Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: ROSESpecial Guest: Christina Rose, PharmD, BCCCP, FCCM @CRosePharmD 05:40 – Pathophysiology/ACURASYS trial 13:45 – ROSE trial discussion38:40 – Current role of NMBA in ARDS Reference list: https://pharmacytodose.com/wp-content/uploads/2024/07/rose-tow-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

HRS-AKI & TerlipressinSpecial Guest: Stephanie Bass, PharmD, FCCP, BCPS, BCCCP 05:45 – HRS and HRS-AKI diagnosis17:00 – Albumin and volume status23:55 – Terlipressin/vasoconstrictor treatment52:00 – Medication safety considerations Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/hrsaki-terlipressin-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: BLING IIISpecial Guest: Jason Roberts, BPharm, PhD, FSHP 05:10 – BLING research background17:30 – BLING III methodology/results53:50 – Practical application/future directions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/bling-iii-rapid-reaction-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ANNEXa-I Deep Dive Part IISpecial Guests: Scott Dietrich, PharmD, BCCCPBrian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCSTodd Miano, PharmD, PhD, FCCM 03:13 – Safety/thrombotic findings21:50 – Questions that remain26:50 – Practical considerations41:40 – P&T elevator pitch Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-ii-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ANNEXa-I Deep Dive Part ISpecial Guests: Scott Dietrich, PharmD, BCCCPBrian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCSTodd Miano, PharmD, PhD, FCCM 05:40 – Brief ANNEXa-I study overview20:40 –Primary composite outcome26:40 – Anti-FXa levels30:45 – Statistics/methodology questions Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-i-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesJanuary 2024Special Guests: Haley Torr, PharmDNick Tran, PharmD 06:55 – Featured Articles32:55 – PAD-IS articles37:10 – Cardiology articles46:00 – Heme articles51:40 – Potpourri articles60:05 – Pharmacist-featured articles67:30 – Sweet Emotion articles Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/jan-2024-lrs-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: PROWESS-SHOCKSpecial Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita 03:30 – Background studies/Setting the scene30:25 – PROWESS-SHOCK discussion/Where are we now Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012. To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions.Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review Series2023 Year-In-ReviewSpecial Guests: Jacquelyn Crawford, PharmD @jacuroniumKathleen Hartman, PharmD @HartKate8 04:30 – Neurology11:05 – Cardiology18:50 – Cardiac Arrest26:30 – Pulmonary35:00 – Sepsis44:05 – Endocrine/Renal52:30 – Trauma61:05 – Infectious Diseases Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Ketamine for EM AgitationSpecial Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd  Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021. We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more.  Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Sanford Guide Q&ASpecial Guest: Doug Black, PharmD 04:40 – Doug’s background/Sanford guide introduction14:20 – Print v. digital guide/included content34:35 – Tables/tools highlights41:55 – Doug’s favorites/conclusions Sanford Guide Website: https://web.sanfordguide.com/ PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices