Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: CHAMPION PHOENIXSpecial Guest: Jack Pluenneke, PharmD, BCCP @JackPluenneke Jack Pluenneke joins to discuss a March 2024 Trial of the Week, “Effect of platelet inhibition with cangrelor during PCI on ischemic events” the CHAMPION PHOENIX trial, published in 2013 in NEJM. We review PK/PD advantages with cangrelor, go over the CHAMPION trials, and then highlight why the CHAMPION PHOENIX trial was necessary. Then we dive into the Trial of the Week: CHAMPION PHOENIX trial and discuss its findings as well as study design. Are these patients we’d see in our ICU? How does cangrelor compare to glycoprotein 2b/3a inhibitors? Is it a weakness that the comparator group uses clopidogrel? The episode closes with medication safety considerations, cangrelor’s place in therapy, and much more. Reference list:  https://pharmacytodose.files.wordpress.com/2024/03/champion-phoenix-trial-of-the-week-references-1.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Corticosteroids in the Critically IllSpecial Guest: Andrea Nei, PharmD, BCPS, BCCCP, FCCM @Dre_pharmd 04:40 – Guideline introduction/background08:35 – Scope/authorship13:35 – PICO questions/recommendations14:22 – Sepsis17:20 – CAP19:10 – ARDS21:55 – Research priorities/Take-home points28:50 – Working with your spouse Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: REDUCESpecial Guest: Matt Duprey, PharmD, PhD, BCCCP Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.” We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode. Reference list:  https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacotherapy in the Critically Ill Pregnant Patient: Part ISpecial Guests: Allison Lankford, MDMelissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin 08:05 – PK/PD changes12:50 – Medication safety/Drug information resources20:15 – Maternal sepsis33:15 – ARDS43:15 – PADIS48:45 – Cardiogenic shock & cardiac arrest59:00 – VTE Pharmacotherapy “Caring for two in the ICU” articles:Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/ PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacist Olivia Morgan discusses the safety and tolerability of rapidly administering undiluted levetiracetam, highlighting findings from a neurocritical care study. The podcast covers changes in administration techniques, protocol updates, administering other anti-seizure medications via rapid IV push, and exploring potential higher doses of levetiracetam.

Pharmacist Traci Grucz discusses ICU hyperglycemia mechanisms, landmark research, current recommendations, tips for hyperglycemia/hypoglycemia, treatment considerations, and key take-home points in managing blood glucose levels in critical care settings.

Literature Review SeriesSeptember 2023Special Guests: Garrett Terhune, PharmDCaroline Blankemeier, PharmD 04:35 – Featured Articles32:28 – Pulm38:35 – PADIS46:50 – Neuro53:40 – Trauma62:00 – PharmD68:10 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2024/02/september-lrs-2023-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

In this podcast, special guest Matt McKenzie, PharmD, BCCCP, discusses various aspects of immunotherapy, including CAR-T cell therapy, cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and immune checkpoint inhibitors. The episode also highlights the complexity of immunotherapy guidelines, challenges in symptom identification, grading scales for CRS and ICANS, adverse effects of HLH in immunotherapy, and the evolving nature of the topic.

Burnout and Well-beingSpecial Guest: Brent Reed, PharmD, MS, PhD Candidate07:25 – How did we get here?09:05 – Defining and drivers of burnout18:45 – Is it too late if we're already experiencing?20:15 – Relationship between well-being and burnout22:00 – Work:life balance29:00 – Precepting and teaching35:25 – Foundation of burnout prevention38:30 – 5 step process for work design change50:50 – Being proactive and short-/long-term fixesReference List: https://pharmacytodose.files.wordpress.com/2024/02/burnout-and-well-being-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesAugust 2023Special Guests: Katie Rogers, PharmDEric Johnston, PharmD04:35 – Featured Articles39:00 – Sepsis47:35 – Potpourri52:45 – Infectious Diseases61:45 – PharmD68:15 – Grab BagReference List: https://pharmacytodose.files.wordpress.com/2024/01/august-lrs-2023-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices