Trial of the Week: MENDS2Special Guest: John Devlin, PharmD, BCCCP, MCCM, FCCP @devlinpharmd 03:20 – PADIS background and research introduction35:25 – MENDS2 discussion John Devlin joins to review the May Trial of the Week “Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis” the MENDS2 study, published in NEJM in 2021.We set the scene by discussing how John developed an interest with PADIS research, discussing PK/PD sedative properties and considerations, landmark trials prior to MENDS2, and how much background work is required for a large RCT.Then we dive into the MENDS2 trial itself. Any significant findings? Biggest methodologic differences from MENDS2 and previous studies? Most challenging process of blinding? Any potential safety concerns? How to avoid unblinding study patients (and why that’s so important)? Plus, trial fun facts, seeing your name in a NEJM research article, applying MENDS2 findings into daily practice, and so much more. Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/mends2-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: ANNEXA-I 02:35 – Study design/results18:30 – Considerations/questions Reference List: https://pharmacytodose.files.wordpress.com/2024/05/annexa-i-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

In this discussion, Jim Miller, a PharmD specializing in critical care, dives into the DESIRE trial, revealing dexmedetomidine's pharmacokinetic advantages and its role in sedation for sepsis patients. He tackles the complexities of changing primary outcomes mid-study and shares insights from his novel research. Meanwhile, Michael Liu, a PharmD with dual board certifications, recounts a gripping in-flight medical emergency he handled, highlighting the unique challenges faced outside a hospital and offering invaluable advice for healthcare professionals in crisis situations.

December 2023 Literature Review SeriesSpecial Guests: Jenna Self, PharmDHannah Millard, PharmD 04:30 – Featured Articles38:45 – Cardiology49:30 – Potpourri53:20 – Sepsis60:00 – PharmD65:00 – Sweet Emotion Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/december-2023-lrs-references.pdfPharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part IISpecial Guest: Snehal Bhatt, PharmD, BCPS, FASHP, AACC @SnayCardsPharmD 04:05 – EMPACT-MI29:35 – ULTIMATE-DAPT Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-ii-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

ACC 2024 Rapid Reaction: Part ISpecial Guest: Ryan Caputo, PharmD, BCCP @RyanCaputo1 04:05 – DanGer Shock29:15 – REDUCE-AMI Reference List: https://pharmacytodose.files.wordpress.com/2024/05/acc-2024-part-i-references-1.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pharmacists Christine Groth, Angela Slampak-Cindric, and Kevin Kaucher discuss RSI guidelines, pharmacotherapy, non-pharmacologic recommendations, and potential research ideas. They delve into the importance of evidence-based practices, medication safety concerns, and the impact of guidelines on clinical practice.

Ashley McCormick, PharmD, BCPS, BCCCP discusses the ESETT study on anticonvulsant medications for status epilepticus. Topics include ASM PK/PD properties, BZD dosing, seizure cessation rates, dosing scheme origins, medication safety, and more.

Thrombolytic Dosing in PE: Versus SeriesSpecial Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM 05:20 – High-risk PE23:00 – Intermediate-risk37:10 – Cardiac arrest52:30 – Closing arguments57:15 – Bonus: TNK v. tPA Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SEPSISPAMSpecial Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more!  Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices