Pharmacy to Dose: The Critical Care Podcast

2023 ACCP Annual MeetingDay 1 & 2 Mini RecapNick discusses his highlights, thoughts, and even suggestions from Day 1 & 2 of the 2023 ACCP Annual Meeting in Dallas, TX.https://www.accp.com/meetings/am23/index.aspx@PharmacyToDosePharmacyToDose@Gmail.ComPharmacyToDose.com Learn more about your ad choices. Visit megaphone.fm/adchoices

AVP: All Vasopressin Podcast features Seth Bauer, a clinical pharmacist in critical care pharmacotherapy, and Gretchen Sacha, a specialist in critical care and vasopressin use. They discuss the historical use and mechanism of action of vasopressin, septic shock guideline recommendations, vasopressin dosing, predicting response, use in special populations, discontinuation, cost considerations, use in other shock states, and future research.

Trial of the Week: Rivers EGDT in SepsisSpecial Guest: Rob Maclaren, PharmD, MPH, MCCM, FCCPI’m joined by Rob Maclaren to discuss the 2001 NEJM study “Early goal-directed therapy in the treatment of severe sepsis and septic shock.”We discuss the historical care of sepsis, mortality rates prior to this study, and use of critical care bundles before highlighting all the findings from the Rivers EGDT in sepsis trial. Then we review if one component is more important than others, break down the bundle, is EGDT still recommended, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/11/rivers-egdt-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 North American Congress of Clinical Toxicology (NACCT)Pharmacist-featured Research Highlights02:36 –  “Association between daily high temperature and copperhead envenomations reported to a regional poison center” ft. Jimmy Leonard, PharmD, DABAT18:22 – “Persistent complications following snake envenomation: results of a specialized snake post-discharge clinic” ft. Erin Ryan, PharmD31:56 – “Evaluation of large-scale, interactive simulation in poison management & drug abuse course” ft. Kristin Reinaker, PharmD, DABAT44:43 – “A systematic review of phenibut withdrawal with a focus on complications, treatment strategies, and phenibut alone or polysubstance withdrawal” ft. Ryan Feldman, PharmD, BCPS, DABAT61:33 – “Evaluation of the carbapenem-valproate interaction” ft. Nick Petrucelli, PharmD70:40 – “The use of ertapenem for reducing toxic valproic acid concentrations” ft. Patrick Dougherty, PharmD, BCPS, BCEMPLink to view research poster PDFs: https://pharmacytodose.com/2023/11/03/2023-nacct-pharmd-research-highlights/@PharmacyToDosePharmacyToDose.comPharmacyToDose@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Linda Awdishu, a clinical pharmacy professor specializing in renal replacement therapy, dives into the critical role of continuous renal replacement therapy (CRRT) in the ICU. She discusses groundbreaking studies like RENAL and IDEAL-ICU, revealing no mortality benefit from higher intensity CRRT and the timing for initiating therapy. Linda emphasizes the necessity for pharmacists to accurately dose antibiotics based on delivered effluent rates. The conversation also explores future research priorities, including AI guidance and improved interdisciplinary collaboration.

Pulmonary Hypertension Part IISpecial Guest: Zach Smith, PharmD, BCPS, BCCCP, FCCP04:03 – Intro/Diagnosis/Classification14:30 – Treatment overview24:00 – CCB30:30 – PDE5i/ERA/GCS40:00 – Prostacyclins 46:40 – RV failure in the ICU64:30 – Role of PharmD/Take-home pointsReference List: https://pharmacytodose.files.wordpress.com/2023/10/pulmonary-hypertension-part-ii-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: AID-ICUSpecial Guest: Grace Erdman, PharmDGrace Erdman, 2023 Pharmacy to Dose Award Winner, joins to discuss “Haloperidol for the treatment of delirium in ICU patients: AID-ICU trial” published in NEJM in 2022.We review studies that led to the AID-ICU study, discuss difficulties with delirium research, deep-dive into the AID-ICU trial, compare treatment in hyper-, and hypoactive delirium, research priorities moving forward, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/10/aid-icu-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SPLITSpecial Guest: Anthony Hawkins, PharmD, FCCM, BCCCPAnthony Hawkins joins me to highlight the “Effect of a Buffered Crystalloid Solution vs. Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial” published in JAMA. We compare the composition of different crystalloids, review pertinent trials published prior to this study, discuss the findings from the SPLIT RCT, what is the best primary outcome in these studies, research on the horizon, questions to be answered, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/10/split-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: CRASH-3Special Guest: Ruben Santiago, PharmD, BCPS, BCCCPRuben Santiago joins me to discuss the landmark article “Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients withacute traumatic brain injury (CRASH-3)” published in Lancet.We review the history of TXA use in trauma, what the CRASH-3 study ultimately found, how does this compare to previous studies, what are guideline recommendations, applying this info in the viscoelastic testing era, and much more.Reference list: https://pharmacytodose.files.wordpress.com/2023/10/crash3-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesJuly 2023Special Guests: Chris Bollinger, PharmD, MBAHannah Davis, PharmD04:05 – Featured Articles44:35 – Cardiology60:30 – Hematology65:20 – Pulmonary76:00 – PharmD82:27 – Grab BagReference List: https://pharmacytodose.files.wordpress.com/2023/10/july-lrs-2023-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices