JAMA Editors' Summary Microplastics and Health, Perioperative Blood Pressure Management, Intra-Arterial Alteplase for Stroke, and More
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Oct 17, 2025 Discover the intriguing world of microplastics and their potential links to health issues like cardiovascular problems and cognitive decline. Explore the latest findings on blood pressure management during surgeries that showed null effects on outcomes. Dive into innovative stroke treatments involving intra-arterial alteplase that promise improved functionality post-thrombectomy. Plus, engage with the latest discussions around adolescents' social media use and the implications of genetic testing in sports. All this, alongside exciting insights on the role of AI in medicine!
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Individualized MAP Targets Showed No Outcome Benefit
- Individualized perioperative MAP targets based on preoperative nighttime values did not reduce composite adverse postoperative outcomes.
- The IMPROVE multi-trial suggests routine MAP ≥65 mmHg may be as effective as personalized intraoperative targets for these patients.
Preventing Hypotension Didn't Improve Long-Term Function
- A proactive, risk-stratified strategy to prevent intraoperative hypotension did not improve six-month functional disability.
- The PRE-TREAT trial was stopped early for futility, questioning broad adoption of risk-based intraoperative MAP protocols for functional outcomes.
Intra-Arterial Alteplase May Improve Post-Thrombectomy Outcomes
- In the PERL trial, intra-arterial alteplase after successful thrombectomy increased the likelihood of excellent 90-day outcomes.
- The results suggest potential benefit but remain investigational pending further confirmatory evidence.