [00:08:47] Malate-aspartate shuttle. [00:09:20] NAD+/NADH ratio. [00:09:32] AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1). [00:09:45] FOXO3. [00:10:01] Nicotinamide riboside (NR). [00:10:19] Strong, Randy, et al. "Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68.1 (2013): 6-16. [00:11:14] Toxic effects of glutamate. [00:11:48] Excitotoxicity. [00:12:30] Aspartate transaminase (AST) on a blood chem. [00:13:37] The OAA supplements include a meaningless dose anyway. [00:14:17] Anaplerotic reactions. [00:15:27] Pyruvate dehydrogenase and biotin (B7) deficiency. [00:16:54] Context for a ketogenic diet. [00:18:06] Glycolytic activity. [00:19:20] Fasting blood glucose. [00:19:36] Alkaline phosphatase (Alk Phos). [00:20:01] Zinc deficiency. [00:21:26] Thyroid. [00:22:02] Deiodinase enzymes. [00:24:11] Lipids. [00:24:39] LDL receptor. [00:25:29] Red blood cell production [00:25:51] Mean corpuscular volume (MCV). [00:26:33] Macrocytosis due to folate deficiency. [00:29:24] Masharani, U., et al. "Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes." European journal of clinical nutrition 69.8 (2015): 944-948. [00:31:07] Ketosis makes you sharp so you can go get some food. [00:31:46] A New Hope for Brain Tumors with Dr. Adrienne Scheck. [00:31:59] Dominic D'Agostino: Researcher and Athlete on the Benefits of a Ketogenic Diet. [00:32:08] A ketogenic diet shows some promise for Multiple Sclerosis and Alzheimer’s. [00:32:33] Light dark cycles. [00:33:18] Breast feeding and carbs. [00:33:45] Thompson, Betty J., and Stuart Smith. "Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat." Pediatr Res 19.1 (1985): 139-143. [00:34:05] Babies are in ketosis. [00:34:32] Medium-chain triglyceride. [00:35:07] Read, W. W. C., PHYLLIS G. LUTZ, and ANAHID TASHJIAN. "Human Milk Lipids II. The influence of dietary carbohydrates and fat on the fatty acids of mature milk. A study in four ethnic groups." The American journal of clinical nutrition 17.3 (1965): 180-183. [00:35:21] Keto rat experiment.

Hormetism is the application of progressive, intermittent stress to overcome challenges and grow stronger physically, mentally and emotionally. As athletes, we intuitively understand the hormetic effect of exercise but did you know that cold, altitude, plant toxins and even straining slightly to read can all be used to help us get stronger? My guest is for this interview is Todd Becker, a freelance blogger based in the San Francisco Bay Area, where he lives with his wife and two children. He has degrees in Chemical Engineering and Philosophy from Stanford University and Brown University.  Todd currently works as a staff scientist for a biotechnology company in Palo Alto, where he leads project teams and holds more than 20 patents.   Not everyone will have access to all of the hormetic stressors we talk about in this episode. The important takeaway message is that there's more than one way to get stronger. Take advantage in whatever way you see fit. Here’s the outline of this interview with Todd Becker: [00:00:24] Myopia: A Modern Yet Reversible Disease. [00:00:53] AHS16 - Todd Becker - Living High and Healthy. [00:01:48] Hormesis. [00:02:35] Low-carb and intermittent fasting. [00:03:58] Going on holiday and forgetting glasses. [00:04:40] Print pushing. [00:05:02] Exercise. [00:05:29] Immune system. [00:06:07] UV. [00:06:13] Overcompensation. [00:07:28] Lactose tolerance. [00:08:35] Unnecessarily avoiding the sun. [00:10:05] Finding the perfect amount of stress. [00:12:15] Learning to fast blog post. [00:13:00] Heart rate variability or even just resting HR. [00:14:02] Cold showers. [00:14:43] Alcohol. [00:15:53] Metabolic flexibility. [00:16:08] Allostasis. [00:17:07] Wood smoke. [00:17:25] Evolutionary mismatches. [00:17:41] Is charred meat bad for you? [00:18:29] Catching Fire: How Cooking Made Us Human. [00:19:02] Phases of detoxification. [00:19:17] CYP3A4. [00:19:42] Superoxide dismutase. [00:20:01] Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More. [00:21:28] Low-dose dioxins. [00:21:53] Hormone analogues. [00:22:14] Gluten. [00:22:40] IgE emergency response. [00:22:50] An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases. [00:23:36] Peanut allergies [00:23:56] Karelia (historical province of Finland). [00:25:00] Reversing peanut allergies. [00:25:22] Poison ivy and oak. [00:26:49] Peanut oil in diaper cream. [00:27:06] Oral vs topical exposure. [00:27:23] Epstein–Barr virus infection at certain ages. [00:28:09] Altitude. [00:28:24] Boulder has the lowest obesity rate in the US. [00:29:28] PGC1-a via hypoxia. [00:30:16] Barry Murray on my podcast. [00:31:36] Altitude masks. [00:32:02] Train high race low. [00:32:24] Jeremy Powers on this podcast. [00:34:43] gettingstronger.org

Machine learning is fast becoming a part of our lives. From the order in which your search results and news feeds are ordered to the image classifiers and speech recognition features on your smartphone. Machine learning may even have had a hand in choosing your spouse or driving you to work. As with cars, only the mechanics need to understand what happens under the hood, but all drivers need to know how to operate the steering wheel. Listen to this podcast to learn how to interact with machines that can learn, and about the implications for humanity. My guest is Dr. Pedro Domingos, Professor of Computer Science at Washington University. He is the author or co-author of over 200 technical publications in machine learning and data mining, and the author of my new favourite book The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World. Here’s the outline of this interview with Dr. Pedro Domingos, PhD: [00:01:55] Deep Learning. [00:02:21] Machine learning is affecting everyone's lives. [00:03:45] Recommender systems. [00:03:57] Ordering newsfeeds. [00:04:25] Text prediction and speech recognition in smart phones. [00:04:54] Accelerometers. [00:04:54] Selecting job applicants. [00:05:05] Finding a spouse. [00:05:35] OKCupid.com. [00:06:49] Robot scientists. [00:07:08] Artificially-intelligent Robot Scientist ‘Eve’ could boost search for new drugs. [00:08:38] Cancer research. [00:10:27] Central dogma of molecular biology. [00:10:34] DNA microarrays. [00:11:34] Robb Wolf at IHMC: Darwinian Medicine: Maybe there IS something to this evolution thing. [00:12:29] It costs more to find the data than to do the experiment again (ref?) [00:13:11] Making connections people could never make. [00:14:00] Jeremy Howard’s TED talk: The wonderful and terrifying implications of computers that can learn. [00:14:14] Pedro's TED talk: The Quest for the Master Algorithm. [00:15:49] Craig Venter: your immune system on the Internet. [00:16:44] Continuous blood glucose monitoring and Heart Rate Variability. [00:17:41] Our data: DUTCH, OAT, stool, blood. [00:19:21] Supervised and unsupervised learning. [00:20:11] Clustering dimensionality reduction, e.g. PCA and T-SNE. [00:21:44] Sodium to potassium ratio versus cortisol. [00:22:24] Eosinophils. [00:23:17] Clinical trials. [00:24:35] Tetiana Ivanova - How to become a Data Scientist in 6 months a hacker’s approach to career planning. [00:25:02] Deep Learning Book. [00:25:46] Maths as a barrier to entry. [00:27:09] Andrew Ng Coursera Machine Learning course. [00:27:28] Pedro's Data Mining course. [00:27:50] Theano and Keras. [00:28:02] State Farm Distracted Driver Detection Kaggle competition. [00:29:37] Nearest Neighbour algorithm. [00:30:29] Driverless cars. [00:30:41] Is a robot going to take my job? [00:31:29] Jobs will not be lost, they will be transformed [00:33:14] Automate your job yourself! [00:33:27] Centaur chess player. [00:35:32] ML is like driving, you can only learn by doing it. [00:35:52] A Few Useful Things to Know about Machine Learning. [00:37:00] Blood chemistry software. [00:37:30] We are the owners of our data. [00:38:49] Data banks and unions. [00:40:01] The distinction with privacy. [00:40:29] An ethical obligation to share. [00:41:46] Data vulcanisation. [00:42:40] Teaching the machine. [00:43:07] Chrome incognito mode. [00:44:13] Why can't we interact with the algorithm? [00:45:33] New P2 Instance Type for Amazon EC2 – Up to 16 GPUs. [00:46:01] Why now? [00:46:47] Research breakthroughs. [00:47:04] The amount of data. [00:47:13] Hardware. [00:47:31] GPUs, Moore’s law. [00:47:57] Economics. [00:48:32] Google TensorFlow. [00:49:05] Facebook Torch. [00:49:38] Recruiting. [00:50:58] The five tribes of machine learning: evolutionaries, connectionists, Bayesians, analogizers, symbolists. [00:51:55] Grand unified theory of ML. [00:53:40] Decision tree ensembles (Random Forests). [00:53:45] XGBoost. [00:53:54] Weka. [00:54:21] Alchemy: Open Source AI. [00:56:16] Still do a computer science degree. [00:56:54] Minor in probability and statistics.

After a rocky start to the season, NBT client Bob McRae turned everything around using our performance orientated functional medicine program for athletes. "I had the best race of my life yesterday, beyond my imagination." said 47-year old McRae, after his first age-group win (by 14-minutes) and 6th overall at IRONMAN Boulder. Bob is now the number one USAT ranked athlete in his age group.   Listen to this podcast to discover how Bob used a combination of blood chemistry, urinary organic acids and hormone testing, stool culturomics together with diet and lifestyle modification and NSF certified nutritional supplements to achieve peak triathlon performance. Here’s the outline of this interview with Bob McRae: [00:04:22] Dr. Phil Maffetone. [00:09:06] Quest Diagnostics. [00:09:22] Fat Black podcast. [00:11:26] IRONMAN Boulder and Kona. [00:11:47] Bob was unable to elevate his heart rate. [00:13:10] GI symptoms affected racing. [00:13:38] Blastocystis was found on a BioHealth 401H stool test, gone on retest. [00:13:39] Candida overgrowth found on a Great Plains urinary organic acids test. [00:13:47] Elevated lysozyme (an enzyme secreted at the site of inflammation in the GI tract) on Doctor’s Data stool test. [00:13:59] Elevation of white blood cells (eosinophils) on a blood chemistry. [00:15:55] Whole30. [00:16:16] Eliminating sugar, dairy and grains. [00:17:23] Bob has reintroduced sprouted grains. [00:19:03] Bob’s daughter has resolved her skin issues eating the same diet. [00:20:35] Elevated TSH and Thyroid Peroxidase (TPO) Antibodies, both now getting better. [00:22:59] Travelling for triathlon. [00:26:41] Mass start in Kona. [00:26:56] Clif Bar Triathlon Start Commercial. [00:29:44] 1:02 swim. [00:30:15] Working with swim coach and drafting. [00:30:46] Muse meditation device. [00:33:03] EmWave2. [00:33:30] Fat Black podcast #187. [00:33:45] Headspace. [00:34:51] Daniela Ryf. [00:35:57] Andrew Messick CEO of IRONMAN. [00:39:32] First Endurance EFS drink. [00:44:16] Dr. Keith Runyan on my podcast. [00:45:18] 9:45 top 20 in the world. [00:48:14] Elevation of methylmalonic on a urinary organic acids test indicates a deficiency of vitamin B12. [00:48:42] DUTCH. [00:49:18] Iron Rambler blog.

This year in the United States, over 22,000 people will be diagnosed with a primary brain or spinal tumor. Of these, more than 13,000, many of them younger than 21 years old, will die of their disease. New treatment modalities are critical in the battle against cancer. Adrienne Scheck, PhD, is an associate professor of neurobiology at Barrow Neurological Institute. Dr. Scheck’s expertise includes neuro-oncology. She is a member of the American Association for Cancer Research, Society for Neuro-Oncology, American Association for Cancer Research, American Society for Biochemistry and Molecular Biology, Women in Cancer Research, and the American Association for the Advancement of Science. Dr. Scheck’s work consists mainly of translational research to develop novel adjuvant therapies for the treatment of brain tumors. She also use various molecular and molecular genetic techniques to investigate why current therapies sometimes fail.   See Scheck AC[Author] on PubMed. Here’s the outline of this interview with Dr. Adrienne Scheck: [00:00:37] Dr. Jong M Rho. [00:01:18] Glioblastoma. [00:03:53] Hanahan, Douglas, and Robert A. Weinberg. "Hallmarks of cancer: the next generation." cell 144.5 (2011): 646-674. [00:05:01] Cancer metabolism: see Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure. [00:05:37] Positron emission tomography (PET). [00:06:20] Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions. [00:07:21] Adding ketones to a in vitro model. [00:09:14] Poff, Angela M., et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PloS one 8.6 (2013): e65522. [00:11:38] 4:1 KetoCal. [00:13:14] Dr. Cate Shanahan at the Keto Summit. [00:15:05] Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma. [00:17:08] Charlie Foundation and Matthew's Friends. [00:21:42] Clinical trial diet is as close to 4:1 as possible. [00:22:09] Ketogenic Mealplanner – Electronic Ketogenic Manager (EKM). [00:23:01] Cachexia. [00:24:09] Ketones of 3mM, glucose of 4mM. [00:25:59] Adrienne gave a talk in Banff but I couldn’t find it online. [00:26:23] Trial eligibility. [00:30:29] Confounding lifestyle factors. [00:32:58] MRI for tumor metabolism . [00:34:25] Is there something special about brain tumors that makes them particularly susceptible? [00:35:25] Dominic D'Agostino on my podcast and the Keto Summit. [00:35:48] Edema, angiogenesis, and inflammation. [00:37:36] Lussier, Danielle M., et al. "Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet." BMC cancer16.1 (2016): 1. [00:40:14] Gut microbiome. [00:41:50] Ketone supplementation. [00:47:54] Effects in cancer patients may be different from in a healthy person. [00:48:45] Students Supporting Brain Tumor Research. [00:50:35] MaxLove Project. [00:50:47] Donations. [00:52:28] Finding a physician and a dietician. [00:55:13] Education for dietitians and practitioners. [00:57:51] Pluripotency. [00:58:55] Adam Sorenson and father Brad.

Barry Murray is a sports nutritionist and member of the Irish Ultramarathon Team currently working with Pro Tour cyclists. Barry has won several ultra-distance (70-200 km) running races, The Mourne Mountain Way, The Abbots Way, The Giants Causeway, The Wicklow Way, The Kerry Way, all without eating anything for breakfast. How? In a word, fat-adaptation. In this interview, Barry describes his work with the pros and six much overlooked factors for high-performance ultra-endurance training: sunlight, cold thermogenesis, DHA from seafood, grounding, and water quality. Here’s the outline of this interview with Barry Murray: [00:01:56] BMC Racing Team. [00:02:06] Ultramarathon. [00:05:39] Low-carb, high-fat, ketogenic. [00:06:14] Fasted state training. [00:07:16] Sirtuins. [00:12:38] AMP kinase. [00:13:35] Beta-oxidation. [00:13:44] Mitochondrial biogenesis. [00:15:20] Acetyl-CoA. [00:15:38] Peter Attia, MD. [00:16:03] Stepwise adaptation. [00:18:38] What are the pro cyclists doing? [00:19:35] Nutrition is the new doping. [00:23:00] Team Sky. [00:23:55] Steve Cummins. [00:24:29] 2-3 years to adapt. [00:26:00] Can be done in 6-12 months. [00:27:04] Train low, race high. [00:28:26] Rates of brain glucose use. [00:29:30] Pyruvate dehydrogenase. [00:30:34] Ketone MonoEster article. [00:31:21] Are the pros using ketone supplements? [00:32:05] Chris Froome. [00:32:33] Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell Metabolism 24.2 (2016): 256-268. [00:34:00] Beta-oxidation is the goal, not ketogenesis. [00:35:16] Jack Kruse. [00:37:11] Six things to optimal health and living. [00:37:30] Sunlight. [00:37:53] Cold thermogenesis. [00:38:05] Seafood. [00:38:18] Grounding. [00:38:25] Non-fluoridated water. [00:39:55] UVB tanning booths. [00:40:37] Schumann resonance. [00:41:38] Electron Transport Chain (ETC) [00:43:44] Sven Tuft of Orica Bike Exchange. [00:44:45] Wim Hof. [00:45:30] Kox, Matthijs, et al. "Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans." Proceedings of the National Academy of Sciences 111.20 (2014): 7379-7384. [00:48:28] http://optimumnutrition4sport.co.uk/ [00:48:56] Fasted State Training Adaptations Jack Kruse forum post.

