Pharmacy to Dose: The Critical Care Podcast

Ashley McCormick, PharmD, BCPS, BCCCP discusses the ESETT study on anticonvulsant medications for status epilepticus. Topics include ASM PK/PD properties, BZD dosing, seizure cessation rates, dosing scheme origins, medication safety, and more.

Thrombolytic Dosing in PE: Versus SeriesSpecial Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM 05:20 – High-risk PE23:00 – Intermediate-risk37:10 – Cardiac arrest52:30 – Closing arguments57:15 – Bonus: TNK v. tPA Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SEPSISPAMSpecial Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more!  Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacists Judi Jacobi and Michael Sirimaturos discuss glycemic control guidelines in critically ill patients, highlighting the 2024 SECM guidelines, clinical decision support tools, pediatric recommendations, and future research topics. They explore the challenges of updating guidelines, insulin administration strategies, and the importance of pharmacist involvement in multidisciplinary panels for guideline writing.

Literature Review SeriesNovember 2023Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVPBrock Townsend, PharmD @Townsend_PharmD 04:30 – Featured Articles35:25 – Cardiology48:05 – Precision-based medicine potpourri58:50 – Infectious Diseases69:10 – PharmD Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SOAP IISpecial Guest: Jessica Casey, PharmD, BCPS, BCCP @jmc_cardspharmd Jessica Casey joins to discuss the April Trial of the Week “Comparison of Dopamine and Norepinephrine in the Treatment of Shock,” the SOAP II study, published in NEJM in 2010. We set the scene by reviewing catecholamine vasopressor receptor physiology, guideline recommendations, and pre-SOAP II research. Then we do a deep dive into the SOAP II trial of the week. Did including all forms of shock help or hurt? How does the mortality in this study compare with others? Would this have been as positive of a study in 2024? What do the guidelines recommend now? Is dopamine dead? Will anyone take norepinephrine’s throne? Jessica and I review trial fun facts, stand-out supplementary materials, and much, much more.  Reference list: https://pharmacytodose.files.wordpress.com/2024/04/soap-ii-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Salia Farrokh, a clinical pharmacist specialist, discusses landmark studies on nimodipine for aneurysmal subarachnoid hemorrhage in the 1980s. Topics include study methodology evolution, dosing regimens, missed doses, and the relevance of old evidence in current practices.

Norepinephrine Position Paper and Sepsis Research PrioritiesSpecial Guests: Brittany Bissell Turpin, PharmD, PhD, FCCM, BCCCP @BissellBrittanyPatrick Wieruszewski, PharmD, BCCCP @pwieruszSeth Bauer, PharmD, FCCM, FCCP, BCCCP @SethRBauer 07:30 – Norepinephrine position paper introduction11:35 – When did we realize this and what are the implications?36:00 – Key task force take-aways51:00 – SSC Research Committee history56:00 – Submitting and ranking research questions27:00 – Top 5 clinical sepsis research priorities62:00 – Basic science priorities Reference List: https://pharmacytodose.files.wordpress.com/2024/04/norepi-position-paper-and-sepsis-research-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Final Four Preview and More: 2024 Critical Care Trials March Madness Bracket Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCPCV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCPBleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCMNeuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP 06:10 – Region recaps 32:10 – Final Four preview and predictions45:30 – Revisiting pre-tournament predictions PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf  Listener Bracket: https://pharmacytodose.com/2024/04/01/final-four-2024-critical-care-trials-march-madness-bracket-preview-and-recap/  2024 Critical Care Trials March Madness blank bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesOctober 2023Special Guests: Hailey Burns, PharmD @Hailey_rx36Caitlyn Simonson, PharmD 03:45 – Featured Articles38:15 – Neuro50:10 – EM/Tox/Trauma61:50 – Renal/Endocrine66:38 – PharmD70:10 – Sweet Emotion Reference List: https://pharmacytodose.files.wordpress.com/2024/03/october-lrs-2023-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices