Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: CRASH-3Special Guest: Ruben Santiago, PharmD, BCPS, BCCCPRuben Santiago joins me to discuss the landmark article “Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients withacute traumatic brain injury (CRASH-3)” published in Lancet.We review the history of TXA use in trauma, what the CRASH-3 study ultimately found, how does this compare to previous studies, what are guideline recommendations, applying this info in the viscoelastic testing era, and much more.Reference list: https://pharmacytodose.files.wordpress.com/2023/10/crash3-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesJuly 2023Special Guests: Chris Bollinger, PharmD, MBAHannah Davis, PharmD04:05 – Featured Articles44:35 – Cardiology60:30 – Hematology65:20 – Pulmonary76:00 – PharmD82:27 – Grab BagReference List: https://pharmacytodose.files.wordpress.com/2023/10/july-lrs-2023-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: UFH v. LMWH for Trauma VTE ProphylaxisSpecial Guest: Brandon Hobbs, PharmD, BCPS, BCCCP, FCCMBrandon Hobbs joins to discuss the landmark article “A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma” published in the New England Journal of Medicine. We review the history of VTE prophylaxis in trauma, what this study ultimately found, how long did it impact practice, what regimen is guideline-recommended today, practices from other centers across the country, and much, more.Reference list: https://pharmacytodose.files.wordpress.com/2023/09/vte-ppx-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Extracorporeal Cardiopulmonary Resuscitation (ECPR) Special Guests: Caitlin Brown, PharmD, BCCCP, FCCMPatrick Wieruszewski, PharmD, BCCCP04:22 – Definition/History of use06:48 – ECPR vs. ACLS11:40 – ECPR research22:00 –VA ECMO overview24:02 – Ideal patients/Contraindications30:52 – ECPR overview from presentation to cannulation41:15 – Pharmacotherapy in longer ECPR cardiac arrests49:00 – ECPR post-resuscitation care50:42 – Guideline recommendations52:50 – Post-cannulation acute complications56:10 – ECMO-induced PK/PD changes59:07 – Advice for new ECPR programs62:20 – Pharmacist’s role/Take-home pointsECPR: A Primer for Pharmacists https://pubmed.ncbi.nlm.nih.gov/37070401/Reference List: https://pharmacytodose.files.wordpress.com/2023/09/ecpr-references.pdfCurious Boxwood Etsy Shop: https://www.etsy.com/shop/curiousboxwoodPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Impact of Pharmacists & MRC-ICU ScoreSpecial Guest: Andrea Sikora, PharmD, MSCR, BCCCP, FCCMAndrea Sikora joins me to discuss her study “Impact of Pharmacists to Improve Patient Care in the Critically Ill: A Large Multicenter Analysis Using Meaningful Metrics with the MRC-ICU Score” published in Critical Care Medicine. We review what the MRC-ICU scoring tool is, evidence up to this point, where it’s been implemented, what did this study show, where do we go from here, how to join the MRC-ICU investigator team, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/09/mrc-icu-tow-references.pdfAndrea’s book: “Pay It Forward: A Map to Mentorship in Medicine”  https://www.amazon.com/Pay-Forward-Map-Mentorship-Medicine/dp/1946665649PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Guest Nick Servati, PharmD, BCCP discusses various topics on Acute Coronary Syndromes (ACS) including pathophysiology and clinical presentation, debunking MONA myths, P2Y12 pretreatment, thrombolytics, anticoagulation, and vasopressors/inotropes. Also covered are IV antiplatelet agents, a STEMI pharmacotherapy checklist, future research and take-home points.

Literature Review SeriesJune 2023Special Guest: Beau Blake, PharmD03:50 – Featured Articles30:40 – Cardiology43:10 – PADIS48:15 – Prostacyclins51:20 – Infectious Diseases 63:10 – PharmD70:15 – Grab BagReference List: https://pharmacytodose.files.wordpress.com/2023/09/june-lrs-2023-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Linezolid v Daptomycin in VRE BSISpecial Guest: Nick Britt, PharmD, MS, BCPS, BCIDPNick Britt joins to highlight his first-author research comparing the use of linezolid v. daptomycin for treatment of vancomycin-resistant Enterococcus bloodstream infection (VRE BSI) published in Clinical Infectious Diseases in 2015. We review what the standard of care was for treatment at this time, how this study became to be, covering this featured article and discussing outcomes/results, then reviewing studies published since, how we still use results from this study, and much, much more.Reference list: https://pharmacytodose.files.wordpress.com/2023/09/dapto-v-linez-vre-bsi-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 Neurocritical Care Society Annual Meeting Pharmacist-featured research02:24 – Multicenter comparison of the safety and efficacy of clopidogrel versus ticagrelor for neuroendovascular stents featuring Casey May, PharmD, BCCCP, FNCS15:24 – Prevalence of augmented renal clearance in neurocritical care population: a prospective multicenter study (Neuro-ARC study) featuring Sherif Mahmoud, BSc (Pharm), MSc, PhD, FNCS24:41 – Derivation and validation of an equation to predict free valproate concentration in intensive care patients featuring Ji Liu, PharmD, BCCCP43:05 – Effect of IV push levetiracetam and lacosamide implementation on turn-around times and cost featuring Veronica Bonderski, PharmD, BCCCP53:25 – Neurostimulant prescription rates in patients with neurologic injuries AND Statin effects on inflammatory biomarker concentrations in patients with mild traumatic brain injury: a potential target for intervention featuring Sulaiman Almohaish, PharmD, BCPS and Gretchen Brophy, PharmD, BCPS, FCCP, FCCM, FNCS, MCCM66:20 – Effect of melatonin on the use of antipsychotic medications in the intensive care unit featuring Madeline Mitchell, PharmD, BCPS77:10 – Pharmacists decrease number of protocol discordant four-factor prothrombin complex concentrate orders for oral anticoagulant-associated intracranial hemorrhage in a community emergency department featuring Ifoma Ofoegbuna, PharmD, BCCCP84:12 – Clinical pharmacist-driven electronic data capture of medication administration records in the ELECTRO-BOOST multicenter study featuring Andy Webb, PharmD, BCCCPLink to research poster PDFs: https://pharmacytodose.com/2023/09/13/2023-ncs-pharmd-research-highlights/PharmacyToDose.Com@PharmacyToDosePharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 Pharmacy to Dose Award Winner Celebration08:04 – Deborah Wagner, Publication of the year winner11:35 – Megan Rech, Mentor of the year winner13:32 – Brian Gilbert, Conference speaker of the year winner15:45 – Melissa Thompson Bastin, Preceptor of the year winner18:14 – Alyssa Meester and Adam Smith, Tag Team Tandem of the year winner21:54 – Grace Erdman, PGY2 resident of the year winner24:45 – Ruben Santiago and Andy Webb, Co-Social media star winners28:17 – Carolyn Bell, People’s Choice award winner30:56 – Mojdeh Heavner, MVP award winner34:06 – Rob Maclaren, Living legend award winner2023 Award Winners: https://pharmacytodose.files.wordpress.com/2023/09/the-2023-pharmacy-to-dose-award-winners.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices