Pharmacy to Dose: The Critical Care Podcast

Pharmacy to Eat: Food Recommendations and Life Update HAPPY THANKSGIVING!03:19 – Indianapolis: Nick Peters04:50 – Boston: Grace Erdman05:55 – New Haven: Steve Lemieux and Kelly Oldziej08:30 – Buffalo: Nick Servati10:33 – New York: Karen Berger and Peter Nikolos12:58 – Philadelphia: Ashley Barlow, Brooke Barlow, Sara Groome, Alyssa Meester, and Todd Miano19:31 – Maryland: Mojdeh Heavner and Amy Yeung21:38 – Charleston: Melanie Smith Condeni24:07 – Memphis: Morgan Jones26:18 – Cincinnati: Chris Droege30:00 – Chicago: Matt Rubertus31:35 – Detroit: Zach Smith32:57 – Texas: Josiah Smith and Matt Wanat36:25 – Europe: Philip Jacobson 38:12 – Favorite meals: Brian Gilbert and Haley Peters41:02 – Life updatehttps://pharmacytodose.com/2023/11/23/pharmacy-to-eat-food-recommendations/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 ACCP Annual Meeting RecapConference Correspondent: Anthony Hawkins, PharmD, FCCM, BCCCPAnthony’s travel day, Dallas airport comparison and city review, poster hall likes/dislikes, unique and notable clinical sessions, favorite titles, Critical Care PRN business meeting highlights, award winners, FCCP awardees, correcting a last name mispronunciation, #MakePharmacyLessFormal and much more. https://pharmacytodose.com/2023/11/22/2023-accp-annual-meeting-recap/PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 ACCP Annual MeetingDay 1 & 2 Mini RecapNick discusses his highlights, thoughts, and even suggestions from Day 1 & 2 of the 2023 ACCP Annual Meeting in Dallas, TX.https://www.accp.com/meetings/am23/index.aspx@PharmacyToDosePharmacyToDose@Gmail.ComPharmacyToDose.com Learn more about your ad choices. Visit megaphone.fm/adchoices

AVP: All Vasopressin Podcast features Seth Bauer, a clinical pharmacist in critical care pharmacotherapy, and Gretchen Sacha, a specialist in critical care and vasopressin use. They discuss the historical use and mechanism of action of vasopressin, septic shock guideline recommendations, vasopressin dosing, predicting response, use in special populations, discontinuation, cost considerations, use in other shock states, and future research.

Trial of the Week: Rivers EGDT in SepsisSpecial Guest: Rob Maclaren, PharmD, MPH, MCCM, FCCPI’m joined by Rob Maclaren to discuss the 2001 NEJM study “Early goal-directed therapy in the treatment of severe sepsis and septic shock.”We discuss the historical care of sepsis, mortality rates prior to this study, and use of critical care bundles before highlighting all the findings from the Rivers EGDT in sepsis trial. Then we review if one component is more important than others, break down the bundle, is EGDT still recommended, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/11/rivers-egdt-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2023 North American Congress of Clinical Toxicology (NACCT)Pharmacist-featured Research Highlights02:36 –  “Association between daily high temperature and copperhead envenomations reported to a regional poison center” ft. Jimmy Leonard, PharmD, DABAT18:22 – “Persistent complications following snake envenomation: results of a specialized snake post-discharge clinic” ft. Erin Ryan, PharmD31:56 – “Evaluation of large-scale, interactive simulation in poison management & drug abuse course” ft. Kristin Reinaker, PharmD, DABAT44:43 – “A systematic review of phenibut withdrawal with a focus on complications, treatment strategies, and phenibut alone or polysubstance withdrawal” ft. Ryan Feldman, PharmD, BCPS, DABAT61:33 – “Evaluation of the carbapenem-valproate interaction” ft. Nick Petrucelli, PharmD70:40 – “The use of ertapenem for reducing toxic valproic acid concentrations” ft. Patrick Dougherty, PharmD, BCPS, BCEMPLink to view research poster PDFs: https://pharmacytodose.com/2023/11/03/2023-nacct-pharmd-research-highlights/@PharmacyToDosePharmacyToDose.comPharmacyToDose@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

CRRT Trials of the Week: RENAL & IDEAL-ICU Special Guest: Linda Awdishu, PharmD, MASLinda Awdishu joins me to highlight two landmark studies related to the use of continuous renal replacement therapy (CRRT) in the critically ill.We discuss renal replacement therapy, compare modalities, and review the history of CRRT as an introduction. Then we review two studies: “Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients: RENAL study” published in 2009 and “Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis: IDEAL-ICU study” published in 2018, both in the New England Journal of Medicine. Would these findings be replicated in other populations, do we have answers about the most appropriate effluent rate and when to initiate CRRT in the critically ill, findings from both studies, future research priorities, and much, much more!References list: https://pharmacytodose.files.wordpress.com/2023/10/crrt-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Pulmonary Hypertension Part IISpecial Guest: Zach Smith, PharmD, BCPS, BCCCP, FCCP04:03 – Intro/Diagnosis/Classification14:30 – Treatment overview24:00 – CCB30:30 – PDE5i/ERA/GCS40:00 – Prostacyclins 46:40 – RV failure in the ICU64:30 – Role of PharmD/Take-home pointsReference List: https://pharmacytodose.files.wordpress.com/2023/10/pulmonary-hypertension-part-ii-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: AID-ICUSpecial Guest: Grace Erdman, PharmDGrace Erdman, 2023 Pharmacy to Dose Award Winner, joins to discuss “Haloperidol for the treatment of delirium in ICU patients: AID-ICU trial” published in NEJM in 2022.We review studies that led to the AID-ICU study, discuss difficulties with delirium research, deep-dive into the AID-ICU trial, compare treatment in hyper-, and hypoactive delirium, research priorities moving forward, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/10/aid-icu-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: SPLITSpecial Guest: Anthony Hawkins, PharmD, FCCM, BCCCPAnthony Hawkins joins me to highlight the “Effect of a Buffered Crystalloid Solution vs. Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial” published in JAMA. We compare the composition of different crystalloids, review pertinent trials published prior to this study, discuss the findings from the SPLIT RCT, what is the best primary outcome in these studies, research on the horizon, questions to be answered, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/10/split-tow-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices