Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: Ketamine for EM AgitationSpecial Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd  Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021. We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more.  Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Sanford Guide Q&ASpecial Guest: Doug Black, PharmD 04:40 – Doug’s background/Sanford guide introduction14:20 – Print v. digital guide/included content34:35 – Tables/tools highlights41:55 – Doug’s favorites/conclusions Sanford Guide Website: https://web.sanfordguide.com/ PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacist and critical care specialist, Gabe Fontaine, discusses the history and challenges of ICU bundled care in the context of Code ICH. Topics include BP control, hemostasis, and future directions. The podcast explores time-based metrics in stroke care, anticoagulation reversal, surgical management of intracerebral hemorrhage, and the importance of the Code ICH bundle.

Trial of the Week: MENDS2Special Guest: John Devlin, PharmD, BCCCP, MCCM, FCCP @devlinpharmd 03:20 – PADIS background and research introduction35:25 – MENDS2 discussion John Devlin joins to review the May Trial of the Week “Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis” the MENDS2 study, published in NEJM in 2021.We set the scene by discussing how John developed an interest with PADIS research, discussing PK/PD sedative properties and considerations, landmark trials prior to MENDS2, and how much background work is required for a large RCT.Then we dive into the MENDS2 trial itself. Any significant findings? Biggest methodologic differences from MENDS2 and previous studies? Most challenging process of blinding? Any potential safety concerns? How to avoid unblinding study patients (and why that’s so important)? Plus, trial fun facts, seeing your name in a NEJM research article, applying MENDS2 findings into daily practice, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/mends2-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: ANNEXA-I 02:35 – Study design/results18:30 – Considerations/questions Reference List: https://pharmacytodose.files.wordpress.com/2024/05/annexa-i-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

In this discussion, Jim Miller, a PharmD specializing in critical care, dives into the DESIRE trial, revealing dexmedetomidine's pharmacokinetic advantages and its role in sedation for sepsis patients. He tackles the complexities of changing primary outcomes mid-study and shares insights from his novel research. Meanwhile, Michael Liu, a PharmD with dual board certifications, recounts a gripping in-flight medical emergency he handled, highlighting the unique challenges faced outside a hospital and offering invaluable advice for healthcare professionals in crisis situations.

December 2023 Literature Review SeriesSpecial Guests: Jenna Self, PharmDHannah Millard, PharmD 04:30 – Featured Articles38:45 – Cardiology49:30 – Potpourri53:20 – Sepsis60:00 – PharmD65:00 – Sweet Emotion Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/december-2023-lrs-references.pdfPharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part IISpecial Guest: Snehal Bhatt, PharmD, BCPS, FASHP, AACC @SnayCardsPharmD 04:05 – EMPACT-MI29:35 – ULTIMATE-DAPT Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-ii-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part ISpecial Guest: Ryan Caputo, PharmD, BCCP @RyanCaputo1 04:05 – DanGer Shock29:15 – REDUCE-AMI Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-i-references-1.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacists Christine Groth, Angela Slampak-Cindric, and Kevin Kaucher discuss RSI guidelines, pharmacotherapy, non-pharmacologic recommendations, and potential research ideas. They delve into the importance of evidence-based practices, medication safety concerns, and the impact of guidelines on clinical practice.