A New Hope for Brain Tumors

This year in the United States, over 22,000 people will be diagnosed with a primary brain or spinal tumor. Of these, more than 13,000, many of them younger than 21 years old, will die of their disease. New treatment modalities are critical in the battle against cancer.

Adrienne Scheck, PhD, is an associate professor of neurobiology at Barrow Neurological Institute.

Dr. Scheck’s expertise includes neuro-oncology. She is a member of the American Association for Cancer Research, Society for Neuro-Oncology, American Association for Cancer Research, American Society for Biochemistry and Molecular Biology, Women in Cancer Research, and the American Association for the Advancement of Science.

Dr. Scheck’s work consists mainly of translational research to develop novel adjuvant therapies for the treatment of brain tumors. She also use various molecular and molecular genetic techniques to investigate why current therapies sometimes fail.   See Scheck AC[Author] on PubMed. Here’s the outline of this interview with Dr. Adrienne Scheck:

[00:00:37] Dr. Jong M Rho.

[00:01:18] Glioblastoma.

[00:03:53] Hanahan, Douglas, and Robert A. Weinberg. "Hallmarks of cancer: the next generation." cell 144.5 (2011): 646-674.

[00:05:01] Cancer metabolism: see Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure.

[00:05:37] Positron emission tomography (PET).

[00:06:20] Thomas Seyfried: Cancer: A Metabolic Disease With Metabolic Solutions.

[00:07:21] Adding ketones to a in vitro model.

[00:09:14] Poff, Angela M., et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PloS one 8.6 (2013): e65522.

[00:11:38] 4:1 KetoCal.

[00:13:14] Dr. Cate Shanahan at the Keto Summit.

[00:15:05] Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma.

[00:17:08] Charlie Foundation and Matthew's Friends.

[00:21:42] Clinical trial diet is as close to 4:1 as possible.

[00:22:09] Ketogenic Mealplanner – Electronic Ketogenic Manager (EKM).

[00:23:01] Cachexia.

[00:24:09] Ketones of 3mM, glucose of 4mM.

[00:25:59] Adrienne gave a talk in Banff but I couldn’t find it online.

[00:26:23] Trial eligibility.

[00:30:29] Confounding lifestyle factors.

[00:32:58] MRI for tumor metabolism .

[00:34:25] Is there something special about brain tumors that makes them particularly susceptible?

[00:35:25] Dominic D'Agostino on my podcast and the Keto Summit.

[00:35:48] Edema, angiogenesis, and inflammation.

[00:37:36] Lussier, Danielle M., et al. "Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet." BMC cancer16.1 (2016): 1.

[00:40:14] Gut microbiome.

[00:41:50] Ketone supplementation.

[00:47:54] Effects in cancer patients may be different from in a healthy person.

[00:48:45] Students Supporting Brain Tumor Research.

[00:50:35] MaxLove Project.

[00:50:47] Donations.

[00:52:28] Finding a physician and a dietician.

[00:55:13] Education for dietitians and practitioners.

[00:57:51] Pluripotency.

[00:58:55] Adam Sorenson and father Brad.