Gladden Longevity Podcast -- formerly Living Beyond 120

Join Dr. Jeffrey Gladden as he speaks with Michael Brombach, Chief Operating Officer for Recuro Health. He is responsible for driving the strategy and development of Recuro's digital health platform and products, overseeing integration, go-to-market strategy, and future product innovation. The company he founded, SupDoc, an AI-powered health platform for convenient and efficient care services, was acquired by Recuro Health earlier this year to enhance its integrated capabilities. In this episode, they talk about moving from "sick care" to healthcare, from reactive to proactive, creating the first generation of virtual care, and the key elements of a proactive, value-based, accountable care model that can keep people healthier longer and catch things earlier. Listen in to find out what this care model actually is, how it's built, how it works, and how it changes the system. Show notes: Dr. Gladden introduces Recuro Health, SupDoc, and Michael Brombach. (1:10) Micheal talks about his previous experience. (3:30) Michael elaborates on value-based care and accountable care. (6:00) Dr. Gladden mentions how insurance payers and the hospitals may not get what he is trying to do. (9:29) Michael notes how the right tools and the right data could allow physicians to become more efficient and how he left to build SupDoc. (10:00) Michael tells what the most significant thing they do at Recuro is. (10:50) Michael explains how they have a snapshot in time of the whole-person health. (11:50) Dr. Gladden notes that companies invest a lot in training and recruiting, so keeping employees healthy is essential. (13:25) Michael addresses the various concerns when a person is doing something different in healthcare. (15:09) Dr. Gladden asks if these premiums go higher for the employee, go lower for the employee, or start higher and go lower as they stay healthy. (17:00) Michael discusses the key to aligning incentives. Everyone needs to share in both the program's risk and reward. (19:001) Michael tells how the AI is used and how they want to grow it. (21:01) Dr. Gladden shares that he is talking with Michael Gordon and how they are writing a white paper together. (23:45) Michael brings up the different diagnostic tests available in the market at the moment. (25:17) Michael adds that the first significant piece is tailoring testing better, and the second piece is all about what they are doing in behavioral health. (27:07) Dr. Gladden talks about how it would be interesting to see how Recuro moves forward. (29:25) Dr. Gladden emphasizes that democratizing preemptive care versus reactive care is a massive need. (30:46) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about what Michael Brombach is doing in the virtual healthcare world and changing the current system: www.recurohealth.com

Join in on this conversation between Dr. Jeffrey Gladden and Michael Breus, better known as The Sleep Doctor. Breus is a double board-certified Clinical Psychologist and Clinical Sleep Specialist. He is one of only 168 psychologists in the world to have taken and passed the Sleep Medicine Boards without going to Medical School. He is an expert resource for most major publications doing more than 400 interviews per year. This episode touches on energy, movement, body types, chronotypes, sleep, diet, relationships, and sex. Yes, The Sleep Doctor can teach you how to optimize all these areas and give you a hint about how best to organize your days according to your sleeping patterns and needs. If you want to revolutionize your entire life just by identifying your sleep chronotype and making a few adjustments in your benefit, this episode is for you. Show notes: Dr. Gladden introduces Michael Breus. (00:57) Breus mentions how he is known as the sleep doctor and chronotype guy. (3:25) Dr. Gladden asks Breus if genetics determine or set people's circadian rhythms. (5:31) Breus explains what happened when he allowed himself to sleep at midnight and wake up naturally. (7:11) Breus brings up the power and importance of WHEN you go to sleep. (9:00) Breus explains that if you do something at a time when your body wants to do it, then your body will do it better. (10:10) Breus shares that waking on his own naturally makes his morning better. (11:35) Breus tells us that sleep in itself is very dehydrating. (13:00) Breus talks about having the right routines and how his morning routines click him in and allow him to go the places he wants to go. (15:25) Dr. Gladden hints that, according to a universal finding, if people take too much to drink, they don't sleep well at all. (16:55) Dr. Gladden says the best thing that you can give to somebody is to understand them better. (19:15) Breus speaks about how he does four ten-minute meditations every morning. (20:25) Breus mentions that "Bears" make up fifty percent of the population. (23:29) Breus explains how he wrote his books for insomniacs/dolphins and how their sleep drive is very short. (25:23) Breus talks about how there is genetic insomnia and learned insomnia. He also notes that people go through all the chronotypes as they grow from childhood to adulthood. (26:16) Breus elaborates about the quality and amounts of sleep of infants versus teenagers. Infants sleep for physical development while teenagers sleep for emotional development. (28:30) Breus mentions the importance of knowing your bedtime based on your chronotype and doing what helps you relax. (31:17) Breus goes through the areas that are important when it comes to blocking the blue light. He says you need some for frequency, brightness, and angle. (33:45) Dr. Gladden makes the point that you can never think yourself back to sleep. (35:25) Breus adds that sleep is a lot like love. The more you look for it, the less you find it. (37:00) Breus brings up that many people don't breathe deeply and are shallow breathers. (39:38) Dr. Gladden points out that breathing your way back to sleep as opposed to thinking your way back to sleep is the best option. (41:23) Dr. Gladden mentions that anxiety is a function of not feeling safe. (43:30) Breus clarifies that on, a general level, most people can sleep. (45:37) Breus comments on oxytocin and also on the best time to have sex. (48:25) Breus says to couples that there is a perfect time for sex, and partners should find a way to figure it out. (50:40) Breus gives a five-step plan. Wake up at the same time seven days a week, stop caffeine at 2 pm and stop alcohol three hours before bed. It is also essential to stop exercise four hours before bed and have a morning routine of taking fifteen deep breaths, drinking fifteen ounces of water, and getting fifteen minutes of sunshine. (53:38) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevity / @jeffgladden_md Twitter: @gladdenlongevit / @jeffgladden_md Facebook: @GladdenLongevity For more information on our practice and becoming a client: www.gladdenlongevity.com To learn more about The Sleep Doctor, visit his website and social media: Website: www.thesleepdoctor.com Facebook: @TheSleepDoctor Instagram: @thesleepdoctor Twitter: @thesleepdoctor YouTube: @TheSleepDoctor-MichaelBreus And to find out what your sleep chronotype is: Take the chronotype quiz!

Join Dr. Jeffrey Gladden in this interesting conversation with Mark Young Jr., With a resumé steeped in business startups and entrepreneurial ventures, Mark Young joined the Zona Health team in 2016 with a single purpose: to make the Zona Plus a household name. To say that Young's background is diverse would be an understatement, but "one consistent thread ties it all together," he would say, "and that is a passion for education … delivering practical solutions in a way that invites people in." And at Zona Health, education is the key to engagement. As the episode progresses, they talk about how Zona Plus increases nitric oxide, what isometric exercises have to do with longevity and blood pressure, and nitric oxide's influence on metabolic and cardiovascular function. Dr. Gladden welcomes Mark Young Jr. to the show. (2:20) Mark shares how he took a leadership position in Zona and mentions Dr. Gladden's love for biohacking. (4:10) Mark mentions what Dr. Wiley noticed while studying to know more about fighter pilots' reactions to high speeds. (6:49) Mark elaborates on how Dr. Wiley made the connection that isometrics improves cardiovascular health and specifically lowers blood pressure in that respect. (8:30) Mark tells how Zona calibrates to your current maximum voluntary contraction. (10:51) Dr. Gladden poses the question: Is there a problem if one squeezes the device harder than usual? (11:58) Dr. Gladden talks about how they measure grip metrics. (14:03) Mark notes that using Zona is just like doing a plank: everyone finds it easy at first, but it begins to look/feel difficult after a few minutes if they have not been doing it regularly. (16:00) Mark clarifies that there are signals on the Zona screen to help keep you in a particular range because it's too hard for anybody to stay at exactly the same pressure for two minutes. (18:35) Mark points out that nitric oxide flow reduces blood pressure by opening the cardiovascular system and that nitric oxide typically stays in the body for approximately six hours before it starts diminishing. (20:06) Mark highlights that an equal balance of sodium and potassium must exist in every cell at all times. (22:07) Dr. Gladden mentions how arteriosclerosis actually has to do with an increase in senescent cells inside the arterial wall, leading to that excess thickening, and then it's also complicated and stiffening by the destruction of something called the glycocalyx. (24:05) Dr. Gladden adds how over time, there is increased oxidative stress on the arterial wall. (26:00) Mark makes the statement that potassium is your longevity doctor. (28:00) Mark points out that using the Zona Plus, they have noticed that the higher the blood pressure, the better the drop. They also noticed approximately a 15% drop in systolic and up to a 10% drop in diastolic. (30:30) Mark adds that Zona increases blood flow, which obviously can reverse erectile dysfunction or eliminate that symptom. (32:39) Mark tells us how he uses nitric boost pre-workout to improve blood flow and energy. (34:24) Marke shares how he used Zona to deal with a blood pressure issue he had. (36:27) Dr. Gladden cautions that those with high blood pressure who want to try out the Zona should not stop taking their medication suddenly. (38:50) Mark advices monitoring your blood pressure frequently, so it does not become too low. (41:00) Mark explains how using Zona is a way to make your body do what your body was made to do. (44:19) Mark describes how we only have a sick care system instead of a health care system. (47:30) Dr. Gladden brings up how tragic it is when the sexual function is sacrificed or feels the need to be sacrificed for the sake of another health problem. (51:15) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevity / @jeffgladden_md Twitter: @gladdenlongevit / @jeffgladden_md Facebook: @GladdenLongevity For more information on our practice and becoming a client: www.gladdenlongevity.com Get more info on the Zona Plus too! Website: www.zona.com Call: (800) 252-3810 Text: 754-732-9662 Email: customerservice@zona.com Facebook: @ZonaHealth Instagram: @zonahealth Discount code: Gladden100 ($100 off the Zona Plus at www.zona.com)

Do you know the importance of breathing, listening, and being masterful? In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden talks with Jason Campbell, a 7th-degree black belt who has been teaching breath mastery for over three decades and is co-founder of Zen Wellness. He has composed over 100 albums and been #1 on multiple Billboard and Amazon charts. His combination of breath and music will take you on a journey of vibrant health, energy, and mental clarity. This episode discusses breath, energy, music, mental clarity, meditation, and mastery. Listen to find out about Jason's unique perspective on health, wellness, and spiritual growth. Dr. Gladden introduces Jason Campbell and talks about the life energy circle. (2:08) Jason discusses being helpful and happy and what emotional mastery means. (5:25) Dr. Gladden mentions that it's the energy and consciousness that transforms everything and how a raggedy shirt can be the most beautiful thing on the planet. (7:40) Jason explains that there are many Buddhas and what "Buddha" means. (9:05) Jason talks about the voice in the head being neither good nor bad and how it is the first level of meditation. (11:05) Jason reminds us that the closest number to infinity is zero, which is a good way to conceptualize how you can go to the place of everything by going to the place of nothing. (13:30) When you go to the place of silence; you have access to everything. Jason tells us how. (14:20) Dr. Gladden asks Jason if he has traveled or lived somewhere else in the process of gaining all this knowledge and spiritual growth. (16:15) Jason speaks about the difficulty of thinking your way into happiness. (18:02) Dr. Gladden's elaborates on the practice of framing our experiences and feelings in such a way that allows us to keep our center and/or heal, then asks Jason about a time in his life when he remembers not having the ability to do that yet. (20:42) Jason mentions that the ear picks up anywhere between like 20 Hertz and 20,000 Hertz. (22:06) Jason explains breath, movement, and tension. (24:13) Jason guides the listeners through breathing examples. (26:57) Dr. Gladden and Jason discuss Jason buying a town and what are his plans with it. (30:26) Dr. Gladden questions Jason about the challenges he is currently facing. (33:10) Dr. Gladden says that one of the essential things we can develop is a sense of adaptability. (35:03) Jason talks about the importance of being able to recover quickly when you are pulled off center. (37:17) Dr. Gladden questions Jason about how his music is used and what the intentions are. (41:00) Jason speaks about the type of music he makes and how he can make music for different purposes. (43:15) Jason tells us about his dog called Serenity and how she reacted to the music he makes. (46:13) Dr. Gladden mentions the importance of being centered and how he has personally benefited from it. (49:30) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To check out Jason Campbell's work: www.zenpiano.com Zenwellness.us Geniusx.com

Join Dr. Jeffrey Gladden in this wonderful conversation with Doni Wilson, a leading expert in hormones and epigenetics. Dr. Doni is a naturopathic doctor, certified professional midwife, and certified nutrition specialist with over two decades of experience helping patients reverse challenging health conditions like fatigue, anxiety, autoimmunity, fertility, MTHFR, and HPV. In the process of solving her migraines, Dr. Doni developed her signature, proven Stress Recovery Protocol™, which identifies how stress uniquely affects each individual and then uses epigenetics to reoptimize health. This episode talks about stress, anxiety, depression, and their impact on health. They also talk about how stress is mastered instead of managed, how to reset your health, and the kind of healing that is truly foundational to crack the code on longevity. Show notes: Dr. Gladden welcomes Doni Wilson, and Doni talks about how she got into what she does. (1:44) Doni tells us how she researched how stress affects women during pregnancy and labor. (3:43) Doni explains how adrenaline and cortisol actually assist the body to function optimally. (5:20) Dr. Gladden elaborates on the types of stress that can stimulate longevity. (7:21) Dr. Gladden brings up the relationship between stress and not feeling safe. (9:40) Doni notes that if cortisol or adrenaline are imbalanced, stress cannot be mastered. (12:38) Doni tells us what we need to know about our bodies, to be able to provide the proper treatment for ourselves. (14:16) Doni talks about the benefits of testing cortisol at different times throughout the day. (16:56) Doni introduces us to the patterns she developed called "the stress types". (18:55) Doni recounts how she helped her adrenal glands recover and find optimal levels, and tells us what things we can do daily to help us optimize ours. (21:30) Dr. Gladden asks about heart rate variability and describes it as another window to stress. (24:05) Doni notes how heart rate variability information helps us make the right decisions. (27:55) Doni goes through how she uses food sensitivity panels. (30:25) Dr. Gladden explains how stress in mothers could affect children's life expectancy. (33:20) Doni talks about the Incas and their three-level approach to full health and balance as individuals who are also a part of something bigger. (35:50) Dr. Gladden speaks about how people with spiritual connections and beliefs heal faster. (39:26) Doni brings up the power that psychedelics have to give us a birds-eye-view of our lives and a fresh perspective. (43:20) Doni cites how she explores different possibilities in her book. (46:29) Doni gives her takeaways for listeners who want to optimize their longevity. (51:22) Dr. Gladden elaborates on how giving yourself love and safety, will actually spread out to other people and drip down your generational lineage to expand that healing everywhere. (54:00) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To reach out to Dr. Doni and/or learn more about her and her incredible work/book: https://doctordoni.com/ IG: @drdoniwilson TW: @glutenfreedoc FB: Dr. Doni Wilson, ND YT: Dr. Doni Wilson And to take her stress type quiz, go here: https://doctordoni.com/quiz/stress-quiz/

Join Dr. Jeffrey Gladden in this chat with Gary Richter, one of the top ten veterinarians in the United States for 2012, and America's Favorite Veterinarian in 2015 by the American Veterinary Medical Foundation (AVMF). Gary is a graduate of the University of Florida with a B.S. in animal science, an M.S. in veterinary medical science, and a doctorate of veterinary medicine with honors. He launched Holistic Veterinary Care in 2009 (in Oakland, California), is certified in veterinary acupuncture and veterinary chiropractic, and uses these therapies along with his veterinary medical education to achieve better outcomes for his patients. In this episode, they talk about how pet owners can use longevity science and practices to extend the lifespan and healthspan of their pets, the things you can easily do at home that will make a huge difference in your pet's health immediately and in the long run, and which traditional practices to stay away from. If you're going to live longer, you'll want your pet to do that with you. Show notes: 00:55 Dr. Gladden introduces the episode's guest and topic. 02:14 Dr. Gladden asks what are some of the things people can do that have an impact on the health and longevity of their pets. 02:38 Gary explains why this is not only an animal health and welfare issue but also a human health issue. 03:37 Dr. Gladden brings up the Life Energy circle in our Mosaic of Ages and the role that pets could play in that. They proceed to elaborate on the unconditional element of this kind of connection and the profound effects it can have in a person's well-being. 06:27 What are some of the things people are doing wrong, though well-intended? 06:50 Gary tells us what is the single biggest thing we can do to help our pet live a better life. 07:34 Gary explains what's wrong with regular dry and canned food for pets. 08:27 Gary recalls what he was taught in school about pet nutrition, which is part of the problem. 08:50 So, what is the solution? Gary introduces "biologically appropriate food". 10:04 Dr. Gladden asks for clarification on what a "whole food diet" looks like for pets. 12:13 Gary classifies dogs and cats in appropriate carnivore-omnivore categories. 13:12 Gary clarifies what dogs actually need in their food and what's not necessary. 14:05 Dr. Gladden raises the question of variety in our pet's diet. 14:56 Gary mentions the two things to keep in mind to work on a balanced diet for our pets. 15:41 How do we figure out if we're giving them a balanced diet? Gary give us guidance. 16:59 Where do we get this kind of food? And how do we choose between our options? 18:41 Gary lists out some nationally available brands. 19:54 Dr. Gladden talks about food acting as medicine or poison both for pets and people. 20:06 Dr. Gladden and Gary go into the costs of feeding our pets with regular dry or canned food vs whole foods. 21:41 Dr. Gladden asks Gary if dogs should NEVER eat regular dry or canned food. 22:36 Gary explains the greatest advantage that pets have over humans in terms of keeping a healthy balanced diet. This is the power that we have. 23:10 Dr. Gladden elaborates on the power of constructing the environment to support the mission. 24:50 Gary talks about table scraps and things we definitely want to keep away from our dogs. 26:35 Gary explains why chocolate is more problematic now than it was a while ago. 27:46 Dairy in our pets' diet is discussed. 28:50 What happens when you get a dog or a cat off kibble and onto a fresh food diet? 29:56 Dr. Gladden asks if giving pets nutrient-dense food has the same effects, in terms of satiation, weight loss, etc., as it does in humans. 30:26 Gary clarifies what "meat for dogs" extends to and the level of nutrition there. 31:47 Gary and Dr. Gladden discuss tripe: what it is and the ways you can feed it to your dog. Do they like it? 33:00 Dr. Gladden brings up the aging process in animals and asks Gary to elaborate. Is the seven years per one human year thing true? 34:30 Gary tells us what is the real key to promoting longevity in our pets. 35:32 Not all exercise will be of benefit to our dogs in the long run. Gary explains why. 37:51 Is there a way to rehab our dogs from those activities that give them joy but might be detrimental to their health? Dr. Gladden asks. 39:23 Gary and Dr. Gladden discuss the idea of maybe putting together a cocktail of peptides to help our very active pets heal and regenerate, as well as working dogs. 41:39 Gary and Dr. Gladden talk about figuring out how to give our dogs hydrogen water or something similar to help them recover, and the possibility of future projects together. 43:43 Dr. Gladden explains what he's measuring in humans right now, the breakthroughs that he's having and talks about maybe setting up that kind of trial for animals. 44:37 Dr. Gladden asks Gary how we can help prevent age-related diseases in our pets. 45:42 Gary talks about different kinds of diseases and the different kinds of dogs that tend to develop them. 46:55 Gary brings up research showing a relationship between certain types of cancer and spaying/neutering. Him and Dr. Gladden elaborate on the possible effects of spaying/neutering in pets' health in the long run. 49:52 There is a physiologic difference in dogs that were spayed/neutered at a younger age. 50:57 What is routinely recommended in veterinary medicine that might or might not be good for your pet? 53:00 Gary talks vaccines and the practice of over vaccinating our pets. 54:34 How to avoid over vaccination. Gary explains his method. 56:17 Gary explains the danger with parvo. 57:18 Dr. Gladden asks for Gary's expert take on the vaccination topic in regards to cats. 59:01 Dr. Gladden asks about the kinds of diseases or infections that our pets could transmit to us. What could we be exposed to? 1:01:36 Gary gives out the different websites people can go to to get educated, connect with him, get nutritious food for their pets, and even scope out the new pet wearables he's coming out with. For more information on our mission & approach to longevity, health & human performance optimization, how to become a client, or more details regarding this and other podcast episodes, visit our website: www.gladdenlongevity.com Follow us on social media! Instagram: @gladdenlongevity Twitter: @gladdenlongevit Facebook: @GladdenLongevity And for more information on Dr. Gary Richter, his practice, his ultimate pet health guide on nutrition, and pet wearables, visit his websites and social media pages! https://drgaryrichter.com/ www.PetVetExpert.com www.HolisticVetCare.com www.MyPetThrives.com www.UltimatePetNutrition.com www.PetMetrics.com IG: @petvetexpert / @holisticvetcare / @ultimatepetnutrition TW: @petvetexpert / @ultpetnutrition FB: Dr. Gary Richter YT: Ultimate Pet Nutrition

