JAMA Editors' Summary

Discover groundbreaking findings in lung cancer screening that show a program boosting CT scan completion rates. Learn about L‑TromboBag's promising results for treating pediatric ITP, enhancing platelet responses in children. Explore bioresorbable occluders, proving just as effective as metallic ones for ASD closure. Uncover how closed-loop insulin systems improve glucose control for pregnant patients. Plus, insights into healthcare worker challenges and the need for military-civilian partnerships in conflict health delivery.

Discover the intriguing world of microplastics and their potential links to health issues like cardiovascular problems and cognitive decline. Explore the latest findings on blood pressure management during surgeries that showed null effects on outcomes. Dive into innovative stroke treatments involving intra-arterial alteplase that promise improved functionality post-thrombectomy. Plus, engage with the latest discussions around adolescents' social media use and the implications of genetic testing in sports. All this, alongside exciting insights on the role of AI in medicine!

Explore the environmental impact of inhalers as experts discuss greenhouse gas emissions and the push for greener alternatives. Delve into a groundbreaking trial on avalanche survival using innovative devices that could save lives. Discover the surprising statistics on new-onset atrial fibrillation after CABG surgery and its reversibility. Insights on Medicaid spending offer a glimpse into healthcare economics, while conversations around AI caution against cognitive complacency. Each topic weaves a narrative of innovation, survival, and the complexities of modern medicine.

This week, discussions tackle the disappointing results of intratracheal budesonide in treating bronchopulmonary dysplasia. Barriers to accessing cell and gene therapies due to restrictive insurance policies are highlighted. Listeners learn about the risks of Medicaid disenrollment under new work requirements affecting vulnerable populations. The podcast also delves into the implications of moderate alcohol consumption on health and rising early-onset gastrointestinal cancers, underscoring the need for awareness and proactive health measures.

A new trial reveals that levodopa combined with rehabilitation shows no significant motor improvement for stroke survivors. The discussion includes the alarming churn in U.S. child insurance coverage, highlighting the impacts of Medicaid expansion. There's a look at rising payments to AI device manufacturers and concerns about prior authorizations and costs for GLP-1 medications in Medicare. The episode also focuses on teaching critical thinking in medical training, challenges with J-1 visa limits, and tips for effectively communicating risks to patients.

Delve into groundbreaking neonatal platelet transfusion algorithms that could change preterm care. Discover insights from the T‑Mate pediatric heart transplant trial and the complexities of measles case tracking. The discussion also touches on donor-derived EBV risks in kidney transplants. Engaging viewpoints tackle the intersection of research investment and women’s health, plus emerging applications of GLP‑1 treatment. A lively chat about AI safety rounds out the conversation, making this a must-listen for those interested in pediatric medicine.

Delve into the MYPP trial findings on myo-inositol's impact for pregnant individuals with PCOS, revealing it doesn't significantly reduce pregnancy complications. Discover innovative MRI techniques for prostate cancer detection and the advantages of biparametric MRI. Explore pivotal findings enhancing patient care, such as early childhood blood pressure's link to cardiovascular risks. Celebrate the Lasker Awards, spotlighting groundbreaking contributions to medical science, including heartfelt stories of impact. Lastly, get insights on viral infections and obesity treatments from recent JAMA articles.

Recent research reveals the RSV vaccine's effectiveness in reducing hospitalizations among older adults. Vaccination's impact on cardiovascular health is also explored, alongside groundbreaking trials on atrial fibrillation and myocardial infarction. Discussions include gaps in cancer drug trials and the role of AI in medical imaging. Additionally, insights into methamphetamine use disorder are shared, along with promising findings on using LSD for anxiety, and awareness of paternal mental health during the perinatal period is raised.

Gregory Curfman, Executive Editor at JAMA, and Robert O. Bonow, JAMA Cardiology Editor, tackle pressing advancements in cardiac care. They discuss the benefits of remote ECG monitoring for atrial fibrillation detection and the safety of discontinuing anticoagulants post-ablation. The duo also dives into the comparative effectiveness of semaglutide and tirzepatide in heart failure treatment. Lastly, they underscore the significance of bivalent RSV vaccination for older adults, while highlighting the need for greater female representation in cardiovascular trials.

Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from August 23-29, 2025.