Dr. Keith Runyan, MD is a retired physician previously in private practice in St. Petersburg, Florida. Dr. Runyan specialised in internal medicine, nephrology, and obesity medicine. He practiced emergency medicine for ten years before starting his private practice in 2001. In February 2012, he began the diet for the treatment of is diabetes and learned that this diet was also effective for the treatment of numerous other conditions, including obesity. He added obesity medicine to his practice and became board-certified in obesity medicine in December 2012. Dr. Runyan completed an Ironman-distance triathlon on October 20, 2012, in a state of nutritional ketosis and feeling great.   In 1998, he developed type 1 diabetes at the age of 38. Dr. Runyan controlled his diabetes was fairly well with intensive insulin therapy but was plagued with frequent hypoglycaemic episodes. In 2011, while training for an Ironman-distance triathlon, Dr. Runyan was looking for a better way to treat his diabetes and perform endurance exercise, and he decided to give the low-carb, high-fat, ketogenic diet a try.   I’d like to extend special thanks to RD Dikeman and Kory Seder of the TYPEONEGRIT Facebook group for providing me with many of the questions I ask Dr. Runyan during this interview. Here’s the outline of this interview with Dr. Keith Runyan, MD: [00:00:21] Keto Summit all access pass. [00:02:50] Blood sugar 489 mg/dL. [00:04:20] Latent autoimmune diabetes of adults (LADA). [00:05:01] Beta-cell destruction. [00:05:19] Epidemiological: viral infection, oral antibiotics, cow's milk (casein), cereals. [00:07:28] NPH basal insulin (delayed). [00:11:14] Glucagon. [00:13:42] Hypoglycaemic episodes. [00:14:19] Triathlon. [00:16:07] IMTalk Episode 264 - Loren Cordain on the Paleo Diet. [00:17:07] Jimmy Moore podcast. [00:17:22] Robb Wolf. [00:17:32] Dr. Bernstein’s Diabetes Solution. [00:20:52] Continuous glucose monitor. [00:22:34] Keith's blog: Ketogenic Diabetic Athlete. [00:22:50] TYPEONEGRIT Facebook group. [00:23:25] A day in the life of Dr. Runyan. [00:24:37] Consistency is key. [00:25:14] US Wellness Meats Liverwurst. [00:26:28] Humalog insulin, finished in 2.5 hours. [00:27:53] Exercise is key for insulin sensitivity. [00:28:46] Swimming, weightlifting. [00:29:05] Lantin insulin. [00:30:16] Impact of different types of exercise on insulin sensitivity. [00:31:31] Insulin sensitivity follows a circadian rhythm. [00:34:54] Dr. Phil Maffetone. [00:38:09] Powerlifting vs. Olympic lifting. [00:38:31] Greg Everett at Catalyst Athletics. [00:40:12] Carb cravings. [00:41:43] Artificial pancreas. [00:43:24] No more hypoglycaemia in ketosis. [00:44:56] No correlation between blood BHB and symptoms. [00:45:41] The value of lack thereof, of measuring blood BHB. [00:47:30] Glycated proteins in the kidneys. [00:47:50] High-sensitivity C-reactive protein. [00:49:16] Ketosis for type 1 in children. [00:50:09] 1.2g per kg protein. [00:51:38] Vision for spreading the word. [00:52:29] Medicine is an oil tanker. [00:53:54] Dr. Runyan's books for type 1 and type 2. [00:54:50] Ellen Davis of Ketogenic-Diet-Resource.com. [00:55:45] "Normal" blood sugars.

Chris here, writing the show notes for this episode presented by my wife and food scientist Julia Kelly where she interviews Mickey Trescott, and Angie Alt. I’ve talked a lot about ketogenic diets on the podcast, but the truth is ketosis is a hack to improve my cognition and athletic performance. Autoimmune Paleo (AIP) is the diet that enabled me to recover my health, and since then, we’ve coached hundreds of other athletes in our practice using a very similar approach. With the diet cornerstone in place, I became curious about what else I could do to improve my health and athletic performance. Shortly after came my discovery of functional medicine and the hundreds, if not thousands, of other lifestyle factors that needed to be in place in order for me to have what I enjoy today.   The Autoimmune Wellness Handbook addresses the most important of those other lifestyle factors. Authors Mickey and Angie introduce a complementary solution that focuses on seven key steps to recovery: inform, collaborate, nourish, rest, breathe, move, and connect. Here’s the outline of this interview with Julia Kelly, Mickey Trescott, and Angie Alt: [00:01:43] The Paleo Mom. [00:04:26] autoimmune-paleo.com [00:07:22] The athlete's gut. [00:08:46] Inform - be your own expert. [00:09:24] Collaborate - build your team. [00:13:15] Hashimoto's. [00:16:10] Nourish - choosing what to eat. [00:20:17] Movement - should you back off? [00:24:33] Rest. [00:26:37] Breath - managing stress. [00:27:48] Spending time in nature. [00:29:02] Social isolation. [00:34:13] Recipes and meal planning. [00:41:09] The Autoimmune Wellness Handbook: A DIY Guide to Living Well with Chronic Illness. [00:41:16] Autoimmune Paleo podcast.