Join Dr. Gladden and Ian Mitchell on this conversation about Carbon60 and the wonders it can do in terms of optimizing your body's internal performance and overall health. Ian is an inventor, a biochemist, a pharmaceutical developer, and specializes in anti-aging. A research scientist who studied Chemistry (ACS Track) at Mississippi State University and Jazz Performance at the University of New Orleans, working with the type of people who want to experience superhuman performance, he has 25 years of experience making contributions across multiple fields. Over the past decade he has developed multiple novel therapeutics using Lipofullerenic-Conjugates and holds multiple patents in the field of nano-medicine. Additionally, he developed multiple products focused on the convergence of mobile telecommunications and biomedical engineering, as well as nanofluidic multi-assay systems for use with Lab-on-Chip (LoC) devices, and holds joint patents with the University of Tulsa for viral inhibitors. He was a lead fabrication consultant for NASA's "ENDURANCE mission" project to Europa. Currently, he is the lead scientist at Biocharged and Wizard Sciences, Polymath in Residence at Ecliptic Capital, and head of R&D for Biochacked. Ian has managed to not only enhance energy production in the body but also increase its capacity from a sub-cellular level with Carbon60, as well as help it fight infection in the deepest way possible with a cocktail including this molecule that you will want to find out about. Show notes: 00:55 Dr. Gladden gives a description of the episode's subject matter. 01:47 Dr. Gladden introduces Ian Mitchell and Carbon60. 02:42 Ian tells his personal story and journey towards his current endeavor with Carbon60. 05:21 Dr. Gladden interjects and explains what "p53 knockout" is for the audience. 05:56 Ian describes exactly what he did when testing the Carbon60 in vivo and the impressive results obtained, consequently, what he kept learning about the Carbon60 molecule. 07:06 Ian explains what Carbon60 can do inside the body. 07:43 Dr. Gladden explains exactly what this means in terms of function, how Carbon60 is counteracting the body's decline. 09:33 Ian describes how he started to study the body's process to create ATP (energy) in order to positively optimize it in every way without negatively interfering in any particular area. 10:15 This is how we get our 400hp motor back. 10:51 How do we replace the damaged parts that are not going to fix themselves? 10:57 Dr. Gladden gives a summary of what Ian is doing with Carbon60 in 3 parts. How it is optimizing mitochondrial function, what it is adding to the machinery, and how it is restoring the parts. 12:01 Ian shares his personal story with infection and describes how it affected his function greatly. 13:18 Ian tells what he had to do to get the correct diagnosis as to what was going on with him on a sub-cellular level to be able to heal himself. 14:31 Dr. Gladden asks if what he discovered is what people experiencing long term effects of infection around the globe right now might be suffering from after they stop showing signs of infection on a surface level. 15:10 Ian talks about the unexpected use of Benadryl to counteract this sub-cellular issue, coupled with Carbon60 and Urolithin A for full recovery assisted by mitophagy. 16:22 Dr. Gladden explains what the cell does during autophagy and mitophagy. 16:51 Ian explains how the body fights a virus and how he helped the body do this all the way to the sub-cellular level to truly heal. 18:23 Dr. Gladden asks if Ian has been adding Urolithin A to his products, and Ian describes what he has discovered by using himself as a guinea pig. 19:26 Ian talks about what he has done with the p53 knockout experiment to feel confident that there is some mechanism in his product that is suppressing oncological formations. 21:01 Dr. Gladden asks Ian what he thinks about the vaccine effects on mitochondria. 23:02 Ian talks about looking into very small embryonic-like stem cells, adding those to the procedure in his lab, and the resulting effects of it. How he got his capacity back. 23:55 Dr. Gladden takes the products that Ian has been using and groups them together in a trilogy. Ian further explains what the Benadryl's role is within the cocktail. 25:42 Dr. Gladden and Ian introduce the product that Ian has been working on that is stopping tumor cells from dividing. Ian explains how he has optimized it and what universities in Spain and USA have discovered in regards to cancer. This is how cancer cells work and what Ian is doing to interfere in their process. 31:16 Dr. Gladden asks if Ian is using a cocktail of things to do this or what things is he linking together as a strategy. 32:00 Ian goes on to list and explain the strategy and its elements. 33:21 Deterium-depleted water is introduced, which is another way of mitochondrial modulation. It's like higher octane fuel, Ryan explains. 35:45 Is there a way to take ordinary water and turn it into Deterium-depleted water? Dr. Gladden asks. 37:27 Ian tells us about the method he developed to produce Deterium-depleted water at a much more attainable price, solving the major current issue with it. 40:00 Dr. Gladden brings up the brain and Ian's NeuralRx product. Ian tells what this product was actually designed for, and Dr. Gladden talks about what they have found out in using it. 43:26 Ian explains exactly what NeuralRx does in the brain. 43:39 Dr. G interrupts to explain what the glymphatic system is to the audience and what it does. 45:40 What happens after a few weeks using NeuralRx? 46:44 What can you do to increase NeuralRx's capacity? 47:36 Dr. Gladden lists the benefits and capacities of Ian's products. 48:00 Ian describes what he has been accomplishing in preliminary testing with one of his experimental compounds. 48:36 Dr. Gladden tells the audience where they can find Ian's products and asks what is coming to market next. 49:44 Ian explains what he is trying to address exactly in terms of longevity. 51:26 Dr. Gladden asks Ian really how recovered he feels in his journey. 52:25 Dr. Gladden clarifies the kind of strategy they're going after to get the body all the way back to optimal health. 53:15 They say goodbye. For more information on our mission & approach to longevity, health & human performance optimization, how to become a client, or more details regarding this and other podcast episodes, visit our website: www.gladdenlongevity.com Follow us on social media! Instagram: @gladdenlongevity Twitter: @gladdenlongevit Facebook: @GladdenLongevity For Ian Mitchell's products, visit the Wizard Sciences' website: www.wizardsciences.com Instagram: @wizardsciences "As close as you'll feel to limitless"

Join Dr. Gladden on this conversation with Ryan Smith about epigenetic age testing and DNA methylation. Ryan has a biochemistry degree from the University of Transylvania. He went to medical school and started clinical rotations before realizing he didn't want to be a doctor. That's when he pivoted to the world of pharmacy, focusing on peptide synthesis, and opened up Tailor Made Compounding. Ryan has been very successful in his endeavors, with Tailor Made Compounding becoming the 4th fastest growing healthcare company at the time, investing in several other functional medicine spaces and, eventually, starting TruDiagnostic. This is a CLIA certified lab and health data company focused and committed to research with over 30 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. They have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested and continue to lead the space in epigenetic methylation interpretation and diagnostic prediction. In this episode, him and Dr. Gladden discuss how epigenetic age testing and DNA methylation have evolved, the different kinds of clocks that exist now and what they measure, as well as the advances being made and envisioned in the disease prevention and age reversal spaces. Show notes: 00:55 Dr. Gladden gives a description of this episode and an introduction of Ryan Smith. 02:20 Dr. Gladden explains why he is excited for this show. 03:15 Ryan introduces the audience to TruAge and tells us the big takeaway from this testing. 04:50 What is epigenetic methylation? What are the two main epigenetic marks? Ryan explains our DNA's "on and off switches". 05:57 Dr. Gladden clarifies what is being measured exactly. 06:29 The concept of methylation clock is introduced by Dr. Gladden, and he explains how it keeps track of the aging process but also contributes to it. 07:11 Dr. Gladden asks if Ryan's company is measuring acetylation patterns as well. 07:17 Ryan talks about clinical trials where they are also measuring acetylation patterns and why it's proven not to be ready for prime time large-scale investigation. 08:20 Dr. Gladden asks if they're hitting a plateau in terms of accuracy with the amount of genes being tested. 09:02 Ryan explains why doubling the amount of genes being tested doesn't necessarily translate into a doubling of accuracy. 09:09 How are they getting an insight into the path of physiology? Ryan talks about seeing what is changing and why it is changing, why this is the best way to capture the aging process (which is the biggest risk factor for chronic disease and death) and what questions they are trying to answer. 09:59 Dr. Gladden asks if they are hitting a plateau in cost-effectiveness. 10:49 Dr. Gladden tells the audience why they should care about this and what sets TruDiagnostic apart from other methylation companies. They can predict disease and mortality. 13:44 Ryan talks about the evolution of these algorithms and what people can expect from the reports of their testing. 14:40 Second and third generation clocks are introduced during this intervention before tackling their reports individually. 17:15 Dr. Gladden talks about the benefits gained from these reports/testing. 18:55 What can people do to impact their methylation? Ryan elaborates on the different types of interventions, from lifestyle changes to clinical interventions. 23:19 Dr. Gladden introduces very small embryonic-like stem cells and talks about how there's data being recorded in some trials where these are moving the epigenetic age even 3 or 4 years back in time. 25:30 Ryan talks about what he's seeing with plasma and plasmapheresis interventions. Explains why the results they're seeing are giving them so much hope that these therapies might be one of the ways to reverse the clock. 29:30 Dr. Gladden explains why they can't look at one data point and say that's the answer in this field. 29:58 They introduce the DunedinPace algorithm for rate of aging, which is the first ever third generation algorithm. Ryan explains why it's one of their favorites and how it is making things clearer and giving one of the best metrics they can offer. 35:00 Dr. Gladden talks about what they don't have dialed in yet with these therapies. 35:19 Ryan describes how they're trying to bridge the gap by providing answers to those "how long" questions with their data sets. 36:20 Will the system spring back to its natural age? Or will we be able to reset it? Dr. Gladden poses the question based on the concept of transient epigenetic aging. 36:58 Ryan talks about what he thinks is probably the most exciting area of age reversal right now. 38:49 Dr. Gladden asks Ryan how people can reasonably compare between companies doing this kind of testing and choose their best option. 40:40 Ryan explains the different tissues that can be used for testing and how that's going to affect the algorithm's results. 41:55 Ryan explains the importance of these algorithms' (clocks') precision. 43:20 Dr. Gladden talks about his experience with methylation ages in urine and how he uses it as a screening test. 44:53 Dr. Gladden introduces the GrimAge algorithm, which predicts when someone is going to die. 45:49 Ryan elaborates on the GrimAge algorithm's excellence and explains how it is the most accurate and most predictive. 49:43 Dr. Gladden explains what methylation measurements are actually doing and what they mean for the audience. 51:16 Dr. Gladden asks Ryan his top 3 pieces of advice to optimize your longevity, health and human performance. Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast https://twitter.com/TruDiagnostic https://www.instagram.com/trudiagnosticofficial/ https://www.youtube.com/channel/UC408EGTLhAf8haqe1H5Ep_Q https://www.facebook.com/TruDiagnostic/ https://www.linkedin.com/company/trudiagnostic/

Join Dr. Gladden and Tina Anderson on this conversation about spore-based probiotics and their ability to rehab your overall health by targeting the bacteria in your gut. Tina Anderson, formerly a lawyer, used to work in the pharmaceutical industry before finding out that it wasn't the best way for her to help people and change their lives. After a harsh revelation during the peak of their careers, Tina and her husband pivoted to the world of natural and progressive health, and disease prevention. As a result of their discovery, they created a unique supplement with superior probiotic strains, giving birth to Just Thrive. These spore-based practitioner grade probiotics are the product that Tina and her husband created to help you take control of your health and change your life. 01:10 Dr. Gladden tells us what's exciting about this episode and the things we will come to understand. 02:10 Dr. Gladden introduces Tina Anderson. 03:20 Tina shares her story: the journey to the world of probiotics. 04:15 We get an insight into the abuses in the pharmaceutical industry. 04:53 Tina tells us the Sales Representative anecdote that really made them pivot from the pharmaceutical industry in the midst of a high point in her and her husband's careers. 06:47 We learn about the day the opportunity to create Just Thrive presented itself for Tina and her husband. 08:16 Tina lets us in on her biggest motivation. 08:45 Tina explains why her husband was seeing a naturopath at that time. Was someone in the family experiencing gut issues? 09:59 We are introduced to spore-based probiotics and what's special about them. 10:48 Tina explains what is the biggest difference between spore-based probiotics and regular probiotics. 10:58 Dr. Gladden explains that dead bacteria can also have an effect on our guts but live bacteria could, theoretically, be better. 11:25 Tina elaborates on what spore probiotics do that other probiotics can't do. 12:08 Tina talks about a gut model study where they confirmed a 30% favorable shift in the microbiome after 2 weeks on it. 13:04 Dr. Gladden explains that there is no "normal" gut biome. 14:08 We find out how exactly are these spores modulating the gut biome. 14:25 Tina makes a very good analogy where our gut is a garden and sporebiotics are the gardener and not just new seeds, as a way to differentiate them and their effects from those of regular probiotics. Are new seeds enough? Or do we need a gardener? 15:15 Tina also clarifies a big distinction in the colonization period of spore-based probiotics vs non-spore probiotics. 15:41 Dr. Gladden explains the concept of spores and asks how they work in this context. 16:57 Tina talks about a study where they measured the spores antibiotic survival capabilities. 17:16 Dr. Gladden elaborates on how antibiotics alter the gut biome. 17:54 Tina explains that spore probiotics can rehab AND maintain our health. 19:05 Dr. Gladden asks if sporebiotics can repair leaky-gut. Tina goes on to describe just how impressive is the level of restoration spores can achieve, proved by a double-blinded study that was performed. 21:31 Tina gives a better understanding of how exponentially detrimental leaky-gut can be to our health with a helpful leaky faucet comparison. 22:03 Dr. Gladden explains that the body is not built to be fragile but it has a threshold, resulting in people living with issues they don't know they have which are driving their inflammation levels up and accelerating aging. 22:30 Tina lists a number of issues and disorders that are stemming from the gut, although we don't associate them with it. 24:05 Tina describes the spore-based probiotics success with bloating issues, diarrhea, and constipation. 24:40 Tina explains that our gut is foundational for our health and how it is the starting point of general wellness. 25:26 Dr.Gladden asks about using spore-based probiotics with antibiotics to decrease the negative effects of the latter, like induced diarrhea. Tina talks about a study that proved the spores effectiveness with this, and survivability to the strongest antibiotics. 26:31 How is it helping people's brain function? 27:00 Tina lists all the brain hormones that are produced in our gut. 27:17 Tina introduces the psychobiotic! 28:02 Tina tells us about other offenders of brain health that the psychobiotic is also helping with. 28:44 Dr. Gladden introduces the topic of probiotic cocktails. 29:17 Tina explains why a cocktail makes much more sense than just taking one probiotic. 30:27 Dr. Gladden inquires about what's on the drawing board for Just Thrive. 31:35 Tina explains that they're only focused on bringing what's truly missing in the market and how they want to make an impact by providing what's needed and what's best. 32:18 Dr. Gladden asks what kind of conditions/disorders they're targeting with the psychobiotic. 32:47 Tina explains how the psychobiotic targets not only certain disorders but specifically works to improve cognitive function too. 33:09 How quickly does this psychobiotic work? 34:04 Tina gives her recommendations for us to take action in favor of our longevity. 34:49 Dr. G explains how fasting acts as a workout for our gut biome. 35:09 Tina tells us the number of hours it would be beneficial to fast for and how to get there. 36:10 Tina shares which probiotics she takes right now. 36:44 Dr. Gladden talks about how he tries not to buy the same thing twice when he's doing his grocery shopping, and Tina explains how having a diverse microbiome is the key to being healthy. 39:04 Tina explains what is the key difference between their spore-based probiotics and all the other probiotics that are now coming into the market. 40:03 Dr. Gladden and Tina tell us how we can get a hold of the direct to consumer bio equivalent version of practitioner grade spore-based probiotics through Just Thrive. 41:13 Tina gives out the Just Thrive's website address: (justthrivehealth.com) to get these sporebiotics with a 20% discount. 41:55 Dr. Gladden and Tina Anderson say goodbye. Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! Learn more about the better approach to gut health & wellness on their website: justthrivehealth.com Or call the number: 1-800-455-8939 Email them at: info@justthrivehealth.com Look them up on social media: Instagram: justthrivehealth Facebook: justthrive Discount code: gladden15

Join Dr. Jeffrey Gladden in this conversation with Colleen Cutcliffe, Co-Founder and CEO of Pendulum Therapeutics. Colleen earned a PhD in Biochemistry and Microbiology from Johns Hopkins University, did her postdoctoral work at Northwestern University, and is on a mission to make millions healthier through microbiome-targeted medical probiotics. In this episode, they discuss her personal journey to the creation and development of Pendulum, how it works to treat conditions like metabolic syndrome, inflammation and neurodegeneration, and the ways in which treating and maintaining a healthy microbiome could be a hack to successful aging and disease-free longevity. If you are looking for a natural route to overall health and optimization, this episode is for you. Show notes: Dr. Gladden introduces Colleen, and she introduces herself, gives us her personal journey to the creation and development of Pendulum, her personal connection to it. (1:30) Colleen talks creating products that have the efficacy of a drug but the safety of a probiotic. (2:40) Colleen mentions a study that showed how kids taking antibiotics before six months of age are systematically more prone to diseases like obesity and type two diabetes as they age. Dr. Gladden mentions how antibiotics affect children. (4:00) Colleen tells us how butyrate is a small molecule with a really important role in a variety of different things. Our colon cells, for example, are the only cells in our entire body that use butyrate as their source of energy, as opposed to glucose. (6:10) Dr. Gladden explains how the fiber metabolism generates butyrate that feeds the intestinal lining, including how fascinating it is that this butyrate is responsible for releasing GLP-1. (7:30) Colleen clarifies that if you are missing your microbes, ingesting fiber does not make much difference. (10:00) Dr. Gladden mentions some misconceptions about microbiomes and comparing the person's stool against an "ideal" stool. (11:59) Dr. Gladden talks about keystone strains and explains that what we are eating affects and influences them, highlighting the importance of eating different kinds of fibers. (14:00) Colleen describes a study they did, seeing a way to influence the microbiome and then have this impact on A1C and blood glucose. (17:00) Dr. Gladden talks about how microbes also affect appetites and dictate your cravings. (19:00) Colleen explains that the (Pendulum) formulation is stable but needs to be refrigerated, and lists the five strains: Akkermansia muciniphila, Anaerobutyricum hallii, Bifidobacterium infantis, Clostridium butyricum, and Clostridium beijerinckii. (21:10) Colleen mentions some of the trials they have done and the approach they adopted. (24:10) Dr. Gladden brings up neuroinflammation and poses the question of Pendulum's capacity in decreasing it. (27:04) Colleen elaborates on the known relationship between managing your blood glucose spikes and neural inflammation. (28:05) Dr. Gladden explains what resting metabolic rate is and how it is measured. (32:44) Colleen talks about the importance and role of diversity in your diet to metabolize some foods, maintaining "the fence to your garden" (gut lining of your microbiome) and the regulation of mucin, which is the glue that keeps everything properly in place. (35:34) Colleen talks about what is on the drawing board for her at the moment. (39:15) Dr. Gladden brings up the connection between autism and microbiomes. (41:30) Colleen talks about considering microbiomes as an additional intervention effort. (43:25) Colleen gives out her three takeaways for listeners: the diversification of our microbiome, the importance of regulating how your body metabolizes sugar, and giving yourself a boost with the Pendulum glucose control strains paired with the proper diet. (45:39) Colleen emphasizes the importance of people consulting their physicians when making changes that could affect their health. (48:00) Visit our website, www.gladdenlongevitypodcast.com, for more information on this episode and other episodes as well. Follow us on social media! Instagram: @gladdenlongevitypodcast Twitter: @GLPodcast_ Facebook: @GladdenLongevityPodcast To learn more about Gladden Longevity and how you can become a client, visit www.gladdenlongevity.com today! Website: Learn more about the next generation of gut health by visiting www.pendulumlife.com Instagram: @pendulumlifeco TikTok: pendulumlife Facebook: https://www.facebook.com/PendulumLife/ (For Gladden Longevity listeners, use code GL20 to subscribe and save 20% on your first month of Pendulum's subscription products.)